Role of the Na+/K+-ATPase Beta-Subunit in Peptide-Mediated Transdermal Drug Delivery

2015 ◽  
Vol 12 (4) ◽  
pp. 1259-1267 ◽  
Author(s):  
Changli Wang ◽  
Renquan Ruan ◽  
Li Zhang ◽  
Yunjiao Zhang ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Beta Subunit

Transport efficiency in transdermal drug delivery: What is the role of fluid microstructure?

2016 ◽  
Vol 139 ◽  
pp. 294-305 ◽  
Author(s):  
Roberta Liuzzi ◽  
Antonio Carciati ◽  
Stefano Guido ◽  
Sergio Caserta
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Transport Efficiency

scholarly journals Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

2021 ◽  
Vol 4 (1) ◽  
pp. 55-65
Author(s):  
Rabia Gul ◽  
Faryal Jahan ◽  
Faiza Naseer
Keyword(s):  
Drug Delivery ◽  
Chondroitin Sulfate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Joint Destruction ◽  
Therapeutic Outcome ◽  
Penetration Enhancers ◽  
Anti Inflammatory

Osteoarthritis is characterized by joint destruction followed by severe inflammation caused by variety of proinflammatory mediators released due to upregulation of nuclear translocation of nuclear factor (NF-kB). Current treatment involves chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) that is associated with bewildering array of systemic adverse effects. Transdermal drug delivery system address challenges of systemic toxicities but toxic chemical penetration enhancers limit its utility.  Novel drug delivery system explores the potential of bio-inspired materials for designing of safe and effective carriers that specifically deliver drug to site of action with enhanced transdermal penetration of the drug. Chondroitin sulfate, a biopolymer that mimic extracellular matrix, binds specifically with its overexpressed receptors (CD44, RHAMM and ICAM-I) at inflammatory site, biodegradable and possess intrinsic anti-inflammatory properties. These attributes render chondroitin sulfate an ideal carrier for the drug delivery in osteoarthritis. Chondroitin sulfate based nanocarriers serve as a potential drug delivery system that not only deliver anti-arthritis drug through the skin but also produce synergistic effect to improve therapeutic outcome. In this review, molecular mechanism of intrinsic anti-inflammatory effects of chondroitin sulfate in osteoarthritis is discussed in detail. Moreover, potential of chondroitin sulfate to perform dual role of therapeutic agent as well as serve as nanocarrier in transdermal drug delivery for the treatment of osteoarthritis is elaborated. 

Role of Polyvinylpyrrolidone in Dissolving Microneedle for Efficient Transdermal Drug Delivery: In vitro and Clinical Studies

2018 ◽  
Vol 39 (6) ◽  
pp. 789-793 ◽  
Author(s):  
Woo Sun Shim ◽  
Young Min Hwang ◽  
Sun Gyoo Park ◽  
Cheon Koo Lee ◽  
Nae Gyu Kang
Keyword(s):  
Drug Delivery ◽  
Clinical Studies ◽  
Transdermal Drug Delivery

scholarly journals Transdermal drug delivery an emerging approach for antipsychotics

2020 ◽  
Vol 11 (4) ◽  
pp. 5615-5625
Author(s):  
Akash Tekawade ◽  
Tanaji Nandgude
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Oral Drug Delivery ◽  
Skin Penetration ◽  
Barrier Properties ◽  
Oral Drug ◽  
Transdermal Drug Delivery System

Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.

Role of chitosan in transdermal drug delivery

2022 ◽  
pp. 83-105
Author(s):  
Subhash Chander ◽  
Mona Piplani ◽  
Tejashree Waghule ◽  
Gautam Singhvi
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery

Exploring Therapeutic Potential Of Invasomes, Transfersomes, Transethosomes, Oleic Acid Vesicles, And Cubosomes Adopting Topical/Transdermal Route

2021 ◽  
Vol 13 ◽  
Author(s):  
Shivani Verma ◽  
Puneet Utreja
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Transdermal Drug Delivery ◽  
Therapeutic Potential ◽  
Skin Permeation ◽  
Delivery Systems ◽  
Literature Survey ◽  
Sustain Release ◽  
Extensive Degradation

Background: Transdermal drug delivery is considered as a better alternative to oral administration of drugs like proteins or peptides that are susceptible to extensive degradation via first pass metabolism. This delivery route also shows high patient compliance due to no use of painful injections. Conventional delivery systems like creams and gel show poor skin permeation and high dosing frequency. Objective: The objective of this work was to investigate the role of highly advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes for transdermal drug delivery exploring literature survey. Methods: Literature survey for these advanced micro and nanocarrier systems was carried out using search engines like Pubmed and Google scholar. Results: Results of literature investigations revealed that advanced micro and nanocarrier systems discussed earlier have the caliber to enhance skin permeation of various bioactives, show sustain release, and target particular areas of skin better compared to old nanocarriers like liposomes. Conclusion: Present review concludes that advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes are better alternatives for transdermal delivery of therapeutic agents compared to old nanocarriers like liposomes and conventional delivery systems like creams and gels.

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