scholarly journals Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation

2019 ◽  
Vol 141 (12) ◽  
pp. 4849-4860 ◽  
Author(s):  
Hem Raj Khatri ◽  
Bijay Bhattarai ◽  
Will Kaplan ◽  
Zhongzheng Li ◽  
Marcus John Curtis Long ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity ◽  
Activity Evaluation

Synthesis and Antiinflammatoryand Anticancer Activity Evaluation of Some Condensed Pyrimidines

2000 ◽  
Vol 131 (5) ◽  
pp. 0501-0509 ◽  
Author(s):  
Sham M. Sondhi ◽  
Nidhi Singhal ◽  
Rajeshwar P. Verma ◽  
Sudershan K. Arora ◽  
Rakesh Shukla ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives

2010 ◽  
Vol 45 (2) ◽  
pp. 555-563 ◽  
Author(s):  
Sham M. Sondhi ◽  
Jaiveer Singh ◽  
Reshma Rani ◽  
P.P. Gupta ◽  
S.K. Agrawal ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Acridine Derivatives ◽  
Activity Evaluation ◽  
Anti Inflammatory

scholarly journals Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones

2020 ◽  
pp. 113039
Author(s):  
Lan Luo ◽  
Jing Jing Jia ◽  
Qiu Zhong ◽  
Xue Zhong ◽  
Shilong Zheng ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

Total Synthesis and Anticancer Activity of (+)‐Hypercalin C and Congeners

2019 ◽  
Vol 131 (9) ◽  
pp. 2760-2764 ◽  
Author(s):  
Yongfeng Tao ◽  
Keighley Reisenauer ◽  
Joseph H. Taube ◽  
Daniel Romo
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

Synthesis and anticancer activity evaluation of resveratrol–chalcone conjugates

MedChemComm ◽  
2014 ◽  
Vol 5 (4) ◽  
pp. 528 ◽  
Author(s):  
Deepak Kumar ◽  
K. Kranthi Raj ◽  
Sanjay V. Malhotra ◽  
Diwan S. Rawat
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

ChemInform Abstract: First Total Synthesis of Prasinic Acid and Its Anticancer Activity.

ChemInform ◽  
2013 ◽  
Vol 44 (12) ◽  
pp. no-no
Author(s):  
Narayan Chakor ◽  
Ganesh Patil ◽  
Diana Writer ◽  
Giridharan Periyasamy ◽  
Rajiv Sharma ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation

2020 ◽  
Vol 104 ◽  
pp. 104309
Author(s):  
Anita Bułakowska ◽  
Jarosław Sławiński ◽  
Kamila Siedlecka-Kroplewska ◽  
Grzegorz Stasiłojć ◽  
Marcin Serocki ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

scholarly journals Synthesis and Anticancer Activity Evaluation of Azepinobisindoles; the Isomeric Iheyamine A Derivatives

2019 ◽  
Vol 35 (2) ◽  
pp. 723-731
Author(s):  
Weerachai Phutdhawong ◽  
Sopita Rattanopas ◽  
Jitnapa Sirirak ◽  
Thongchai Taechowisan ◽  
Waya S. Phutdhawong
Keyword(s):  
Anticancer Activity ◽  
Cell Line ◽  
Cell Lines ◽  
Human Cancer ◽  
Docking Study ◽  
Inhibitory Effect ◽  
Molecular Docking Study ◽  
Human Cancer Cell Lines ◽  
Activity Evaluation ◽  
Cancer Line

Azepinobisindole derivatives, the isomeric Iheyamine skeleton, was prepared and its anticancer activity evaluation were investigated against two human cancer cell lines, Hepatocellular carcinoma (HepG2) and human cervical cancer line (Hela) as well as the normal cell line (Vero cell line) using MTT assay. The anticancer activity results indicated that 2-methoxy-5-methyl-5H-azepino[2,3-b:4,5-bʹ]diindole was the most active derivative against tested cell lines. Additionally, molecular docking study in silico the possible inhibitory effect of cyclin-dependent kinase 2 (CDK2) by the azepinoindole revealed that all synthesized compounds fit well in the binding cavity of CDK2.

scholarly journals Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takuya Imaoka ◽  
Makoto Iwata ◽  
Takafumi Akimoto ◽  
Kazuo Nagasawa
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Structural Complexity ◽  
Marine Alkaloids ◽  
Ring Systems ◽  
Agonistic Activity ◽  
Synthetic Approaches

Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.

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