Magnetic Block Ionomer Complexes for Potential Dual Imaging and Therapeutic Agents

2012 ◽  
Vol 24 (11) ◽  
pp. 2056-2063 ◽  
Author(s):  
Nikorn Pothayee ◽  
Nipon Pothayee ◽  
Neeta Jain ◽  
Nan Hu ◽  
Sharavanan Balasubramaniam ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Block Ionomer Complexes ◽  
Dual Imaging ◽  
Block Ionomer

The main strategies for tuning BODIPY fluorophores into photosensitizers

2020 ◽  
Vol 24 (05n07) ◽  
pp. 603-635 ◽  
Author(s):  
Jun Wang ◽  
Qingbao Gong ◽  
Long Wang ◽  
Erhong Hao ◽  
Lijuan Jiao
Keyword(s):  
Singlet Oxygen ◽  
Fluorescent Dyes ◽  
Malignant Tumors ◽  
Therapeutic Agents ◽  
Invasive Technique ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Cancer Tumor ◽  
Dual Imaging

Photodynamic therapy (PDT) is a minimally invasive technique for the treatment of target malignant tumors via the generation of highly reactive singlet oxygen species. PDT treatment of cancer/tumor tissues greatly relies on the development of suitable stable, highly specific and efficient photosensitizers. BODIPY (Boron dipyrromethene) derivatives, as a class of well-developed, versatile fluorescent dyes, has emerged as a new class of PDT agents over the past decade. Many elegant strategies have been developed to enhance the singlet oxygen generation efficiency and the cancer/tumor cell selectivity of BODIPY-based photosensitizers to improve the therapeutic outcomes as well as to minimize the side effects. Many of the currently reported BODIPY-based photosensitizers are valuable dual imaging and therapeutic agents, which can efficiently generate singlet oxygen for PDT and emit fluorescence for in vivo imaging. Although the currently approved PDT agents used for clinical trials do not feature BODIPYs, this situation is expected to change. In this review, we provide an overview of the various strategies that have been used to improve the singlet oxygen generation efficiency for tuning BODIPY fluorophores into photosensitizers and dual imaging/therapeutic agents. Their photophysical properties and photocytotoxic activity including the absorption/emission wavelengths, the singlet oxygen generation efficiency ([Formula: see text] and the half maximal inhibitory concentration [Formula: see text] of these currently reported photosensitizers are summarized. We believe these newly developed BODIPY-based photosensitizers will broaden current concepts of strategies for PDT agent design, and promise to make an important contribution to the diagnosis and therapeutics for the treatment of cancer.

Cross-linked Polymeric Micelles based on Block Ionomer Complexes

2013 ◽  
Vol 23 (4) ◽  
pp. 179-186 ◽  
Author(s):  
Jong Oh Kim ◽  
Thiruganesh Ramasamy ◽  
Chul Soon Yong ◽  
Natalia V. Nukolov ◽  
Tatiana K. Bronich ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Advancement in nano pharmaceutical formulation and their biomedical use

2020 ◽  
Vol 10 ◽  
Author(s):  
Dharmendra Kumar ◽  
Rishabha Malviya ◽  
Pramod kumar Sharma ◽  
Akanksha Sharma ◽  
Vineet Bhardwaj
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Polymeric Micelles ◽  
Medical Sciences ◽  
Organic Nanoparticles ◽  
Drug Delivery Carrier ◽  
Block Ionomer Complexes ◽  
Block Ionomer ◽  
Surface Modified ◽  
Surface Modified Nanoparticles

: Nanoparticles and modified nanoparticles are used in biological and medical sciences as liposomes, polymeric micelles, block ionomer complexes, dendrimers, inorganic and organic nanoparticles. Nanoparticles and surface modified nanoparticles are showed good stability and water solubility and can be used efficiently as drug delivery carrier. This paper summarized the advancement in nanoparticles/surface modified nanoparticles and patents based on them.

Effects of Block Length and Structure of Surfactant on Self-Assembly and Solution Behavior of Block Ionomer Complexes

Langmuir ◽  
2000 ◽  
Vol 16 (2) ◽  
pp. 481-489 ◽  
Author(s):  
Tatiana K. Bronich ◽  
Alexei M. Popov ◽  
Adi Eisenberg ◽  
Victor A. Kabanov ◽  
Alexander V. Kabanov
Keyword(s):  
Self Assembly ◽  
Block Length ◽  
Solution Behavior ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Block Ionomer Complexes with Polystyrene Core-Forming Block in Selective Solvents of Various Polarities. 2. Solution Behavior and Self-Assembly in Nonpolar Solvents

2002 ◽  
Vol 35 (16) ◽  
pp. 6344-6350 ◽  
Author(s):  
Eugene A. Lysenko ◽  
Tatiana K. Bronich ◽  
Elena V. Slonkina ◽  
Adi Eisenberg ◽  
Victor A. Kabanov ◽  
...  
Keyword(s):  
Self Assembly ◽  
Solution Behavior ◽  
Selective Solvents ◽  
Nonpolar Solvents ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Toughening Epoxy Thermosets with Block Ionomer Complexes: A Nanostructure–Mechanical Property Correlation

2012 ◽  
Vol 45 (9) ◽  
pp. 3829-3840 ◽  
Author(s):  
Shuying Wu ◽  
Qipeng Guo ◽  
Shuhua Peng ◽  
Nishar Hameed ◽  
Martin Kraska ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Property Correlation ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Block ionomer complexes consisting of siRNA and aRAFT-synthesized hydrophilic-block-cationic copolymers: the influence of cationic block length on gene suppression

2014 ◽  
Vol 5 (24) ◽  
pp. 6967-6976 ◽  
Author(s):  
Andrew C. Holley ◽  
Keith H. Parsons ◽  
Wenming Wan ◽  
Daniel F. Lyons ◽  
G. Reid Bishop ◽  
...  
Keyword(s):  
Block Length ◽  
Gene Suppression ◽  
Cationic Copolymers ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Block Ionomer Complexes with Polystyrene Core-Forming Block in Selective Solvents of Various Polarities. 1. Solution Behavior and Self-Assembly in Aqueous Media

2002 ◽  
Vol 35 (16) ◽  
pp. 6351-6361 ◽  
Author(s):  
Eugene A. Lysenko ◽  
Tatiana K. Bronich ◽  
Elena V. Slonkina ◽  
Adi Eisenberg ◽  
Victor A. Kabanov ◽  
...  
Keyword(s):  
Self Assembly ◽  
Aqueous Media ◽  
Solution Behavior ◽  
Selective Solvents ◽  
Block Ionomer Complexes ◽  
Block Ionomer

scholarly journals Block ionomer complexes of PEG-block-poly(4-vinylbenzylphosphonate) and cationic surfactants as highly stable, pH responsive drug delivery system

2012 ◽  
Vol 160 (3) ◽  
pp. 486-494 ◽  
Author(s):  
Masao Kamimura ◽  
Jong Oh Kim ◽  
Alexander V. Kabanov ◽  
Tatiana K. Bronich ◽  
Yukio Nagasaki
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cationic Surfactants ◽  
Ph Responsive ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Block ionomer complexes containing cationic antibiotics to kill intracellular Brucella melitensis in vitro

2011 ◽  
Vol 23 (11) ◽  
pp. 1484-1493 ◽  
Author(s):  
N. Pothayee ◽  
N. Jain ◽  
T. P. Vadala ◽  
L. M. Johnson ◽  
R. Mejia-Ariza ◽  
...  
Keyword(s):  
Brucella Melitensis ◽  
Block Ionomer Complexes ◽  
Block Ionomer
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