Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells

2009 ◽  
Vol 57 (10) ◽  
pp. 4439-4446 ◽  
Author(s):  
Won-Kyo Jung ◽  
Soo-Jin Heo ◽  
You-Jin Jeon ◽  
Chang-Min Lee ◽  
Yeong-Min Park ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Brown Alga ◽  
Microglial Cells ◽  
Inhibitory Effects ◽  
Cox 2 ◽  
Marine Brown Alga

scholarly journals Inhibitory Effects of the Lipophilic Extracts and An Isolated Meroditerpene of Brown Alga in Pasture Weeds in the Eastern Amazon Region

2019 ◽  
Vol 37 ◽  
Author(s):  
C.J.B. RAMOS ◽  
R.R. FONSECA ◽  
A.P.S. SOUZA FILHO ◽  
V.L. TEIXEIRA
Keyword(s):  
Seed Germination ◽  
Brown Alga ◽  
Petri Dish ◽  
Inhibitory Effects ◽  
Mean Values ◽  
Radicle Elongation ◽  
Inhibitory Potential ◽  
Marine Brown Alga ◽  
Germination Bioassays ◽  
Hypocotyl Development

ABSTRACT: Two lipophilic extracts and atomaric acid (1), an isolated natural product, were obtained from the marine brown alga Stypopodium zonale (Dictyotaceae) to identify and characterize their potential inhibitory effects on the seed germination, radicle elongation, and hypocotyl development of the weeds Mimosa pudica and Senna obtusifolia. The extracts were prepared with hexane and dichloromethane, and atomaric acid (1) was isolated from hexane extract by way of conventional chromatographic methods. During a 15 days period, germination bioassays were performed at 25 oC with a 12 h photoperiod, whereas radicle elongation and hypocotyl development were assayed at 25 oC with a 24 h photoperiod. After, Petri dishes 9.0 cm in diameter were coated with qualitative filter paper, 25 seeds were placed in a germination chamber, while six pregerminated seeds were placed in the Petri dish for 2-3 days. After 10 days, radicle and hypocotyl extension were measured; and the inhibitory potential of the extracts was assessed at 10 ppm and that of the atomaric acid at 5, 10, 15, and 20 ppm. In both M. pudica and S. obtusifolia, dichloromethane extract achieved the greatest rates of inhibition during seed germination (34% and 22%, respectively), radical germination (38% and 30%, respectively), and hypocotyl development (29% and 22%, respectively). At a concentration of 20 ppm, atomaric acid (1) also demonstrated reduced inhibitory potential, with mean values of 58.67% for M. pudica and 48.67% for S. obtusifolia.

scholarly journals Inhibitory Effects against Pasture Weeds in Brazilian Amazonia of Natural Products from the Marine Brown Alga Dictyota menstrualis

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801
Author(s):  
Rainiomar Raimundo Fonseca ◽  
Antonio Pedro Silva Souza Filho ◽  
Roberto Campos Villaça ◽  
Valéria Laneuville Teixeira
Keyword(s):  
Brown Alga ◽  
Acetone Extract ◽  
Sulfated Polysaccharides ◽  
Mimosa Pudica ◽  
Inhibitory Effects ◽  
Water Fraction ◽  
Dictyota Menstrualis ◽  
The One ◽  
Tlc Analysis ◽  
Marine Brown Alga

Fractions of the acetone extract and a mixture of two diterpenes from the marine brown alga Dictyota menstrualis were prepared with the aim of identifying potential effects on the germination of seeds and on elongation of the radicle and hypocotyl of the weeds Mimosa pudica and Senna obtusifolia. The bioassay on seed germination was performed in controlled conditions of 25°C temperature and a 12 hour photoperiod, while the one concerning radicle and hypocotyl elongation was performed at the same temperature, though adopting a photoperiod of 24 hours. The results varied according to the receptor species, the fraction utilized, and its concentration. TLC analysis of the fractions and comparison with isolated products indicated that the diterpenes pachydictyol A and isopachydictyol A were the most abundant compounds in fraction HE, whereas the diterpene 6-hydroxy-dichotomano-2, 13-diene-16, 17-dial (3) was the most abundant compound in fractions DC and EA. Analysis of less polar fractions (in n-hexane, dichloromethane and ethyl acetate) revealed values of less than 30% inhibition. On the other hand, the ethanol/water fraction was the most active in all instances. The biological activity of these fractions must be due to the presence of known diterpenes and/or sulfated polysaccharides isolated in earlier studies.

