scholarly journals Insight into the Cooperation of P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) at the Blood–Brain Barrier: A Case Study Examining Sorafenib Efflux Clearance

2012 ◽  
Vol 9 (3) ◽  
pp. 678-684 ◽  
Author(s):  
Sagar Agarwal ◽  
William F. Elmquist
Keyword(s):  
Breast Cancer ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Cancer Resistance ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Resistance Protein ◽  
Insight Into

[18F]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood–brain barrier

2015 ◽  
Vol 42 (7) ◽  
pp. 585-589 ◽  
Author(s):  
Thomas Wanek ◽  
Alexander Traxl ◽  
Jens P. Bankstahl ◽  
Marion Bankstahl ◽  
Michael Sauberer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Cancer Resistance ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Resistance Protein ◽  
18F Fdg

scholarly journals Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance–Associated Protein 2 at the Blood–Brain Barrier

2020 ◽  
Vol 128 (3) ◽  
pp. 037002 ◽  
Author(s):  
Ronald E. Cannon ◽  
Alicia C. Richards ◽  
Andrew W. Trexler ◽  
Christopher T. Juberg ◽  
Birandra Sinha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Cancer Resistance ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Resistance Protein

scholarly journals Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP)

2021 ◽  
Vol 22 (11) ◽  
pp. 5534
Author(s):  
Elin Engdahl ◽  
Maarten van Schijndel ◽  
Dimitrios Voulgaris ◽  
Michela Di Criscio ◽  
Kerry Ramsbottom ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bisphenol A ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Production Volume ◽  
Cancer Resistance ◽  
Blood Brain ◽  
Resistance Protein

The breast cancer resistance protein (BCRP) is an important efflux transporter in the blood-brain barrier (BBB), protecting the brain from a wide range of substances. In this study, we investigated if BCRP function is affected by bisphenol A (BPA), a high production volume chemical used in common consumer products, as well as by bisphenol F (BPF) and bisphenol S (BPS), which are used to substitute BPA. We employed a transwell-based in vitro cell model of iPSC-derived brain microvascular endothelial cells, where BCRP function was assessed by measuring the intracellular accumulation of its substrate Hoechst 33342. Additionally, we used in silico modelling to predict if the bisphenols could directly interact with BCRP. Our results showed that BPA significantly inhibits the transport function of BCRP. Additionally, BPA was predicted to bind to the cavity that is targeted by known BCRP inhibitors. Taken together, our findings demonstrate that BPA inhibits BCRP function in vitro, probably by direct interaction with the transporter. This effect might contribute to BPA’s known impact on neurodevelopment.

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