Chemical and Biological Characterization of Technetium(I) and Rhenium(I) Tricarbonyl Complexes with Dithioether Ligands Serving as Linkers for Coupling the Tc(CO)3and Re(CO)3Moieties to Biologically Active Molecules

2000 ◽  
Vol 11 (3) ◽  
pp. 414-424 ◽  
Author(s):  
H.-J. Pietzsch ◽  
A. Gupta ◽  
M. Reisgys ◽  
A. Drews ◽  
S. Seifert ◽  
...  
Keyword(s):  
Biologically Active ◽  
Biological Characterization

scholarly journals Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 667 ◽  
Author(s):  
Carolina Proaño-Bolaños ◽  
Ailín Blasco-Zúñiga ◽  
José Rafael Almeida ◽  
Lei Wang ◽  
Miguel Angel Llumiquinga ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Structural Diversity ◽  
Biologically Active ◽  
Biological Characterization ◽  
Skin Secretion ◽  
Peptide Profile ◽  
Active Chemical ◽  
Molecular Masses ◽  
Skin Secretions

Frog skin secretions contain medically-valuable molecules, which are useful for the discovery of new biopharmaceuticals. The peptide profile of the skin secretion of Agalychnis spurrelli has not been investigated; therefore, the structural and biological characterization of its compounds signify an inestimable opportunity to acquire new biologically-active chemical scaffolds. In this work, skin secretion from this amphibian was analysed by molecular cloning and tandem mass spectrometry. Although the extent of this work was not exhaustive, eleven skin secretion peptides belonging to five peptide families were identified. Among these, we report the occurrence of two phyllokinins, and one medusin-SP which were previously reported in other related species. In addition, eight novel peptides were identified, including four dermaseptins, DRS-SP2 to DRS-SP5, one phylloseptin-SP1, and three orphan peptides. Phylloseptin-SP1 and dermaseptins-SP2 were identified in HPLC fractions based on their molecular masses determined by MALDI-TOF MS. Among the antimicrobial peptides, dermaseptin-SP2 was the most potent, inhibiting Escherichia coli, Staphylococcus aureus, and ORSA with a minimum inhibitory concentration (MIC) of 2.68 μM, and Candida albicans with an MIC of 10.71 μM, without haemolytic effects. The peptides described in this study represent but a superficial glance at the considerable structural diversity of bioactive peptides produced in the skin secretion of A. spurrelli.

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

2005 ◽  
Vol 48 (16) ◽  
pp. 5373-5377 ◽  
Author(s):  
Rainer Albert ◽  
Klaus Hinterding ◽  
Volker Brinkmann ◽  
Danilo Guerini ◽  
Constanze Müller-Hartwieg ◽  
...  
Keyword(s):  
Active Species ◽  
Biologically Active ◽  
Biological Characterization ◽  
Single Stereoisomer

Characterization of photosystem II with the atomic-force microscope

1992 ◽  
Vol 50 (2) ◽  
pp. 1146-1147
Author(s):  
Kathleen M. Marr ◽  
Mary K. Lyon
Keyword(s):  
Photosystem Ii ◽  
Atomic Force Microscope ◽  
Three Dimensional ◽  
Biologically Active ◽  
Atomic Force ◽  
Freeze Etching ◽  
Image Averaging ◽  
Oxygen Evolving ◽  
Averaging Techniques

Photosystem II (PSII) is different from all other reaction centers in that it splits water to evolve oxygen and hydrogen ions. This unique ability to evolve oxygen is partly due to three oxygen evolving polypeptides (OEPs) associated with the PSII complex. Freeze etching on grana derived insideout membranes revealed that the OEPs contribute to the observed tetrameric nature of the PSIl particle; when the OEPs are removed, a distinct dimer emerges. Thus, the surface of the PSII complex changes dramatically upon removal of these polypeptides. The atomic force microscope (AFM) is ideal for examining surface topography. The instrument provides a topographical view of individual PSII complexes, giving relatively high resolution three-dimensional information without image averaging techniques. In addition, the use of a fluid cell allows a biologically active sample to be maintained under fully hydrated and physiologically buffered conditions. The OEPs associated with PSII may be sequentially removed, thereby changing the surface of the complex by one polypeptide at a time.

Phytoequivalence in the global marketplace for botanical products: chemical and biological characterization of Equisetum arvense extracts from America, Asia, and Europe

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Lee ◽  
MC Carles ◽  
J Hennell ◽  
C Khoo ◽  
S Govindaraghavan ◽  
...  
Keyword(s):  
Equisetum Arvense ◽  
Biological Characterization ◽  
Global Marketplace ◽  
Botanical Products

Characterization of Biologically Active Substances from Calendula officinalis

2018 ◽  
Vol 18 (14) ◽  
pp. 1167-1174 ◽  
Author(s):  
Petra Lovecka ◽  
Jan Lipov ◽  
Kamila Thumova ◽  
Anna Macurkova
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Calendula Officinalis ◽  
Active Substances

Identification, molecular and biological characterization of two novel secovirids in wild grass species in Belgium

2021 ◽  
Vol 298 ◽  
pp. 198397
Author(s):  
François J. Maclot ◽  
Virginie Debue ◽  
Arnaud G. Blouin ◽  
Núria Fontdevila Pareta ◽  
Lucie Tamisier ◽  
...  
Keyword(s):  
Grass Species ◽  
Biological Characterization ◽  
Wild Grass
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