Bi[5,5-bis(hydroxymethyl)-3-methyl-2-oxomorpholin-3-yl] (BHM-3 dimer). A low toxicity, water-soluble, one-electron reducing agent

1993 ◽  
Vol 58 (26) ◽  
pp. 7355-7363 ◽  
Author(s):  
Giorgio Gaudiano ◽  
Elizabeth Frank ◽  
Michael S. Wysor ◽  
Steven D. Averbuch ◽  
Tad H. Koch
Keyword(s):  
Reducing Agent ◽  
Water Soluble ◽  
Low Toxicity

scholarly journals HISTOCHEMICAL INVESTIGATIONS OF A SILVER METHOD FOR AXONS

1959 ◽  
Vol 7 (2) ◽  
pp. 86-92 ◽  
Author(s):  
R. K. WINKELMANN ◽  
ROBERT W. SCHMIT
Keyword(s):  
Silver Oxide ◽  
Dark Field ◽  
Reducing Agent ◽  
Water Soluble ◽  
Silver Ion ◽  
General Distribution ◽  
Amine Groups ◽  
Solubility Studies ◽  
Sulfite Ion

Silver ion is not specific either in location or in action in the present silver method. Studies with radioactive silver, with the dark-field microscope, and with simple reducing solutions demonstrate a general distribution of silver ion in the impregnated tissue. Copper and mercury may be substituted for silver in the impregnating solution. A water-soluble aldehyde is necessary as a fixative. The substrate for staining appears to require the presence of protein-bound amine groups. The product-forming solution does not require the presence of a reducing agent. Sulfite ion is not necessary. All controllable sources of base that were utilized produced the histologic results. The product appears to be silver oxide in terms of the present solubility studies.

Gram scale synthesis of specialized pro-resolving mediator 17( S )-HDHA using lipoxygenase enhanced by water-soluble reducing agent TCEP

2016 ◽  
Vol 26 (2) ◽  
pp. 343-345 ◽  
Author(s):  
Toshimasa Itoh ◽  
Tomoko Saito ◽  
Yoshinori Yamamoto ◽  
Hiroaki Ishida ◽  
Keiko Yamamoto
Keyword(s):  
Reducing Agent ◽  
Water Soluble

Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging

The Analyst ◽  
2014 ◽  
Vol 139 (7) ◽  
pp. 1692-1696 ◽  
Author(s):  
Weiping Wang ◽  
Ya-Chun Lu ◽  
Hong Huang ◽  
Jiu-Ju Feng ◽  
Jian-Rong Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Soluble Nitrogen ◽  
Facile Synthesis ◽  
Nitrogen Doped ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

A simple and green hydrothermal method was developed for preparation of water-soluble nitrogen-doped carbon dots (N-CDs) from streptomycin. The prepared N-CDs reveal low toxicity, high stability and good biocompatibility, which can be used as fluorescent probes for cell imaging.

Poly(amidoamine) dendrimer-supported organoplatinum antitumour agents

2009 ◽  
Vol 466 (2117) ◽  
pp. 1515-1526 ◽  
Author(s):  
B. A. Howell ◽  
D. Fan
Keyword(s):  
Water Solubility ◽  
High Surface ◽  
Pamam Dendrimer ◽  
Water Soluble ◽  
Antitumour Agents ◽  
Surface Functionality ◽  
Drug Conjugates ◽  
Carboxylate Groups ◽  
Polymeric Prodrug ◽  
Low Toxicity

While numerous water-soluble biocompatible polymers have been utilized for the construction of drug conjugates that offer significant advantages for drug delivery, poly(amidoamine) (PAMAM) dendrimers are superior in many ways for this purpose. They display nanoscale size, uniform shape, excellent water solubility, low toxicity and high surface functionality. In an attempt to circumvent the toxic side effects associated with the administration of organoplatinum drugs, a polymeric prodrug has been prepared from the treatment of a generation 4.5 PAMAM dendrimer with diaquo(1,2-diaminocyclohexane)platinum(II). A well-defined dendrimer–platinum conjugate containing 40 (1,2-diaminocyclohexane)platinum(II) units coordinated to the dendrimer surface via carboxylate groups is formed. This adduct is well behaved, water soluble, contains a high loading of platinum moieties and displays sustained release of active platinum species over a 24 h period under physiological conditions.

scholarly journals THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

2020 ◽  
Vol XXV ◽  
pp. 5-15
Keyword(s):  
Noncovalent Interactions ◽  
Water Soluble ◽  
Production Costs ◽  
Medical Applications ◽  
Covalent Bonds ◽  
Chitosan Derivatives ◽  
Ph Values ◽  
Extended Range ◽  
Low Toxicity ◽  
Physically Crosslinked

This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.

scholarly journals Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid

ACS Omega ◽  
2020 ◽  
Vol 5 (12) ◽  
pp. 6494-6499 ◽  
Author(s):  
Jianghong Zhang ◽  
Xu Yan ◽  
Yunpeng Tian ◽  
Wanyun Li ◽  
Haiyang Wang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Low Toxicity

Novel Water-Soluble Organosilane Compounds as a Radical Reducing Agent in Aqueous Media

1997 ◽  
Vol 70 (10) ◽  
pp. 2519-2523 ◽  
Author(s):  
Osamu Yamazaki ◽  
Hideo Togo ◽  
Genki Nogami ◽  
Masataka Yokoyama
Keyword(s):  
Aqueous Media ◽  
Reducing Agent ◽  
Water Soluble

Bi[3,5-dimethyl-5-(hydroxymethyl)-2-oxomorpholin-3-yl] (DHM-3 dimer). A water-soluble, one-electron reducing agent

1987 ◽  
Vol 52 (14) ◽  
pp. 3073-3081 ◽  
Author(s):  
Giorgio Gaudiano ◽  
Tad H. Koch
Keyword(s):  
Reducing Agent ◽  
Water Soluble

Synthesis, structural characterisation, and cytotoxicity studies of Bi, W, and Mo containing homo- and hetero-bimetallic polyoxometalates

2019 ◽  
Vol 48 (42) ◽  
pp. 15962-15969 ◽  
Author(s):  
Dimuthu C. Senevirathna ◽  
Melissa V. Werrett ◽  
Manja Kubeil ◽  
Holger Stephan ◽  
Philip C. Andrews
Keyword(s):  
Water Soluble ◽  
Embryonic Cells ◽  
Human Carcinoma ◽  
Structural Characterisation ◽  
Cytotoxicity Studies ◽  
Low Toxicity

High nuclearity, water soluble polyoxometalates composed of high Z number metals W, Mo and Bi demonstrate low toxicity to human carcinoma and healthy embryonic cells and their potential as radiosensitisers.

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