Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

2015 ◽  
Vol 137 (29) ◽  
pp. 9206-9209 ◽  
Author(s):  
Jing Hao ◽  
Petra Kos ◽  
Kejin Zhou ◽  
Jason B. Miller ◽  
Lian Xue ◽  
...  
Keyword(s):  
Ring Opening ◽  
Sirna Delivery ◽  
Ring Opening Polymerization ◽  
Rapid Synthesis

A rapid synthesis of poly (p-dioxanone) by ring-opening polymerization under microwave irradiation

2006 ◽  
Vol 57 (6) ◽  
pp. 873-880 ◽  
Author(s):  
Ying Li ◽  
Xiu-Li Wang ◽  
Ke-Ke Yang ◽  
Yu-Zhong Wang
Keyword(s):  
Microwave Irradiation ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Rapid Synthesis

Controlled ring-opening polymerization of 1,2,6-tricyclic orthoesters of mannose toward size–controlled α-d-mannopyranan

e-Polymers ◽  
2014 ◽  
Vol 14 (6) ◽  
pp. 383-390 ◽  
Author(s):  
Chanokpon Yongyat ◽  
Somsak Ruchirawat ◽  
Siwarutt Boonyarattanakalin
Keyword(s):  
Immune Response ◽  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Ring Opening ◽  
Critical Role ◽  
Monomer Concentration ◽  
Ring Opening Polymerization ◽  
Host Cells ◽  
Rapid Synthesis ◽  
Size Controlled

AbstractLipomannan (LM), one of the major components of glycans found on the cell wall of Mycobacterium tuberculosis, plays a critical role in interacting with host cells and moderating immune response. The backbone of LM is composed of α(1–6) mannopyranan, consisting of approximately 10–15 repeating mannose residues. Rapid synthesis of α(1–6) mannopyranan has been accomplished by ring-opening polymerization using 3,4-O-benzyl-β-d-mannopyranose 1,2,6-orthobenzoate (1) as a starting monomer. Here, we report the progress on attempts to control the size of α(1–6) mannopyranan polymer products. It is possible to prepare α-d-mannopyranan polymer products in different sizes by varying the monomer concentration.

A Recommender System for Inverse Design of Polycarbonates and Polyesters

2020 ◽  
Author(s):  
Nathaniel Park ◽  
Dmitry Yu. Zubarev ◽  
James L. Hedrick ◽  
Vivien Kiyek ◽  
Christiaan Corbet ◽  
...  
Keyword(s):  
Ring Opening ◽  
High Performance ◽  
Recommendation System ◽  
Polymeric Materials ◽  
Monomer Conversion ◽  
Design Strategy ◽  
Ring Opening Polymerization ◽  
Inverse Design ◽  
False Negatives ◽  
Accelerate Development

The convergence of artificial intelligence and machine learning with material science holds significant promise to rapidly accelerate development timelines of new high-performance polymeric materials. Within this context, we report an inverse design strategy for polycarbonate and polyester discovery based on a recommendation system that proposes polymerization experiments that are likely to produce materials with targeted properties. Following recommendations of the system driven by the historical ring-opening polymerization results, we carried out experiments targeting specific ranges of monomer conversion and dispersity of the polymers obtained from cyclic lactones and carbonates. The results of the experiments were in close agreement with the recommendation targets with few false negatives or positives obtained for each class.<br>

Bisurea and Bisthiourea H-Bonding Organocatalysts for Ring-Opening Polymerization: Cues for the Catalyst Design

2019 ◽  
Vol 52 (23) ◽  
pp. 9232-9237 ◽  
Author(s):  
Rukshika S. Hewawasam ◽  
U. L. D. Inush Kalana ◽  
Nayanthara U. Dharmaratne ◽  
Thomas J. Wright ◽  
Timothy J. Bannin ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Catalyst Design

scholarly journals Isoselective Ring-opening Polymerization of Racemic Lactide Catalyzed by N-heterocyclic Olefin/(Thio)urea Organocatalysts

2021 ◽  
Author(s):  
Zhen-Yu Wang ◽  
Guang-Qiang Xu ◽  
Li Zhou ◽  
Cheng-Dong Lv ◽  
Ru-Lin Yang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization
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