Separations of Carbohydrates with Noncovalent Shift Reagents by Frequency-Modulated Ion Mobility-Orbitrap Mass Spectrometry

2021 ◽  
Author(s):  
Kristin R. McKenna ◽  
Brian H. Clowers ◽  
Ramanarayanan Krishnamurthy ◽  
Charles L. Liotta ◽  
Facundo M. Fernández
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Orbitrap Mass Spectrometry ◽  
Shift Reagents

Effectiveness and Limitations of Computational Chemistry and Mass Spectrometry in the Rational Design of Target-specific Shift Reagents for Ion Mobility Spectrometry

ChemPhysChem ◽  
2018 ◽  
Vol 19 (21) ◽  
pp. 2921-2930 ◽  
Author(s):  
Christopher Kune ◽  
Jean R. N. Haler ◽  
Johann Far ◽  
Edwin De Pauw
Keyword(s):  
Mass Spectrometry ◽  
Computational Chemistry ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Rational Design ◽  
Shift Reagents

scholarly journals High-Resolution Differential Ion Mobility Separations/Orbitrap Mass Spectrometry without Buffer Gas Limitations

2019 ◽  
Author(s):  
Matthew A. Baird ◽  
Pavel V. Shliaha ◽  
Gordon A. Anderson ◽  
Eugene Moskovets ◽  
Victor Laiko ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Ion Mobility ◽  
Buffer Gas ◽  
Orbitrap Mass Spectrometry

Organic acid shift reagents for the discrimination of carbohydrate isobars by ion mobility-mass spectrometry

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 8008-8015
Author(s):  
Kristin R. McKenna ◽  
Li Li ◽  
Ramanarayanan Krishnamurthy ◽  
Charles L. Liotta ◽  
Facundo M. Fernández
Keyword(s):  
Mass Spectrometry ◽  
Organic Acid ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Mixture Analysis ◽  
Shift Reagents

Traveling wave and drift tube ion mobility were utilized to separate isomeric disaccharides. Organic acid shift reagents were necessary to increase the resolution of these separations for mixture analysis.

scholarly journals Crown ethers as shift reagents in peptide epimer differentiation –conclusions from examination of ac-(H)FRW-NH2 petide sequences

2020 ◽  
Vol 23 (2) ◽  
pp. 177-188
Author(s):  
Magdalena M. Zimnicka
Keyword(s):  
Mass Spectrometry ◽  
Crown Ether ◽  
Crown Ethers ◽  
Ion Mobility ◽  
Ion Source ◽  
Peptide Sequence ◽  
Ion Mobility Mass Spectrometry ◽  
Peptide Molecule ◽  
Shift Reagents ◽  
Specific Association

Abstract Crown ethers with different ring sizes and substituents (18-crown-6, dibenzo-18-crown-6, dicyclohexano-18-crown-6, a chiral tetracarboxylic acid-18-crown-6 ether, dibenzo-21-crown-7, and dibenzo-30-crown-10) were evaluated as shift reagents to differentiate epimeric model peptides (tri-and tetrapeptides) using ion mobility mass spectrometry (IM-MS). The stable associates of peptide epimers with crown ethers were detected and examined using traveling-wave ion mobility time-of-flight mass spectrometer (Synapt G2-S HDMS) equipped with an electrospray ion source. The overall decrease of the epimer separation upon crown ether complexation was observed. The increase of the effectiveness of the microsolvation of a basic moiety - guanidine or ammonium group in the peptide had no or little effect on the epimer discrimination. Any increase of the epimer separation, which referred to the specific association mode between crown substituents and a given peptide sequence, was drastically reduced for the longer peptide sequence (tetrapeptide). The obtained results suggest that the application of the crown ethers as shift reagents in ion mobility mass spectrometry is limited to the formation of complexes differing in stoichiometry rather than it refers to a specific coordination mode between a crown ether and a peptide molecule.

Atmospheric Pressure Drift Tube Ion Mobility–Orbitrap Mass Spectrometry: Initial Performance Characterization

2017 ◽  
Vol 89 (21) ◽  
pp. 11301-11309 ◽  
Author(s):  
Joel D. Keelor ◽  
Stephen Zambrzycki ◽  
Anyin Li ◽  
Brian H. Clowers ◽  
Facundo M. Fernández
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Atmospheric Pressure ◽  
Drift Tube ◽  
Performance Characterization ◽  
Orbitrap Mass Spectrometry

Ion Mobility Spectrometry - High Resolution LTQ-Orbitrap Mass Spectrometry for Analysis of Homemade Explosives

2017 ◽  
Vol 28 (8) ◽  
pp. 1531-1539 ◽  
Author(s):  
Nathan Hagan ◽  
Ilana Goldberg ◽  
Adam Graichen ◽  
Amanda St. Jean ◽  
Ching Wu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Orbitrap Mass Spectrometry

Toward artifact-free data in Hadamard transform-based double multiplexing of ion mobility-Orbitrap mass spectrometry

The Analyst ◽  
2017 ◽  
Vol 142 (10) ◽  
pp. 1735-1745 ◽  
Author(s):  
Meghasyam Tummalacherla ◽  
Sandilya V. B. Garimella ◽  
Spencer A. Prost ◽  
Yehia M. Ibrahim
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Duty Cycle ◽  
Hadamard Transform ◽  
High Duty Cycle ◽  
Free Data ◽  
Orbitrap Mass Spectrometry ◽  
Orbitrap Ms

Algorithm for artifact-free data deconvolution to enable high duty cycle ion mobility-Orbitrap MS.

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