Organic acid shift reagents for the discrimination of carbohydrate isobars by ion mobility-mass spectrometry

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 8008-8015
Author(s):  
Kristin R. McKenna ◽  
Li Li ◽  
Ramanarayanan Krishnamurthy ◽  
Charles L. Liotta ◽  
Facundo M. Fernández
Keyword(s):  
Mass Spectrometry ◽  
Organic Acid ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Mixture Analysis ◽  
Shift Reagents

Traveling wave and drift tube ion mobility were utilized to separate isomeric disaccharides. Organic acid shift reagents were necessary to increase the resolution of these separations for mixture analysis.

scholarly journals Resolving Structural Isomers of Monosaccharide Methyl Glycosides Using Drift Tube and Traveling Wave Ion Mobility Mass Spectrometry

2012 ◽  
Vol 84 (7) ◽  
pp. 3231-3239 ◽  
Author(s):  
Hongli Li ◽  
Kevin Giles ◽  
Brad Bendiak ◽  
Kimberly Kaplan ◽  
William F. Siems ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Structural Isomers ◽  
Traveling Wave Ion Mobility

Comparison of CCS Values Determined by Traveling Wave Ion Mobility Mass Spectrometry and Drift Tube Ion Mobility Mass Spectrometry

2018 ◽  
Vol 90 (20) ◽  
pp. 12042-12050 ◽  
Author(s):  
Vanessa Hinnenkamp ◽  
Julia Klein ◽  
Sven W. Meckelmann ◽  
Peter Balsaa ◽  
Torsten C. Schmidt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Traveling Wave Ion Mobility

High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids

The Analyst ◽  
2015 ◽  
Vol 140 (20) ◽  
pp. 6904-6911 ◽  
Author(s):  
M. Groessl ◽  
S. Graf ◽  
R. Knochenmuss
Keyword(s):  
Mass Spectrometry ◽  
Double Bond ◽  
High Resolution ◽  
Ion Mobility ◽  
Biological Samples ◽  
Drift Tube ◽  
Acyl Chain ◽  
Ion Mobility Mass Spectrometry

Separation and identification of isomeric species is a major challenge in lipidomics. Herein, we demonstrate that lipid isomers that differ only in position of the acyl chain, position of the double bond or double bond geometry can be distinguished using drift-tube ion mobility-mass spectrometry, even in complex biological samples.

scholarly journals Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein

2015 ◽  
Vol 17 (16) ◽  
pp. 10538-10550 ◽  
Author(s):  
Sophie R. Harvey ◽  
Massimiliano Porrini ◽  
Robert C. Tyler ◽  
Cait E. MacPhee ◽  
Brian F. Volkman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Top Down ◽  
Conformational Diversity ◽  
Metamorphic Protein

Ion mobility mass spectrometry can be combined with data from top-down sequencing to discern adopted conformations of proteins in the absence of solvent.

Rapid Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum Using Liquid Chromatography/Drift Tube Ion Mobility-Mass Spectrometry

2019 ◽  
Vol 91 (21) ◽  
pp. 13555-13561 ◽  
Author(s):  
Nicholas R. Oranzi ◽  
Jiajun Lei ◽  
Robin H. J. Kemperman ◽  
Christopher D. Chouinard ◽  
Brett Holmquist ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Serum ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry
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