Multidentate Block Copolymer Stabilization: A Versatile Strategy for Colloidal Superparamagnetic Iron Oxide Nanoparticles Exhibiting Excellent Colloidal Stability and Enhanced Positive MRI Visualization

2018 ◽  
pp. 107-128
Author(s):  
Nicky Chan ◽  
Puzhen Li ◽  
Wangchuan Xiao ◽  
Depannita Biswas ◽  
Philippe Legros ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Block Copolymer ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Enhanced encapsulation of superparamagnetic Fe3O4 in acidic core-containing micelles for magnetic resonance imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (130) ◽  
pp. 107938-107948 ◽  
Author(s):  
Depannita Biswas ◽  
Puzhen Li ◽  
Dapeng Liu ◽  
Jung Kwon Oh
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Block Copolymer ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Loading Level

Block copolymer-based magnetic nanoassembled structures with acidic cores exhibiting enhanced loading level of superparamagnetic iron oxide nanoparticles, thus having great potential for theranostics based on MRI.

Glyco-copolypeptide grafted magnetic nanoparticles: the interplay between particle dispersion and RNA loading

2016 ◽  
Vol 7 (19) ◽  
pp. 3221-3224 ◽  
Author(s):  
T. Borase ◽  
E. K. Fox ◽  
Fadwa El Haddassi ◽  
S.-A. Cryan ◽  
D. F. Brougham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Block Copolymer ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Particle Dispersion ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Lysine-glyco-copolypeptide grafted superparamagnetic iron oxide nanoparticles were prepared through N-carboxyanhydride (NCA) copolymerization. Statistical and block copolymer arrangements were obtained while keeping the overal composition constant.

scholarly journals Polyelectrolyte coating on superparamagnetic iron oxide nanoparticles as interface between magnetic core and biorelevant media

2016 ◽  
Vol 6 (6) ◽  
pp. 20160068 ◽  
Author(s):  
Etelka Tombácz ◽  
Katalin Farkas ◽  
Imre Földesi ◽  
Márta Szekeres ◽  
Erzsébet Illés ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
High Surface ◽  
Fatal Outcome ◽  
Superparamagnetic Iron Oxide ◽  
Surface Reactivity ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biorelevant Media

Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to fulfil the expectation of medicine regulatory agencies and ultimately that of biocompatibility. In this work, we show the high surface reactivity of naked SPIONs due to ≡Fe–OH sites, which can react with H + /OH − to form pH- and ionic strength-dependent charges. We explain the post-coating of naked SPIONs with organic polyacids via multi-site complex bonds formed spontaneously. The excess polyacids can be removed from the medium. The free COOH groups in coating are prone to react with active biomolecules like proteins. Charging and pH- and salt-dependent behaviour of carboxylated SPIONs were characterized quantitatively. The interrelation between the coating quality and colloidal stability measured under biorelevant conditions is discussed. Our coagulation kinetics results allow us to predict colloidal stability both on storage and in use; however, a simpler method would be required to test SPION preparations. Haemocompatibility tests (smears) support our qualification for good and bad SPION manufacturing; the latter ‘promises’ fatal outcome in vivo .

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