Synthesis of in Situ Cross-Linkable Macroporous Biodegradable Poly(propylene fumarate-co-ethylene glycol) Hydrogels

2002 ◽  
Vol 3 (2) ◽  
pp. 374-381 ◽  
Author(s):  
Esfandiar Behravesh ◽  
Seongbong Jo ◽  
Kyriacos Zygourakis ◽  
Antonios G. Mikos
Keyword(s):  
Ethylene Glycol ◽  
Biodegradable Poly ◽  
Poly Propylene

Biodegradable poly(propylene) carbonate using in-situ generated CuNPs coated Tamarindus indica filler for biomedical applications

2019 ◽  
Vol 19 ◽  
pp. 106-113 ◽  
Author(s):  
M.P. Indira Devi ◽  
N. Nallamuthu ◽  
N. Rajini ◽  
T. Senthil Muthu Kumar ◽  
Suchart Siengchin ◽  
...  
Keyword(s):  
Propylene Carbonate ◽  
Biomedical Applications ◽  
Tamarindus Indica ◽  
Biodegradable Poly ◽  
Poly Propylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

In situ time-resolved DXAFS study of Rh nanoparticle formation mechanism in ethylene glycol at elevated temperature

2012 ◽  
Vol 14 (9) ◽  
pp. 2983 ◽  
Author(s):  
Hiroyuki Asakura ◽  
Kentaro Teramura ◽  
Tetsuya Shishido ◽  
Tsunehiro Tanaka ◽  
Ning Yan ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Ethylene Glycol ◽  
Formation Mechanism ◽  
Time Resolved ◽  
Nanoparticle Formation

Characterization and Crystallization Kinetics of in situ Prepared Poly(propylene terephthalate)/SiO2 Nanocomposites

2009 ◽  
Vol 211 (1) ◽  
pp. 66-79 ◽  
Author(s):  
Dimitris S. Achilias ◽  
Dimitrios N. Bikiaris ◽  
Efthimios Papastergiadis ◽  
Dimitris Giliopoulos ◽  
George Z. Papageorgiou
Keyword(s):  
Crystallization Kinetics ◽  
Sio2 Nanocomposites ◽  
Poly Propylene ◽  
Kinetics Of
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