Effect of the marine brown alga Canistrocarpus cervicornis on promastigote forms of Leishmania (L.) amazonensis

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AO Santos ◽  
EA Britta ◽  
T Ueda-Nakamura ◽  
BP Dias Filho ◽  
EM Bianco ◽  
...  
Keyword(s):  
Brown Alga ◽  
Canistrocarpus Cervicornis ◽  
Marine Brown Alga

scholarly journals Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis

2021 ◽  
Vol 22 (3) ◽  
pp. 1205
Author(s):  
Ji Sun Ha ◽  
Hye-Rim Choi ◽  
In Sik Kim ◽  
Eun-A Kim ◽  
Sung-Woo Cho ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Neuronal Apoptosis ◽  
Microglial Cells ◽  
Molecular Pattern ◽  
Extracellular Signal ◽  
Tnf Α ◽  
Cox 2 ◽  
Necrosis Factor ◽  
Microglial Inflammation ◽  
Tlr4 Receptor

S100 calcium-binding protein A8 (S100A8), a danger-associated molecular pattern, has emerged as an important mediator of the pro-inflammatory response. Some S100 proteins play a prominent role in neuroinflammatory disorders and increase the secretion of pro-inflammatory cytokines in microglial cells. The aim of this study was to determine whether S100A8 induced neuronal apoptosis during cerebral hypoxia and elucidate its mechanism of action. In this study, we reported that the S100A8 protein expression was increased in mouse neuronal and microglial cells when exposed to hypoxia, and induced neuroinflammation and neuronal apoptosis. S100A8, secreted from neurons under hypoxia, activated the secretion of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) through phosphorylation of extracellular-signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in microglia. Also, phosphorylation of ERK via the TLR4 receptor induced the priming of the NLRP3 inflammasome. The changes in Cyclooxygenase-2 (COX-2) expression, a well-known inflammatory activator, were regulated by the S100A8 expression in microglial cells. Knockdown of S100A8 levels by using shRNA revealed that microglial S100A8 expression activated COX-2 expression, leading to neuronal apoptosis under hypoxia. These results suggested that S100A8 may be an important molecule for bidirectional microglia-neuron communication and a new therapeutic target for neurological disorders caused by microglial inflammation during hypoxia.

scholarly journals Isolation of Guanosine Diphosphate d-Mannuronic Acid from the Marine Brown Alga, Fucus gardneri Silva

1964 ◽  
Vol 239 (3) ◽  
pp. PC944-PC946
Author(s):  
Tsau-Yen Lin ◽  
W.Z. Hassid
Keyword(s):  
Brown Alga ◽  
Guanosine Diphosphate ◽  
Mannuronic Acid ◽  
Marine Brown Alga

scholarly journals Pathway of Alginic Acid Synthesis in the Marine Brown Alga, Fucus gardneri Silva

1966 ◽  
Vol 241 (22) ◽  
pp. 5284-5297
Author(s):  
Tsau-Yen Lin ◽  
W.Z. Hassid
Keyword(s):  
Brown Alga ◽  
Alginic Acid ◽  
Acid Synthesis ◽  
Marine Brown Alga

Meroditerpenoids from the southern Australian marine brown alga Sargassum fallax

2009 ◽  
Vol 70 (2) ◽  
pp. 250-255 ◽  
Author(s):  
Priyanka Reddy ◽  
Sylvia Urban
Keyword(s):  
Brown Alga ◽  
Marine Brown Alga

Oleic acid reduces lipopolysaccharide-induced expression of iNOS and COX-2 in BV2 murine microglial cells: Possible involvement of reactive oxygen species, p38 MAPK, and IKK/NF-κB signaling pathways

2009 ◽  
Vol 464 (2) ◽  
pp. 93-97 ◽  
Author(s):  
Young Taek Oh ◽  
Jung Yeon Lee ◽  
Jinhwa Lee ◽  
Hocheol Kim ◽  
Kyung-Sik Yoon ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Oleic Acid ◽  
Signaling Pathways ◽  
P38 Mapk ◽  
Reactive Oxygen ◽  
Microglial Cells ◽  
Oxygen Species ◽  
Induced Expression ◽  
Cox 2
Sign in / Sign up

Export Citation Format

Share Document