Equilibrium and Kinetic Studies of the Reactive Extraction of Nicotinic Acid with Tri-n-octylamine Dissolved in MIBK

1. The metabolic fate of high dietary intakes of nicotinamide, nicotinic acid and tryptophan, and of acute doses of nicotinamide and nicotinic acid, has been studied in the rat. A new high-pressure liquid chromatography method for measurement of the principal urinary metabolites of niacin is described.2. Administration to rats of a single oral dose of nicotinamide or nicotinic acid (up to 100 mg/kg body-weight), or maintenance for 3 weeks on diets providing 150 mg nicotinamide or nicotinic acid/kg diet, resulted in only a small increase in the liver content of nicotinamide nucleotide coenzymes (NAD and NADP). The quantitative metabolism of nicotinamide and nicotinic acid differed, suggesting that intestinal bacterial deamidation is not the major fate of nicotinamide.3. A high dietary intake of tryptophan (5.9 g/kg diet) led to a considerable increase in liver NAD(P) and also in urinary excretion of niacin metabolites. The results suggest that, as indicated by enzyme kinetic studies (Bender et al. 1982), the utilization of nicotinamide and nicotinic acid for nucleotide synthesis is limited, while there is little or no limitation of NAD(P) synthesis from the tryptophan metabolite quinolinic acid.

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Kinetic Studies of the Reaction of Ferric Soybean Leghemoglobins with Hydrogen Peroxide, Cyanide and Nicotinic Acid

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1980.tb06055.x ◽

2005 ◽

Vol 107 (2) ◽

pp. 491-500 ◽

Cited By ~ 21

Author(s):

Dominique JOB ◽

Boukaré ZEBA ◽

Alain PUPPO ◽

Jean RIGAUD

Keyword(s):

Hydrogen Peroxide ◽

Nicotinic Acid ◽

Kinetic Studies

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Reactive extraction of picolinic and nicotinic acid by natural non-toxic solvent

Separation and Purification Technology ◽

10.1016/j.seppur.2013.10.019 ◽

2013 ◽

Vol 120 ◽

pp. 296-303 ◽

Cited By ~ 33

Author(s):

Mangesh D. Waghmare ◽

Kailas L. Wasewar ◽

Shriram S. Sonawane ◽

Diwakar Z. Shende

Keyword(s):

Nicotinic Acid ◽

Reactive Extraction

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Linear Solvation Energy Relationship Modeling and Kinetic Studies on Reactive Extraction of Succinic Acid by Tridodecylamine Dissolved in MIBK

Biotechnology Progress ◽

10.1021/bp0701968 ◽

2007 ◽

Vol 0 (0) ◽

pp. 0-0 ◽

Cited By ~ 2

Author(s):

I. Inci

Keyword(s):

Succinic Acid ◽

Kinetic Studies ◽

Solvation Energy ◽

Reactive Extraction ◽

Linear Solvation Energy Relationship ◽

Linear Solvation Energy ◽

Linear Solvation

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Kinetics of Reactive Extraction of Pyruvic Acid Using Tributylamine Dissolved in n-Butyl Acetate

International Journal of Chemical Reactor Engineering ◽

10.1515/ijcre-2014-0117 ◽

2015 ◽

Vol 13 (1) ◽

pp. 63-69 ◽

Cited By ~ 8

Author(s):

Dharm Pal ◽

Amit Keshav

Keyword(s):

Aqueous Solution ◽

Rate Constant ◽

Pyruvic Acid ◽

Butyl Acetate ◽

Volume Ratio ◽

Kinetic Studies ◽

Extraction Process ◽

Reactive Extraction ◽

Kinetic Measurements ◽

Kinetics Of

Abstract Studies have been made on the kinetics accompanied with mass transfer for the pyruvic acid/tributylamine (TBA)/n-butyl acetate system to investigate the effectiveness of reactive extraction for the separation of pyruvic acid from the aqueous solution. In the present work, kinetic studies, needed for the design of a recovery unit, were carried out using aqueous solution of pyruvic acid. TBA (conc. range 0.420–2.099 kmol/m3) dissolved in n-butyl acetate (conc. range 50–90%) was used as an extractant. The effect of reactant concentration, the effect of stirring speed and the effect of phase volume ratio on the extraction process were investigated. The kinetic parameters such as reaction order and rate constant were calculated. Kinetic measurements showed that the reaction is of second order occurring in the diffusion film and was found to be independent of hydrodynamic conditions. Rate constant was evaluated to be $0.419\,{{\rm{m}}^3}{\rm{mo}}{{\rm{l}}^{- 1}}{{\rm{S}}^{- 1}}$ .

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Equilibrium & kinetic studies of reactive extraction of trans-aconitic acid using sunflower oil with tri-n-octylamine

International Journal of Chemical Reactor Engineering ◽

10.1515/ijcre-2021-0107 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Rajesh Nimmakayala ◽

Dharm Pal ◽

Dhananjay Singh ◽

Abhinesh Kumar Prajapati

Keyword(s):

Sunflower Oil ◽

Fermentation Broth ◽

Kinetic Studies ◽

Reactive Extraction ◽

Equilibrium Studies ◽

Aconitic Acid ◽

Equilibrium And Kinetics ◽

Loading Ratio ◽

Stirred Cell ◽

Complex Formations

Abstract In order to design an efficient extraction system for the separation of biochemically produced trans-aconitic acid (TAH) from fermentation broth; equilibrium and kinetics of reactive extraction of TAH from aqueous solutions was investigated using tri-n-octylamine (TOA) as an extractant and sunflower oil as a diluent. Through the equilibrium studies stoichiometry (acid, extractant) of complex formations was determined with the help of loading ratio. Formation of (1, 1), (2, 1), & (3, 1) stoichiometry complexes were observed having complexation constants values 179.73 kmol−1 m3, 9512.58 kmol−2 m6, and 614,407.02 kmol−3 m9, respectively. Kinetics experiments were performed in Lewis type stirred cell and results confirmed that reaction between TAH and TOA in sunflower oil fall in regime 1, i.e. slow reaction occurring in bulk organic phase. The overall order of reaction is pseudo first order with rate constant (K mn ) 1.78 × 10−5 (kmol m−3)−0.71 s−1 and physical mass transfer coefficient (K l ) 4.22 × 10−5 m s−1.

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