Small 9-Alkyl Derivatives of 10-Hydroxycamptothecin with Potent Antitumor Activity in Vitro and in Vivo

2005 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
H. Gao ◽  
M. Huang ◽  
J. Sun ◽  
H. Shen ◽  
W. Lu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Alkyl Derivatives ◽  
Derivatives Of

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

2014 ◽  
Vol 74 ◽  
pp. 742-750 ◽  
Author(s):  
Chengyuan Liang ◽  
Juan Xia ◽  
Dong Lei ◽  
Xiang Li ◽  
Qizheng Yao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Schiff Base Derivatives ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

Amino acid and dipeptide derivatives of daunorubicin. 2. Cellular pharmacology and antitumor activity of L1210 leukemic cells in vitro and in vivo

1980 ◽  
Vol 23 (11) ◽  
pp. 1171-1174 ◽  
Author(s):  
R. Baurain ◽  
M. Masquelier ◽  
D. Deprez-De Campeneere ◽  
A. Trouet
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Leukemic Cells ◽  
Cellular Pharmacology ◽  
Derivatives Of

scholarly journals Research in vivo the qualities of potential antitumor amino-acid derivatives of glycosides of indolocarbazol

2017 ◽  
Vol 16 (4) ◽  
pp. 85-92 ◽  
Author(s):  
I. S. Golubeva ◽  
N. P. Yavorskaya ◽  
O. V. Goryunova
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Optimal Dose ◽  
Amino Acid Derivatives ◽  
Tumor Growth Inhibition ◽  
Active Metabolites ◽  
Derivatives Of ◽  
Potential Antitumor

Background. The addition of active metabolites (in particular, amino acids) to the molecule affects the physicochemical and prodrug properties of derivatives of indolocarbazoles. Using computed chemoinformatics, probability antitumor activity of amino-acid derivatives of glycosides of indolocarbazol (AADGI) is predicted with low probability of their cytotoxic activity in vitro. Based on these data, a study of these compounds in vivo is conducted. Objective: the assessment of AADGI as potential antitumor medications. Materials and methods. Research antitumor activity of AADGI was done using murine tumor models - cervical cancer CC-5. Investigated compounds were injected to mice СВА abdominally 5-times daily with interval of 24 h. Observation of animals were continued till their death. Antitumor effect of compounds was assessed by criteria of tumor growth inhibition and increase in life expectancy of mice comparing to control animals. Results. The optimal dose for these series of compounds was titrated and this dose is 100 mg/kg. Antitumor activity of AADGI was assessed on CC-5. Conclusions. Based on data received we suggest an extended study in vivo of antitumor qualities of selected 5 leader AADGI.

scholarly journals Antitumor activity of derivatives of neplanocin A in vivo and in vitro.

1986 ◽  
Vol 9 (2) ◽  
pp. 202-206 ◽  
Author(s):  
AKIO HOSHI ◽  
MITSUZI YOSHIDA ◽  
MASAAKI IIGO ◽  
REIKO TOKUZEN ◽  
KIYOFUMI FUKUKAWA ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Neplanocin A ◽  
Derivatives Of

Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity

2001 ◽  
Vol 44 (20) ◽  
pp. 3264-3274 ◽  
Author(s):  
Sabrina Dallavalle ◽  
Anna Ferrari ◽  
Barbara Biasotti ◽  
Lucio Merlini ◽  
Sergio Penco ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

In vitro and in vivo evaluation of O-alkyl derivatives of tramadol

2008 ◽  
Vol 18 (5) ◽  
pp. 1674-1680 ◽  
Author(s):  
Liming Shao ◽  
Michael Hewitt ◽  
Thomas P. Jerussi ◽  
Frank Wu ◽  
Scott Malcolm ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Alkyl Derivatives ◽  
Derivatives Of

Diorganotin(IV) derivatives of substituted N-hydroxybenzamides with selective cytotoxicity in vitro and potent antitumor activity in vivo

2014 ◽  
Vol 133 ◽  
pp. 1-7 ◽  
Author(s):  
Yun-lan Li ◽  
Zi-wei Wang ◽  
Pu Guo ◽  
Li Tang ◽  
Rui Ge ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Selective Cytotoxicity ◽  
Derivatives Of

ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES

2019 ◽  
Vol 65 (5) ◽  
pp. 760-765
Author(s):  
Margarita Tyndyk ◽  
Irina Popovich ◽  
A. Malek ◽  
R. Samsonov ◽  
N. Germanov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Human Tumor ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Ehrlich Carcinoma ◽  
In Vivo Experiments

The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control.

Derivatives of Deoxypodophyllotoxin Induce Apoptosis Through Bcl-2/Bax Proteins Expression

2020 ◽  
Vol 20 ◽  
Author(s):  
Ya-Nan Li ◽  
Ni Ning ◽  
Lei Song ◽  
Yun Geng ◽  
Jun-Ting Fan ◽  
...  
Keyword(s):  
Annexin V ◽  
Mtt Method ◽  
Anthriscus Sylvestris ◽  
Anti Tumor Activity ◽  
Derivatives Of ◽  
Toxicity In Vitro ◽  
Ht 29 ◽  
Mcf 7

Background: Deoxypodophyllotoxin, isolated from theTraditional Chinese Medicine Anthriscus sylvestris, is well-known because of its significant antitumor activity with strong toxicity in vitro and in vivo. Objective: In this article, we synthesized a series of deoxypodophyllotoxin derivatives, and evaluated their antitumor effectiveness.Methods:The anti tumor activity of deoxypodophyllotoxin derivatives was investigated by the MTT method. Apoptosis percentage was measured by flow cytometer analysis using Annexin-V-FITC. Results: The derivatives revealed obvious cytotoxicity in the MTT assay by decreasing the number of late cancer cells. The decrease of Bcl-2/Bax could be observed in MCF-7, HepG2, HT-29 andMG-63 using Annexin V-FITC. The ratio of Bcl-2/Bax in the administration group was decreased, which was determined by the ELISA kit. Conclusion: The derivatives of deoxypodophyllotoxin could induce apoptosis in tumor cell lines by influencing Bcl-2/Bax.

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