Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata

2015 ◽  
Vol 78 (4) ◽  
pp. 939-943 ◽  
Author(s):  
Chao-Dong Qian ◽  
Fu-Sheng Jiang ◽  
Hang-Su Yu ◽  
Yong Shen ◽  
Yu-Hang Fu ◽  
...  
Keyword(s):  
Bletilla Striata ◽  
Fibrous Roots

Structural characterization and antioxidant activity of a new polysaccharide from Bletilla striata fibrous roots

2020 ◽  
Vol 227 ◽  
pp. 115362 ◽  
Author(s):  
Ziyan Chen ◽  
Yan Zhao ◽  
Mengke Zhang ◽  
Xiufang Yang ◽  
Pengxiang Yue ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Structural Characterization ◽  
Bletilla Striata ◽  
Fibrous Roots

scholarly journals The anti-Staphylococcus aureus activity of the phenanthrene fraction from fibrous roots of Bletilla striata

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jing-Jing Guo ◽  
Bin-Ling Dai ◽  
Ni-Pi Chen ◽  
Li-Xia Jin ◽  
Fu-Sheng Jiang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bletilla Striata ◽  
Fibrous Roots

scholarly journals Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking

2021 ◽  
Author(s):  
Yiyuan Luo ◽  
Juan Wang ◽  
Shuo Li ◽  
Yue Wu ◽  
Zhirui Wang ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Scavenging Activity ◽  
Zebrafish Model ◽  
Bletilla Striata ◽  
Skin Whitening ◽  
Active Constituents ◽  
Fibrous Roots

Abstract Background Bletilla striata was the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and was widely used in cosmetic industry recently. However, its active ingredient was still unclear and its fibrous roots were not used effectively. The aim of the present study was to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking. Methods The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2’-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay. The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish. The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS). Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking. Results The 95% ethanol extract of B. striata fibrous roots (EFB) possesses the strongest DPPH, ABTS, FRAP and tyrosinase inhibition activity, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively. In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) can significantly reduce the melanin synthesis of zebrafish embryos in dose-dependent manner. 39 chemical compositions, including 24 stilbenoids were tentatively identified from EFB and ETB. Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibit stronger binding affinities toward tyrosinase and adenylate cyclase. Conclusion The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.

scholarly journals Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Yiyuan Luo ◽  
Juan Wang ◽  
Shuo Li ◽  
Yue Wu ◽  
Zhirui Wang ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Scavenging Activity ◽  
Zebrafish Model ◽  
Bletilla Striata ◽  
Skin Whitening ◽  
Active Constituents ◽  
Fibrous Roots

Abstract Background Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently. However, its active ingredients are still unclear and its fibrous roots are not used effectively. The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking. Methods The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2′-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay. The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish. The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS). Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking. Results The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively. In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner. 39 chemical compositions, including 24 stilbenoids were tentatively identified from EFB and ETB. Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibited stronger binding affinities toward tyrosinase and adenylate cyclase. Conclusion The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.

The Antibacterial Properties of 4, 8, 4′, 8′-Tetramethoxy (1,1′-biphenanthrene) -2,7,2′,7′-Tetrol from Fibrous Roots of Bletilla striata

2021 ◽  
Vol 61 (2) ◽  
pp. 195-202
Author(s):  
Xue-Jiao Huang ◽  
Nan Xiong ◽  
Bo-Chen Chen ◽  
Fan Luo ◽  
Min Huang ◽  
...  
Keyword(s):  
Antibacterial Properties ◽  
Bletilla Striata ◽  
Fibrous Roots

scholarly journals Protection of Citrus Rootstocks Against Phytophthora spp. with a Hypovirulent Isolate of Phytophthora nicotianae

2007 ◽  
Vol 97 (8) ◽  
pp. 958-963 ◽  
Author(s):  
G. C. Colburn ◽  
J. H. Graham
Keyword(s):  
Poncirus Trifoliata ◽  
Phytophthora Nicotianae ◽  
Root Weight ◽  
Post Inoculation ◽  
Phytophthora Root Rot ◽  
Phytophthora Spp ◽  
Naturally Occurring ◽  
Fibrous Roots ◽  
Cleopatra Mandarin ◽  
Swingle Citrumelo

Phytophthora root rot of citrus in Florida is caused by Phytophthora nicotianae and P. palmivora. A naturally occurring isolate of P. nicotianae (Pn117) was characterized as hypovirulent on citrus roots. Pn117 infected and colonized fibrous roots, but caused significantly less disease than the virulent isolates P. nicotianae Pn198 and P. palmivora Pp99. Coincident inoculation of rootstock seedlings of Cleopatra mandarin (Citrus reticulata) or Swingle citrumelo (C. paradisi × Poncirus trifoliata) with the hypovirulent Pn117 and the virulent isolates Pn198 and Pp99 did not reduce the severity of disease caused by the virulent Phytophthora spp. When either rootstock was inoculated with the hypovirulent Pn117 for 3 days prior to inoculation with virulent isolates, preinoculated seedlings had significantly less disease and greater root weight compared with seedlings inoculated with the virulent isolates alone. Recovery of the different colony types of Phytophthora spp. from roots of sweet orange (C. sinensis) or Swingle citrumelo was evaluated on semiselective medium after sequential inoculations with the hypovirulent Pn117 and virulent Pp99. Pn117 was isolated from roots at the same level as the Pp99 at 3 days post inoculation. Preinoculation of Pn117 for 3 days followed by inoculation with Pp99 resulted in greater recovery of the hypovirulent isolate and lower recovery of the virulent compared with coincident inoculation.

scholarly journals Characterization and Evaluation of the Pro-Coagulant and Immunomodulatory Activities of Polysaccharides from Bletilla striata

ACS Omega ◽  
2020 ◽  
Author(s):  
Wanchen Zhai ◽  
Enwei Wei ◽  
Rui Li ◽  
Tianyi Ji ◽  
Yueyao Jiang ◽  
...  
Keyword(s):  
Bletilla Striata

Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.

Planta Medica ◽  
2021 ◽  
Author(s):  
Hanli Ruan ◽  
Ying Gao ◽  
Ruihua Mao ◽  
Ye Liu ◽  
Ming Zhou
Keyword(s):  
Colorectal Cancer ◽  
Absolute Configuration ◽  
Endophytic Fungus ◽  
Cancer Cell Line ◽  
Ring System ◽  
Ht29 Cell ◽  
Colorectal Cancer Cell Line ◽  
X Ray ◽  
Fibrous Roots ◽  
Trail Sensitivity

Two new cytochalasans with a rare 6/6/5/5/7 pentacyclic ring system, named chaetoconvosins C−D (1−2), together with two known congeners (3−4), were isolated from the fermentation of an endophytic fungus, Chaetomium sp. SG-01, harbored in the fibrous roots of Schisandra glaucescens Diels. Their structures including the absolute configuration were elucidated by extensive spectroscopic (HRESIMS, NMR, and ECD) and X-ray crystallographic analyses. The TRAIL sensitivity of 1–4 in a TRAIL-resistant HT29 colorectal cancer cell line was evaluated, which revealed that co-treatment of 1–4 at 50 µM with TRAIL (150 ng/mL) reduced the HT29 cell viability by 19.0%, 24.1%, 17.9%, and 15.5%, respectively, compared to treatment with 1–4 alone.

Sign in / Sign up

Export Citation Format

Share Document