Application of Binary Polymer System in Drug Release Rate Modulation. 2. Influence of Formulation Variables and Hydrodynamic Conditions on Release Kinetics

An oral modied release dosage forms have always been more effective therapeutic alternative to conventional dosage forms. The present invention is directed to a modied release pharmaceutical composition of indomethacin by using hydrophilic release retardant polymers like HPMC K15M, Na CMC alone or in combination. Matrix embedded prolong release tablet formulations of Indomethacin were prepared by wet granulation technique and evaluated for tablet properties such as the thickness, hardness, friability, weight variation, drug content, drug release kinetics and in vitro release studies. The inuence of drug polymer ratio on drug release was studied by dissolution test. The FTIR studies showed no interactions among drug and polymers. The tablets formulation (F7 and F8) containing combined polymers of HPMC K15M and Na CMC resulted in slower drug release rate form the matrix. So, it can be concluded that Indomethacin prolong release tablets using HPMC K15M and Na CMC as the retardant has successfully extended the release of indomethacin from its formulations. The mixing of two cellulose polymers, ionic and non-ionic, for the formulation of hydrophilic matrices, resulted in a valuable decrease in drug release rate. All the formulations showed KorsmeyerPeppa’s model as a best t.

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Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Revista de Chimie ◽

10.37358/rc.18.12.6761 ◽

2019 ◽

Vol 69 (12) ◽

pp. 3416-3422

Author(s):

Marilena Petrescu ◽

Raul Augustin Mitran ◽

Cristian Matei ◽

Marius Radulescu ◽

Daniela Berger

Keyword(s):

Side Effects ◽

Drug Release ◽

Mesoporous Silica ◽

Release Rate ◽

Release Kinetics ◽

Alginate Beads ◽

Drug Release Rate ◽

Silica Materials ◽

Mesocellular Foam Silica ◽

Mcm 41

Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.

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Influence of Formulation Variables and Processing Techniques on Drug Release from Carbopol-971 based Matrix Tablets of Cinnarizine and Nimodipine.

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v2i1.8840 ◽

2010 ◽

Vol 2 (1) ◽

Author(s):

Singh K. ◽

Pandit K. ◽

Mishra N.

Keyword(s):

Drug Release ◽

Release Rate ◽

Polymer Concentration ◽

Matrix Tablets ◽

Wet Granulation ◽

Weight Variation ◽

Diffusion Controlled ◽

The Matrix ◽

Processing Techniques ◽

Formulation Variables

The matrix tablets of cinnarizine and nimodipine were prepared with varying ratio of Carbopol- 971P and co-excipients of varying hydrophilicity (i.e. dicalcium phosphate and spray dried lactose) by direct compression and wet granulation using alcoholic mucilage. The prepared tablets were evaluated for weight variation, hardness and friability. The influence of concentration of the matrix forming material and co-excipients on the release rate of the drug was studied. The release rate of Cinnarizine (more soluble drug) from tablets followed diffusion controlled mechanism whereas for nimodipine (less soluble drug), the drug release followed case-II or super case- II transport mechanism based on Korsmeyer- Peppas equation. The results indicated that the drug release from matrix tablets was increases with increase in hydrophilicity of drug and co-excipients. The release of drug also increased with thermal treatment and decreasing polymer concentration.

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Microorganism-based monodisperse microcapsules: encapsulation of the fungicide tebuconazole and its controlled release properties

RSC Advances ◽

10.1039/c5ra01629k ◽

2015 ◽

Vol 5 (32) ◽

pp. 25164-25170 ◽

Cited By ~ 6

Author(s):

Bo Zhang ◽

Teng Zhang ◽

Quanxi Wang ◽

Tianrui Ren

Keyword(s):

Controlled Release ◽

Powdery Mildew ◽

Drug Release ◽

Release Rate ◽

Drug Release Rate ◽

Burst Effect ◽

Initial Burst ◽

Release System ◽

Controlled Release System ◽

Monodisperse Microcapsules

A controlled release system was prepared, it based on UF modified PCC cells in which TEB are loaded into cells. It can control the drug release rate, depress the initial “burst effect”, and was efficacious in controlling wheat powdery mildew.

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