Increased Growth Inhibitory Effects on Human Cancer Cells and Anti-inflammatory Potency of Shogaols from Zingiber officinale Relative to Gingerols

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

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Inhibitory effects of constituents from Anemarrhena asphodeloides on the growth of human cancer cells

Planta Medica ◽

10.1055/s-0028-1084028 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

SK Lee ◽

HY Min ◽

YJ Kang ◽

JY Hong ◽

EJ Park ◽

...

Keyword(s):

Cancer Cells ◽

Human Cancer ◽

Inhibitory Effects ◽

Human Cancer Cells ◽

Anemarrhena Asphodeloides

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Occurrence of a Taurine Derivative in an Antarctic Glass Sponge

Natural Product Communications ◽

10.1177/1934578x1400900408 ◽

2014 ◽

Vol 9 (4) ◽

pp. 1934578X1400900 ◽

Cited By ~ 5

Author(s):

Marianna Carbone ◽

Laura Núñez-Pons ◽

M. Letizia Ciavatta ◽

Francesco Castelluccio ◽

Conxita Avila ◽

...

Keyword(s):

Antibacterial Activity ◽

Cancer Cells ◽

Natural Product ◽

Human Cancer ◽

In Vitro Growth ◽

Butanol Extract ◽

Human Cancer Cells ◽

Hexactinellid Sponge ◽

Growth Inhibitory

The n-butanol extract of an Antarctic hexactinellid sponge, Anoxycalyx (Scolymastra) joubini, was found to contain a taurine-conjugated anthranilic acid, never reported so far either as a natural product or by synthesis. The compound was inactive against human cancer cells in an in vitro growth inhibitory test, and also showed no antibacterial activity.

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Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone

Molecules ◽

10.3390/molecules24020278 ◽

2019 ◽

Vol 24 (2) ◽

pp. 278 ◽

Cited By ~ 14

Author(s):

Bu Choi

Keyword(s):

Cancer Cells ◽

Tumor Cells ◽

Human Cancer ◽

Cancer Drug ◽

Biochemical Basis ◽

Human Cancer Cells ◽

Anti Cancer ◽

Anti Inflammatory ◽

Natural Agent ◽

Growth Of Tumor

Apple is a rich source of bioactive phytochemicals that help improve health by preventing and/or curing many disease processes, including cancer. One of the apple polyphenols is phloretin [2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone], which has been widely investigated for its antioxidant, anti-inflammatory and anti-cancer activities in a wide array of preclinical studies. The efficacy of phloretin in suppressing xenograft tumor growth in athymic nude mice implanted with a variety of human cancer cells, and the ability of the compound to interfere with cancer cells signaling, have made it a promising candidate for anti-cancer drug development. Mechanistically, phloretin has been reported to arrest the growth of tumor cells by blocking cyclins and cyclin-dependent kinases and induce apoptosis by activating mitochondria-mediated cell death. The blockade of the glycolytic pathway via downregulation of GLUT2 mRNA and proteins, and the inhibition of tumor cells migration, also corroborates the anti-cancer effects of phloretin. This review sheds light on the molecular targets of phloretin as a potential anti-cancer and anti-inflammatory natural agent.

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