Aminomethylene Peptide Nucleic Acid (am-PNA): Synthesis, Regio-/Stereospecific DNA Binding, And Differential Cell Uptake of (α/γ,R/S)am-PNA Analogues

2012 ◽  
Vol 77 (13) ◽  
pp. 5696-5704 ◽  
Author(s):  
Roopa Mitra ◽  
Krishna N. Ganesh
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Cell Uptake ◽  
Pna Synthesis ◽  
Differential Cell

DNA Binding and Cleavage by a Cationic Manganese Porphyrin−Peptide Nucleic Acid Conjugate

1997 ◽  
Vol 8 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Pascal Bigey ◽  
Søren Holst Sönnichsen ◽  
Bernard Meunier ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Manganese Porphyrin ◽  
Acid Conjugate ◽  
Dna Binding And Cleavage

Synthesis and DNA Binding Property of a Novel Peptide Nucleic Acid that Containscis-4-Adeninyl-L-prolinol Unit

2001 ◽  
Vol 30 (7) ◽  
pp. 634-635 ◽  
Author(s):  
Masanori Shigeyasu ◽  
Masayasu Kuwahara ◽  
Masahiko Sisido ◽  
Teruhiko Ishikawa
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Binding Property ◽  
Dna Binding Property

Synthesis of α-(R)-/γ-(S)-Dimethyl Substituted Peptide Nucleic Acid Submonomer Using Mitsunobu Reaction

2019 ◽  
Vol 16 (5) ◽  
pp. 437-446
Author(s):  
Ahmed S. Abdelbaky ◽  
Ivan A. Prokhorov ◽  
Igor P. Smirnov ◽  
Kristina M. Koroleva ◽  
Vitaliy I. Shvets ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Solid Phase ◽  
Genetic Diseases ◽  
Mitsunobu Reaction ◽  
Phase Synthesis ◽  
Dna And Rna ◽  
Pna Synthesis ◽  
Biomedical Technologies

One of the major challenges facing modern biochemical and biomedical technologies are finding molecular tools for diagnosis and detection of genetic diseases. In this connection, several classes of oligonucleotides have been developed that can recognize and bind to DNA and RNA with high affinity and sequence selectivity and withstand enzymatic degradation by proteases and nucleases; however, few can traverse the cell membrane on their own. One such promising class of nucleic acid mimics developed in the last two decades which showed good results in vitro, are the peptide nucleic acids (PNAs). New chiral α- and γ-peptide Nucleic Acid (PNA) submonomer with methyl substituents in pseudopeptide backbone were synthesized via Mitsunobu reaction. The α-(R)-/γ-(S)-configuration of the chiral centres will ensure the preorganization of the PNA oligomer into a right-handed helix. The results obtained showed that Boc/Fmoc-submonomer compatible with Boc-protocol PNAs solid-phase synthesis on an MBHA resin. We synthesized simple and efficient α-R-, γ-S-disubstituted PNA submonomer based on L-Ala and D-Ala with the construction of the intermediate pseudopeptide moiety by Mitsunobu reaction for subsequent use in the Boc-Protocol of solid phase PNA synthesis.

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

2003 ◽  
Vol 5 (23) ◽  
pp. 4445-4447 ◽  
Author(s):  
François Debaene ◽  
Nicolas Winssinger
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Solid Phase ◽  
Alternative Strategy ◽  
Pna Synthesis

Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

2003 ◽  
pp. 1102-1103 ◽  
Author(s):  
Stefano Sforza ◽  
Tullia Tedeschi ◽  
Roberto Corradini ◽  
Arnaldo Dossena ◽  
Rosangela Marchelli
Keyword(s):  
Mass Spectrometry ◽  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Electrospray Mass Spectrometry ◽  
Direction Control

Transition Metal Derivatives of Peptide Nucleic Acid (PNA) OligomersSynthesis, Characterization, and DNA Binding

2000 ◽  
Vol 11 (6) ◽  
pp. 741-743 ◽  
Author(s):  
Jeroen C. Verheijen ◽  
Gijs A. van der Marel ◽  
Jacques H. van Boom ◽  
Nils Metzler-Nolte
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Transition Metal ◽  
Peptide Nucleic Acid ◽  
Metal Derivatives ◽  
Derivatives Of

Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against theMYCN oncogene

Chirality ◽  
2008 ◽  
Vol 20 (3-4) ◽  
pp. 494-500 ◽  
Author(s):  
Andrea Faccini ◽  
Andrea Tortori ◽  
Tullia Tedeschi ◽  
Stefano Sforza ◽  
Roberto Tonelli ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Anticancer Peptide ◽  
Circular Dichroïsm

The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family

2016 ◽  
Vol 30 (5) ◽  
pp. e2600 ◽  
Author(s):  
Grzegorz Machnik ◽  
Łukasz Bułdak ◽  
Jarosław Ruczyński ◽  
Tomasz Gąsior ◽  
Małgorzata Huzarska ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Single Stranded Dna ◽  
Strand Invasion ◽  
Specific Sequences

ChemInform Abstract: Synthesis and DNA Binding Property of a Novel Peptide Nucleic Acid that Contains cis-4-Adeninyl-L-prolinol Unit.

ChemInform ◽  
2010 ◽  
Vol 32 (51) ◽  
pp. no-no
Author(s):  
Masanori Shigeyasu ◽  
Masayasu Kuwahara ◽  
Masahiko Sisido ◽  
Teruhiko Ishikawa
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Binding Property ◽  
Dna Binding Property

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

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