Derivatization LC/MS for the Simultaneous Determination of Fatty Alcohol and Alcohol Ethoxylate Surfactants in Water and Wastewater Samples

2001 ◽  
Vol 35 (6) ◽  
pp. 1223-1230 ◽  
Author(s):  
Jocelyn C. Dunphy ◽  
Daniel G. Pessler ◽  
Stephen W. Morrall ◽  
K. Alex Evans ◽  
David A. Robaugh ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Fatty Alcohol ◽  
Alcohol Ethoxylate ◽  
Water And Wastewater ◽  
Wastewater Samples

Simultaneous Determination of Sildenafil and Tadalafil in Legal Drugs, Illicit/Counterfeit Drugs, and Wastewater Samples by High-Performance Liquid Chromatography

2016 ◽  
Vol 99 (4) ◽  
pp. 923-928 ◽  
Author(s):  
Ali Kemal Fidan ◽  
Sezgin Bakirdere
Keyword(s):  
Simultaneous Determination ◽  
High Performance ◽  
Quantitative Measurement ◽  
Correlation Coefficients ◽  
Wastewater Sample ◽  
Counterfeit Drugs ◽  
Spiking Experiment ◽  
Wastewater Samples ◽  
Erectile Dysfunction Drug

Abstract A sensitive analytical method was developed for the simultaneous determination of sildenafil and tadalafil in legal drugs, illicit/counterfeit drugs, and wastewater samples. Chromatographic separation of two analytes was achieved on a C18 column with a mobile phase including 50 mM phosphate buffer at pH 6.0 and acetonitrile (35 + 65, v/v) at the flow rate of 1.0 mL/min. Analytes were separated from each other in 6 min with high resolution. LOD/LOQ values were calculated as 28/92 ng/mL for sildenafil citrate and 39/129 ng/mL for tadalafil. Calibration plots for both analytes were linear with correlation coefficients >0.9993. A validated method was successfully applied to legal and illicit erectile-dysfunction drug samples consumed in Istanbul, Turkey, and to wastewater samples. Nine different samples were analyzed for qualitative and quantitative measurement of their ingredients, and the results were compared with the values written on the labels of the drugs. The wastewater sample was also analyzed for its sildenafil and tadalafil content. To calculate the recoveries, a spiking experiment was performed and recovery rates for sildenafil and tadalafil were calculated as 101.30 ± 3.43 and 102.68 ± 1.59, respectively.

scholarly journals Optimisation of analytical conditions for simultaneous determination of phenol and chlorophenols by capillary electrophoresis with indirect laser-induced fluorescence detection

2021 ◽  
Vol 63 (11) ◽  
pp. 51-55
Author(s):  
Manh Huy Nguyen ◽  
◽  
Hong Anh Duong ◽  
Hung Viet Pham ◽  
◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Phenolic Compounds ◽  
Simultaneous Determination ◽  
Fluorescence Detection ◽  
Background Electrolyte ◽  
Laser Induced Fluorescence ◽  
Laser Induced Fluorescence Detection ◽  
Electrophoresis Method ◽  
Wastewater Samples

This work presented a capillary electrophoresis method with indirect laser-induced fluorescence detection for the simultaneous determination of phenol and four chlorophenol derivatives. The separation was obtained within 20 minutes with a background electrolyte composed of 5 mM borax and 1 mM fluorescein (pH=9.75), 17 kV of applied voltage, and 120 s of hydrostatic injection. At the optimal conditions, the limit of detections for phenolic compounds was in the range of 0.08-0.23 mg/l, and the RSD data of repeatability and reproducibility were less than 8.0% for both migration times and peak areas. This developed method was applied to analyse concentrations of phenolic compounds in surface water and wastewater samples, with the recoveries ranging from 59.4 to 102.5%.

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