Non-Peptide Corticotropin-Releasing Hormone Antagonists:  Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines

Argyrios G. Arvanitis; Paul J. Gilligan; Robert J. Chorvat; Robert S. Cheeseman; Thomas E. Christos; Rajagopal Bakthavatchalam; James P. Beck; Anthony J. Cocuzza; Frank W. Hobbs; Richard G. Wilde; Charles Arnold; Dennis Chidester; Matthew Curry; Liqi He; Andrea Hollis; John Klaczkiewicz; Paul J. Krenitsky; Joseph P. Rescinito; Everett Scholfield; Steven Culp; Errol B. De Souza; Lawrence Fitzgerald; Dimitri Grigoriadis; S. William Tam; Y. Nancy Wong; Shiew-Mei Huang; Helen L. Shen

doi:10.1021/jm980222w

Non-Peptide Corticotropin-Releasing Hormone Antagonists: Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines

Journal of Medicinal Chemistry ◽

10.1021/jm980222w ◽

1999 ◽

Vol 42 (5) ◽

pp. 805-818 ◽

Cited By ~ 53

Author(s):

Argyrios G. Arvanitis ◽

Paul J. Gilligan ◽

Robert J. Chorvat ◽

Robert S. Cheeseman ◽

Thomas E. Christos ◽

...

Keyword(s):

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Hormone Antagonists

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Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.02.043 ◽

2009 ◽

Vol 19 (7) ◽

pp. 1986-1990 ◽

Cited By ~ 9

Author(s):

Diane B. Hauze ◽

Murty V. Chengalvala ◽

Joshua E. Cottom ◽

Irene B. Feingold ◽

Lloyd Garrick ◽

...

Keyword(s):

Small Molecule ◽

Gnrh Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Receptor Structure ◽

Structure Activity

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ChemInform Abstract: CONFORMATIONAL PROPERTIES OF CENTRAL NERVOUS SYSTEM ACTIVE THYROTROPIN RELEASING HORMONE ANALOGS: PROBING STRUCTURE-ACTIVITY RELATIONSHIPS AT THE MOLECULAR LEVEL

Chemischer Informationsdienst ◽

10.1002/chin.198521361 ◽

1985 ◽

Vol 16 (21) ◽

Author(s):

E. ECKLE ◽

J. J. STEZOWSKI

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Molecular Level ◽

Thyrotropin Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Conformational Properties ◽

Hormone Analogs

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Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure–activity relationships and insurmountable antagonism

Biochemical Pharmacology ◽

10.1016/j.bcp.2006.07.011 ◽

2006 ◽

Vol 72 (7) ◽

pp. 838-849 ◽

Cited By ~ 24

Author(s):

Susan K. Sullivan ◽

Sam R.J. Hoare ◽

Beth A. Fleck ◽

Yun-Fei Zhu ◽

Christopher E. Heise ◽

...

Keyword(s):

Hormone Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Antagonist Binding ◽

Gonadotropin Releasing Hormone Receptor ◽

Kinetics Of

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Conformational properties of central nervous system active thyrotropin releasing hormone analogs: probing structure-activity relationships at the molecular level

Journal of Medicinal Chemistry ◽

10.1021/jm00379a022 ◽

1985 ◽

Vol 28 (1) ◽

pp. 125-137 ◽

Cited By ~ 14

Author(s):

Emil Eckle ◽

John J. Stezowski

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Molecular Level ◽

Thyrotropin Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Conformational Properties ◽

Hormone Analogs

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Thyroid Hormone Antagonists: Potential Medical Applications and Structure Activity Relationships

Current Medicinal Chemistry ◽

10.2174/092986709788803277 ◽

2009 ◽

Vol 16 (25) ◽

pp. 3258-3266 ◽

Cited By ~ 16

Author(s):

Johan Malm ◽

Mathias Farnegardh ◽

Gary Grover ◽

Paul Ladenson

Keyword(s):

Thyroid Hormone ◽

Medical Applications ◽

Structure Activity Relationships ◽

Structure Activity ◽

Hormone Antagonists

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Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum

Gastroenterology ◽

10.1053/gast.2002.34783 ◽

2002 ◽

Vol 123 (2) ◽

pp. 505-515 ◽

Cited By ~ 48

Author(s):

Michael Wlk ◽

Chi C. Wang ◽

Maria Venihaki ◽

Jennifer Liu ◽

Dezheng Zhao ◽

...

Keyword(s):

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Anti Inflammatory ◽

Hormone Antagonists ◽

Mouse Ileum

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Potential Uses of Corticotropin-Releasing Hormone Antagonists

Annals of the New York Academy of Sciences ◽

10.1196/annals.1367.021 ◽

2006 ◽

Vol 1083 (1) ◽

pp. 239-251 ◽

Cited By ~ 26

Author(s):

E ZOUMAKIS ◽

K. C RICE ◽

P.W GOLD ◽

G. P CHROUSOS

Keyword(s):

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Hormone Antagonists

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Structure-activity relationships in luteinizing hormone-releasing hormone

Journal of Medicinal Chemistry ◽

10.1021/jm00226a008 ◽

1976 ◽

Vol 19 (4) ◽

pp. 492-495 ◽

Cited By ~ 19

Author(s):

Kari U. Prasad ◽

Roger W. Roeske ◽

Frederick L. Weitl ◽

Jesus A. Vilchez-Martinez ◽

Andrew V. Schally

Keyword(s):

Luteinizing Hormone ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: FURTHER STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIPS IN THE C-TERMINAL PART OF LUTEINIZING HORMONE-RELEASING HORMONE

Chemischer Informationsdienst ◽

10.1002/chin.197404387 ◽

1974 ◽

Vol 5 (4) ◽

pp. no-no

Author(s):

M. FUJINO ◽

S. SHINAGAWA ◽

M. OBAYASHI ◽

S. KOBAYASHI ◽

T. FUKUDA ◽

...

Keyword(s):

Luteinizing Hormone ◽

Terminal Part ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity

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Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.038 ◽

2005 ◽

Vol 15 (16) ◽

pp. 3685-3690 ◽

Cited By ~ 9

Author(s):

Zhiqiang Guo ◽

Dongpei Wu ◽

Yun-Fei Zhu ◽

Fabio C. Tucci ◽

Collin F. Regan ◽

...

Keyword(s):

Hormone Receptor ◽

Gonadotropin Releasing Hormone ◽

Receptor Antagonists ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Gonadotropin Releasing Hormone Receptor

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