Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-ResolutionT1Magnetic Resonance Imaging Contrast Agents

2011 ◽  
Vol 133 (32) ◽  
pp. 12624-12631 ◽  
Author(s):  
Byung Hyo Kim ◽  
Nohyun Lee ◽  
Hyoungsu Kim ◽  
Kwangjin An ◽  
Yong Il Park ◽  
...  
Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
María Muñoz-Hernando ◽  
Jesus Ruiz-Cabello ◽  
Fernando Herranz ◽  
Juan Pellico

Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.


2019 ◽  
Vol 167 (2) ◽  
pp. 272-274 ◽  
Author(s):  
M. A. Abakumov ◽  
S. K. Ternovoi ◽  
A. G. Mazhuga ◽  
V. P. Chekhonin ◽  
E. I. Demikhov ◽  
...  

2018 ◽  
Vol 6 (6) ◽  
pp. 1280-1290 ◽  
Author(s):  
Y. Bao ◽  
J. A. Sherwood ◽  
Z. Sun

This review discusses several aspects regarding ultrasmall magnetic nanoparticles asT1contrast agents, including synthesis, parameters affectingT1, and applications.


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