Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: An in Vitro Study

2012 ◽  
Vol 60 (36) ◽  
pp. 9162-9170 ◽  
Author(s):  
Valentina Furlanetto ◽  
Giuseppe Zagotto ◽  
Riccardo Pasquale ◽  
Stefano Moro ◽  
Barbara Gatto
Keyword(s):  
Ellagic Acid ◽  
Topoisomerase Ii ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ujjal Das ◽  
Sushobhan Biswas ◽  
Sreya Chattopadhyay ◽  
Anindita Chakraborty ◽  
Rakhi Dey Sharma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ellagic Acid ◽  
In Vitro Study ◽  
Carcinoma Cells ◽  
Vitro Study ◽  
Hepatocellular Carcinoma Cells ◽  
Radiosensitizing Effect

scholarly journals Anti-Genotoxicity Evaluation of Ellagic Acid and Curcumin—An In Vitro Study on Zebrafish Blood Cells

2021 ◽  
Vol 11 (17) ◽  
pp. 8142
Author(s):  
Filomena Mottola ◽  
Renata Finelli ◽  
Concetta Iovine ◽  
Maria Carannante ◽  
Marianna Santonastaso ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ellagic Acid ◽  
Blood Cells ◽  
Genome Stability ◽  
In Vitro Study ◽  
Vitro Study ◽  
Blue Dye ◽  
Rapd Pcr

Genotoxicity is the ability of specific substances to cause DNA damage, affecting development, physiology, and reproduction. This is often mediated by induction of oxidative stress. This in vitro study aims to test the ability of two antioxidants, ellagic acid (EA, 100 µM) and curcumin (Cur, 40 µM) to protect zebrafish blood cells from the genotoxic action of benzene (10 µL/mL). Cells were treated for 30, 60, and 90 min with EA or Cur alone and in combination with benzene. The antigenotoxic role of antioxidants was evaluated in terms of cytotoxicity by trypan blue dye, genome stability by RAPD-PCR technique, DNA fragmentation and percentage of apoptotic cells using Comet and Diffusion assay, respectively. The results did not show statistical differences in terms of cell viability, genome stability, DNA damage and apoptosis between cells treated with antioxidants. When zebrafish blood cells were co-incubated with individual antioxidants and benzene, a significant improvement of these parameters was observed in comparison with cells incubated in benzene. Our results suggested that EA and Cur are able to protect zebrafish blood cells against DNA damage and apoptosis caused by mutagenic substance, and laid the foundation for future studies investigating their antigenotoxic potential in DNA oxidative damage therapy.

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark
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