An Electrochemical Study of Antineoplastic Gallium, Iron and Ruthenium Complexes with Redox Noninnocent α-N-Heterocyclic Chalcogensemicarbazones

2008 ◽  
Vol 47 (23) ◽  
pp. 11032-11047 ◽  
Author(s):  
Christian R. Kowol ◽  
Erwin Reisner ◽  
Ion Chiorescu ◽  
Vladimir B. Arion ◽  
Markus Galanski ◽  
...  
Keyword(s):  
Ruthenium Complexes ◽  
Electrochemical Study ◽  
Redox Noninnocent

Trivalent Iron and Ruthenium Complexes with a Redox Noninnocent (2-Mercaptophenylimino)-methyl-4,6-di-tert-butylphenolate(2-) Ligand

2009 ◽  
Vol 48 (8) ◽  
pp. 3783-3791 ◽  
Author(s):  
Nabarun Roy ◽  
Stephen Sproules ◽  
Thomas Weyhermüller ◽  
Karl Wieghardt
Keyword(s):  
Ruthenium Complexes ◽  
Trivalent Iron ◽  
Redox Noninnocent

Ruthenium Complexes of Substituted Terpyridine and Pyridyl-quinoline Based Ligands with Ancillary Ligands: Synthesis, Characterization, Electrochemical Study and DFT Calculation

2016 ◽  
Vol 1 (12) ◽  
pp. 3276-3287 ◽  
Author(s):  
Binitendra N. Mongal ◽  
Sumita Naskar ◽  
Arunava Pal ◽  
Sayantani Bhattacharya ◽  
Tarun K. Mandal ◽  
...  
Keyword(s):  
Dft Calculation ◽  
Ruthenium Complexes ◽  
Electrochemical Study ◽  
Ancillary Ligands

Controlling the Adsorption of Ruthenium Complexes on Carbon Surfaces through Noncovalent Bonding with Pyrene Anchors: An Electrochemical Study

Langmuir ◽  
2016 ◽  
Vol 32 (17) ◽  
pp. 4141-4152 ◽  
Author(s):  
Mayuko Kohmoto ◽  
Hiroaki Ozawa ◽  
Li Yang ◽  
Toshihiro Hagio ◽  
Mariko Matsunaga ◽  
...  
Keyword(s):  
Ruthenium Complexes ◽  
Electrochemical Study ◽  
Carbon Surfaces ◽  
Noncovalent Bonding

Electrochemical study of the influence of H2O2on 316L stainless steel implants in Hank’s solution at body temperatures

2014 ◽  
Vol 102 (1) ◽  
pp. 102
Author(s):  
M. Naoun ◽  
A.B. Bouzida ◽  
N. Bouzeghaia
Keyword(s):  
Stainless Steel ◽  
316L Stainless Steel ◽  
Electrochemical Study ◽  
Body Temperatures ◽  
Hank’S Solution

Solid Supported Ruthenium Complexes for Olefin Metathesis

2013 ◽  
Vol 17 (22) ◽  
pp. 2592-2608 ◽  
Author(s):  
Fatma Hamad ◽  
Cheng Kai ◽  
Yuan Cai ◽  
Yu Xie ◽  
Yin Lu ◽  
...  
Keyword(s):  
Olefin Metathesis ◽  
Ruthenium Complexes

Synthesis and Biological Evaluations of Organoruthenium Scaffolds: A Comprehensive Update

2018 ◽  
Vol 15 (2) ◽  
pp. 179-207
Author(s):  
Ashaparna Mondal ◽  
Priyankar Paira
Keyword(s):  
Singlet Oxygen ◽  
Anticancer Agents ◽  
Ruthenium Complexes ◽  
Chemotherapeutic Agents ◽  
Quantum Yields ◽  
Ros Generation ◽  
Standard Drug ◽  
Cellular Environment ◽  
Theranostic Agents

Background: Currently ruthenium complexes are immerging as effective anticancer agents due to their less toxicity, better antiproliferative and antimetastatic activity, better stability in cellular environment and most importantly variable oxidation and co-ordination states of ruthenium allows binding this molecule with a variety of ligands. So in past few years researchers have shifted their interest towards organoruthenium complexes having good fluorescent profile that may be applicable for cancer theranostics. Nowadays, photodynamic therapy has become more acceptable because of its easy and effective approach towards killing cancer cells. Objective: Objective of this review article is to shed light on synthesis, characterization, stability and fluorescence studies of various ruthenium [Ru(II) and Ru(III)] complexes and different bioactivity studies conducted with the synthesized compounds to test their candidacy as potent chemotherapeutic agents. Methods: Various heterocyclic ligands containing N,O and S as heteroatom mainly were prepared and subjected to complexation with ruthenium-p-cymene moiety. In most cases [Ru(η6-p-cymene)(µ-Cl)Cl]2 was used as ruthenium precursor and the reactions were conducted in various alcohol medium such as methanol, ethanol or propanol. The synthesized complexes were characterized by 1H NMR and 13C NMR spectroscopy, GC-MS, ESI-MS, elemental analysis and single crystal X-ray crystallography methods. Fluorescence study and stability study were conducted accordingly using water, PBS buffer or DMSO. Stable compounds were considered for cell viability studies. To study the efficacy of the compounds in ROS generation as photosensitizers, in few cases, singlet oxygen quantum yields in presence of light were calculated. Suitable compounds were selected for in vitro & in vivo antiproliferative, anti-invasive activity studies. Result: Many newly synthesized compounds were found to have less IC50 compared to a standard drug cysplatin. Those compounds were also stable preferably in physiological conditions. Good fluorescence profile and ROS generation ability were observed for few compounds. Conclusion: Numerous ruthenium complexes were developed which can be used as cancer theranostic agents. Few molecules were synthesized as photosensitizers which were supposed to generate reactive singlet oxygen species in targeted cellular environment in presence of a particular type of light and thereby ceasing cancer cell growth.

Light activation of cyclometalated ruthenium complexes drives towards caspase 3 dependent apoptosis in gastric cancer cells

2020 ◽  
Vol 208 ◽  
pp. 111080 ◽  
Author(s):  
Jorge Andrés Solís-Ruiz ◽  
Anaïs Barthe ◽  
Gilles Riegel ◽  
Rafael Omar Saavedra-Díaz ◽  
Christian Gaiddon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Ruthenium Complexes ◽  
Light Activation ◽  
Gastric Cancer Cells

Impact of the donor substituent on the optoelectrochemical properties of 6H-indolo[2,3-b]quinoxaline amine derivatives

2019 ◽  
Vol 43 (48) ◽  
pp. 19379-19396 ◽  
Author(s):  
Pooja S. Singh ◽  
Purav M. Badani ◽  
Rajesh M. Kamble
Keyword(s):  
Electrochemical Study ◽  
Donor Substituent

An opto-electrochemical study of D–A based indolo-quinoxaline amine derivatives was performed by varying the strength of the amine substituent.

Electrochemical Study of DNA Damaged by Oxidation Stress

2013 ◽  
Vol 16 (2) ◽  
pp. 130-141
Author(s):  
Ondrej Zitka ◽  
Sona Krizkova ◽  
Sylvie Skalickova ◽  
Pavel Kopel ◽  
Petr Babula ◽  
...  
Keyword(s):  
Electrochemical Study ◽  
Oxidation Stress
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