Microbial Biotransformations. I. O-Demethylation of 7,8-Dimethoxy-2-Methyl-1-(4'-Methoxybenzyl) 1,2,3,4-Tetrahydroisoquinoline By Cunninghamella blakesleeana

1981 ◽  
Vol 44 (4) ◽  
pp. 466-469 ◽  
Author(s):  
Joy B. Reighard ◽  
Paul L. Schiff ◽  
David J. Slatkin ◽  
Joseph E. Knapp
Keyword(s):  
Cunninghamella Blakesleeana

Biotransformation of Glycyrrhetinic Acid by Cunninghamella blakesleeana

2011 ◽  
Vol 8 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Yu-Juan QIN ◽  
Bing FENG ◽  
Xin-Bo SONG ◽  
Wen-Bin ZHOU ◽  
He-Shui YU ◽  
...  
Keyword(s):  
Glycyrrhetinic Acid ◽  
Cunninghamella Blakesleeana

Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana

2021 ◽  
Vol 18 ◽  
Author(s):  
Azizuddin ◽  
Muhammad Iqbal ◽  
Syed Ghulam Musharraf
Keyword(s):  
Double Bond ◽  
Critical Review ◽  
Structural Modification ◽  
Bond Formation ◽  
Environmentally Friendly ◽  
Side Chain ◽  
Synthetic Compounds ◽  
Efficient Approach ◽  
Cunninghamella Blakesleeana ◽  
Different Strains

: For several decades, biotransformational studies on steroidal compounds have gained a lot of attention because it is an efficient approach for the structural modification of complicated natural or synthetic compounds with high regio-, chemo- and stereoselectivity at environmentally friendly conditions. This review summarizes the use of different strains of Cunninghamella blakesleeana for the biotransformation of sixteen steroids 1-16 into a variety of transformed products. The transformed products may be important as a drug or precursor for the production of important pharmaceuticals. The types of reactions performed by C. blakesleeana include hydroxylation, epoxidation, reduction, demethylation, oxidation, glycosidation, double bond formation, side-chain degradation, isomerisation and opening of an isoxazol ring, which would be difficult to produce by traditional synthesis.

Biotransformation of androgenic steroid mesterolone with Cunninghamella blakesleeana and Macrophomina phaseolina

Steroids ◽  
2014 ◽  
Vol 82 ◽  
pp. 53-59 ◽  
Author(s):  
Malik Shoaib Ahmad ◽  
Salman Zafar ◽  
Marium Bibi ◽  
Saira Bano ◽  
Atia-tul-Wahab ◽  
...  
Keyword(s):  
Macrophomina Phaseolina ◽  
Androgenic Steroid ◽  
Cunninghamella Blakesleeana

A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana

2013 ◽  
Vol 136 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Yu Feng ◽  
Min Li ◽  
Jing Liu ◽  
Teng-Yang Xu ◽  
Ruo-Si Fang ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Microbial Transformation ◽  
Cunninghamella Blakesleeana ◽  
One Step

Optimization of the hydroxylation of 2-cyclopentylbenzoxazole with Cunninghamella blakesleeana DSMZ 1906

2000 ◽  
Vol 53 (3) ◽  
pp. 266-271 ◽  
Author(s):  
A. Kraemer-Schafhalter ◽  
S. Domenek ◽  
H. Boehling ◽  
S. Feichtenhofer ◽  
H. Griengl ◽  
...  
Keyword(s):  
Cunninghamella Blakesleeana

Regioselective oxidation of terfenadine with Cunninghamella blakesleeana

2000 ◽  
Vol 10 (1-3) ◽  
pp. 313-324 ◽  
Author(s):  
Günter Schmitz ◽  
Dirk Franke ◽  
Susanne Stevens ◽  
Ralf Takors ◽  
Dirk Weuster-Botz ◽  
...  
Keyword(s):  
Cunninghamella Blakesleeana ◽  
Regioselective Oxidation

scholarly journals Lovastatin Production from Cunninghamella blakesleeana under Solid State Fermentation

2021 ◽  
Author(s):  
Janani Balraj ◽  
Thandeeswaran Murugesan ◽  
Vidhya Kalieswaran ◽  
Karunyadevi Jairaman ◽  
Devippriya Esakkimuthu ◽  
...  
Keyword(s):  
Solid State ◽  
Incubation Period ◽  
Solid State Fermentation ◽  
Carbon Sources ◽  
Experimental Studies ◽  
Nitrogen Sources ◽  
Medium Composition ◽  
Critical Parameters ◽  
Physical Parameters ◽  
Cunninghamella Blakesleeana

Abstract Our earlier paper had established the fact that new soil fungi known as Cunninghamella blakesleeana is potent enough to produce lovastatin significantly. At present, there are no reports on the media optimization for the lovastatin production. Hence, the objective is to optimize the fermentation conditions for lovastatin production by Cunninghamella blakesleeana under Solid State fermentation (SSF) condition through screening the critical factors by one factor at a time and then, optimize the factors selected from screening using statistical approaches. SSF was carried using the pure culture of Cunninghamella blakesleeana KP780148.1 with wheat bran as substrate. Initial screening was performed for physical parameters, carbon sources and nitrogen sources and then optimized the selected parameters through PBD and BBD. Screening result indicated the optimum values of the analysed parameter for the maximal production of lovastatin by Cunninghamella blakesleeana were selected. Out of the nine factors MgSO4, (NH4)2SO4, pH and Incubation period were found to influence the lovastatin production significantly after PBD. The optimal levels of these variables and the effect of their mutual interactions on lovastatin production were determined using BBD surface design. The optimum medium composition was found to be MgSO4(0.2 g/L), (NH4)2 SO4 (12.5 g/L), pH (6) and Incubation period (7 days). Experimental studies showed a yield of 7.39 mg/g at the above optimized conditions which were observed to be very nearby to the predicted value and hence the model was successfully validated. Hence, this is the first report on the optimization of critical parameters for lovastatin production by Cunninghamella blakesleeana.

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