scholarly journals Parallel NMR Supersequences: Ten Spectra in a Single Measurement

JACS Au ◽  
2021 ◽  
Author(s):  
Ēriks Kupče ◽  
Jonathan R. J. Yong ◽  
Göran Widmalm ◽  
Tim D. W. Claridge
Keyword(s):  
Single Measurement

Single measurement of hemoglobin predicts outcome of HCC patients

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
F Finkelmeier ◽  
D Bettinger ◽  
V Köberle ◽  
M Schultheiß ◽  
B Kronenberger ◽  
...  
Keyword(s):  
Single Measurement

Reliability of a Single β-Thromboglobulin Measurement in a Diabetic Population : Importance of PGE1 in Anticoagulant Mixture

1987 ◽  
Vol 57 (02) ◽  
pp. 201-204 ◽  
Author(s):  
P Y Scarabin ◽  
L Strain ◽  
C A Ludlam ◽  
J Jones ◽  
E M Kohner
Keyword(s):  
In Vitro Release ◽  
Mean Value ◽  
Reliable Estimate ◽  
Diabetic Patients ◽  
Single Measurement ◽  
Diabetic Population ◽  
The Difference ◽  
Vitro Release

SummaryDuring the collection of samples for plasma β-thromboglobulin (β-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single β-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE!. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p <0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artifically high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGEi decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

scholarly journals Plasma Rivaroxaban Level to Identify Patients at Risk of Drug Overexposure: Is a Single Measurement of Drug Level Reliable?

TH Open ◽  
2021 ◽  
Vol 05 (01) ◽  
pp. e84-e88
Author(s):  
Krishnan Shyamkumar ◽  
Jack Hirsh ◽  
Vinai C. Bhagirath ◽  
Jeffrey S. Ginsberg ◽  
John W. Eikelboom ◽  
...  
Keyword(s):  
At Risk ◽  
Dose Reduction ◽  
Dose Adjustment ◽  
Trough Level ◽  
Drug Level ◽  
Single Measurement ◽  
Risk Of Bleeding ◽  
Level Measurement ◽  
Patients At Risk ◽  
Trough Levels

Abstract Introduction Dose adjustment based on laboratory monitoring is not routinely recommended for patients treated with rivaroxaban but because an association has been reported between high drug level and bleeding, it would be of interest to know if measuring drug level once could identify patients at risk of bleeding who might benefit from a dose reduction. Objective This study was aimed to investigate the reliability of a single measurement of rivaroxaban level to identify clinic patients with persistently high levels, defined as levels that remained in the upper quintile of drug-level distribution. Methods In this prospective cohort study of 100 patients with atrial fibrillation or venous thromboembolism, peak and trough rivaroxaban levels were measured using the STA-Liquid Anti-Xa assay at baseline and after 2 months. Values of 395.8 and 60.2 ng/mL corresponded to the 80th percentile for peak and trough levels, respectively, and levels above these cut-offs were categorized as high for our analyses. Results Among patients with a peak or trough level in the upper quintile at baseline, only 26.7% (95% confidence interval [CI]: 10.9–52.0%), and 13.3% (95% CI: 2.4–37.9%), respectively, remained above these thresholds. Conclusion Our findings do not support the use of a single rivaroxaban level measurement to identify patients who would benefit from a dose reduction because such an approach is unable to reliably identify patients with high levels.

scholarly journals A New High-Throughput Focused MeV Ion-Beam Analysis Setup

Instruments ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Sören Möller ◽  
Daniel Höschen ◽  
Sina Kurth ◽  
Gerwin Esser ◽  
Albert Hiller ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Rutherford Backscattering Spectrometry ◽  
Ion Beam ◽  
Complete Analysis ◽  
Nuclear Reaction Analysis ◽  
Beam Optics ◽  
Single Measurement ◽  
Ion Beam Analysis ◽  
Beam Analysis ◽  
Technical Solutions

The analysis of material composition by ion-beam analysis (IBA) is becoming a standard method, similar to electron microscopy. A pool of IBA methods exists, from which the combination of particle-induced-X-ray emission (PIXE), particle induced gamma-ray analysis (PIGE), nuclear-reaction-analysis (NRA), and Rutherford-backscattering-spectrometry (RBS) provides the most complete analysis over the whole periodic table in a single measurement. Yet, for a highly resolved and accurate IBA analysis, a sophisticated technical setup is required integrating the detectors, beam optics, and sample arrangement. A new end-station developed and installed in Forschungszentrum Jülich provides these capabilities in combination with high sample throughput and result accuracy. Mechanical tolerances limit the device accuracy to 3% for RBS. Continuous pumping enables 5*10−8 mbar base pressure with vibration amplitudes < 0.1 µm. The beam optics achieves a demagnification of 24–34, suitable for µ-beam analysis. An in-vacuum manipulator enables scanning 50 × 50 mm² sample areas with 10 nm accuracy. The setup features the above-mentioned IBA detectors, enabling a broad range of analysis applications such as the operando analysis of batteries or the post-mortem analysis of plasma-exposed samples with up to 3000 discrete points per day. Custom apertures and energy resolutions down to 11 keV enable separation of Fe and Cr in RBS. This work presents the technical solutions together with the quantification of these challenges and their success in the form of a technical reference.

scholarly journals Measurement of the running of the fine structure constant below 1 GeV with the KLOE detector

2019 ◽  
Vol 218 ◽  
pp. 02012
Author(s):  
Graziano Venanzoni
Keyword(s):  
Fine Structure ◽  
Energy Region ◽  
Direct Evidence ◽  
Branching Ratio ◽  
Structure Constant ◽  
Fine Structure Constant ◽  
Recent Measurement ◽  
Single Measurement ◽  
Lepton Universality ◽  
Hadronic Contribution

I will report on the recent measurement of the fine structure constant below 1 GeV with the KLOE detector. It represents the first measurement of the running of α(s) in this energy region. Our results show a more than 5σ significance of the hadronic contribution to the running of α(s), which is the strongest direct evidence both in time-and space-like regions achieved in a single measurement. From a fit of the real part of Δα(s) and assuming the lepton universality the branching ratio BR(ω → µ+µ−) = (6.6 ± 1.4stat ± 1.7syst) · 10−5 has been determined

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