Pine (Pinus morrisonicolaHayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy andO6-Methylguanine-DNA Methyltransferase Expression

2014 ◽  
Vol 62 (43) ◽  
pp. 10458-10467 ◽  
Author(s):  
Chia-Leng Liao ◽  
Chien-Min Chen ◽  
Yan-Zin Chang ◽  
Guang-Yaw Liu ◽  
Hui-Chih Hung ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Methylguanine Dna Methyltransferase ◽  
Human Glioblastoma Cells

scholarly journals Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells

2021 ◽  
Vol 22 (21) ◽  
pp. 11938
Author(s):  
Luca X. Zampieri ◽  
Martina Sboarina ◽  
Andrea Cacace ◽  
Debora Grasso ◽  
Léopold Thabault ◽  
...  
Keyword(s):  
Complex I ◽  
Dna Methyltransferase ◽  
Parp Inhibitor ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Glioblastoma Cells ◽  
Anticancer Activities ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Mitochondrial Complex I Inhibitor

Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid recurrence and the acquisition of resistance to TMZ. Here, initially considering that TMZ is a prodrug whose activation is pH-dependent, we explored the contribution of glioblastoma cell metabolism to TMZ resistance. Using isogenic TMZ-sensitive and TMZ-resistant human glioblastoma cells, we report that the expression of O6-methylguanine DNA methyltransferase (MGMT), which is known to repair TMZ-induced DNA methylation, does not primarily account for TMZ resistance. Rather, fitter mitochondria in TMZ-resistant glioblastoma cells are a direct cause of chemoresistance that can be targeted by inhibiting oxidative phosphorylation and/or autophagy/mitophagy. Unexpectedly, we found that PARP inhibitor olaparib, but not talazoparib, is also a mitochondrial Complex I inhibitor. Hence, we propose that the anticancer activities of olaparib in glioblastoma and other cancer types combine DNA repair inhibition and impairment of cancer cell respiration.

Effect of O6-Substituted Guanine Analogs on O6-methylguanine DNA-methyltransferase Expression and Glioblastoma Cells Viability

2016 ◽  
Vol 13 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Patrick-Denis St-Coeur ◽  
Marc Cormier ◽  
Veronique LeBlanc ◽  
Pier Morin ◽  
Mohamed Touaibia
Keyword(s):  
Dna Methyltransferase ◽  
Glioblastoma Cells ◽  
Methylguanine Dna Methyltransferase

scholarly journals Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

2019 ◽  
Vol Volume 13 ◽  
pp. 1023-1032 ◽  
Author(s):  
Jingren Shi ◽  
Wenli Zhang ◽  
Lu He ◽  
Fanhong Kong ◽  
Meichen Pan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

The cytotoxicity of high-linear energy transfer radiation is reinforced by oxaliplatin in human glioblastoma cells

2007 ◽  
Vol 254 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Sami Benzina ◽  
Frederic Debomy ◽  
Jean-Pierre Bergerat ◽  
Jean-Marc Denis ◽  
John Gueulette ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

Olea europaea leaf extract alters microRNA expression in human glioblastoma cells

2012 ◽  
Vol 138 (11) ◽  
pp. 1831-1844 ◽  
Author(s):  
Berrin Tunca ◽  
Gulcin Tezcan ◽  
Gulsah Cecener ◽  
Unal Egeli ◽  
Secil Ak ◽  
...  
Keyword(s):  
Olea Europaea ◽  
Leaf Extract ◽  
Microrna Expression ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Olea Europaéa

scholarly journals Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells.

2021 ◽  
Author(s):  
Aleksandra Glogowska ◽  
Thatchawan Thanasupawat ◽  
Jason Beiko ◽  
Marshall Pitz ◽  
Sabine Hombach‐Klonisch ◽  
...  
Keyword(s):  
Glioblastoma Cells ◽  
Actin Remodeling ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells
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