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A Scalable Oxidation for the Final Stage of Synthesis of Cathepsin K Inhibitor SB-462795
Organic Process Research & Development
◽
10.1021/op100266s
◽
2011
◽
Vol 15
(1)
◽
pp. 123-130
◽
Cited By ~ 8
Author(s):
Steven N. Goodman
◽
Qunying Dai
◽
Jun Wang
◽
William M. Clark
Keyword(s):
Final Stage
◽
Cathepsin K
◽
Cathepsin K Inhibitor
Download Full-text
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References
Faculty Opinions recommendation of Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized, Placebo-Controlled Study.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.737143597.793573698
◽
2020
◽
Author(s):
Susanne Grässel
Keyword(s):
Cathepsin K
◽
Controlled Study
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Cathepsin K Inhibitor
◽
Disease Modifying
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112 EFFECT OF THE SELECTIVE CATHEPSIN K INHIBITOR, MIV-711, ON MARKERS OF CARTILAGE DEGRADATION AND ON GROSS AND HISTOPATHOLOGY SCORES IN DOGS SUBJECTED TO PARTIAL MEDIAL MENISCECTOMY, AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS
Osteoarthritis and Cartilage
◽
10.1016/s1063-4584(11)60139-8
◽
2011
◽
Vol 19
◽
pp. S59
Author(s):
E. Lindstrom
◽
L. Vrang
◽
S. Sedig
◽
Y. Terelius
◽
K. Wikström
◽
...
Keyword(s):
Experimental Model
◽
Cathepsin K
◽
Cartilage Degradation
◽
Cathepsin K Inhibitor
◽
Medial Meniscectomy
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Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis
Bone
◽
10.1016/j.bone.2012.02.598
◽
2012
◽
Vol 50
◽
pp. S188-S189
◽
Cited By ~ 1
Author(s):
E. Lindstrom⁎
◽
L. Vrang
◽
S. Sedig
◽
Y. Terelius
◽
K. Wikström
◽
...
Keyword(s):
Bone Resorption
◽
Knee Joint
◽
Experimental Model
◽
Cathepsin K
◽
Cartilage Degradation
◽
Cathepsin K Inhibitor
◽
Joint Pathology
◽
Medial Meniscectomy
◽
And Cartilage
Download Full-text
Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis
The Journal of Clinical Pharmacology
◽
10.1002/jcph.279
◽
2014
◽
Vol 54
(8)
◽
pp. 937-948
◽
Cited By ~ 4
Author(s):
Chihiro Hasegawa
◽
Helen Kastrissios
◽
Jonathan Monteleone
◽
Tomoya Ohno
◽
Takeo Umemura
◽
...
Keyword(s):
Bone Mineral Density
◽
Modeling And Simulation
◽
Bone Mineral
◽
Cathepsin K
◽
Phase 2
◽
Mineral Density
◽
Dose Selection
◽
Cathepsin K Inhibitor
◽
Phase 2 Study
◽
Density Response
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Letter: The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis
Endocrinology and Metabolism
◽
10.3803/enm.2012.27.1.105
◽
2012
◽
Vol 27
(1)
◽
pp. 105
Author(s):
Sang Ah Lee
Keyword(s):
Bone Mineral Density
◽
Animal Model
◽
Combination Therapy
◽
Bone Mineral
◽
Cathepsin K
◽
Mineral Density
◽
Cathepsin K Inhibitor
Download Full-text
Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis
Osteoarthritis and Cartilage
◽
10.1016/j.joca.2009.03.015
◽
2009
◽
Vol 17
(9)
◽
pp. 1236-1243
◽
Cited By ~ 42
Author(s):
J.R. Connor
◽
C. LePage
◽
B.A. Swift
◽
D. Yamashita
◽
A.M. Bendele
◽
...
Keyword(s):
Cathepsin K
◽
Protective Effects
◽
Cathepsin K Inhibitor
◽
Medial Meniscectomy
Download Full-text
The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis
Journal of Translational Medicine
◽
10.1186/s12967-018-1425-7
◽
2018
◽
Vol 16
(1)
◽
Cited By ~ 12
Author(s):
Erik Lindström
◽
Biljana Rizoska
◽
Karin Tunblad
◽
Charlotte Edenius
◽
Alison M. Bendele
◽
...
Keyword(s):
Animal Models
◽
Experimental Animal
◽
Cathepsin K
◽
Experimental Animal Models
◽
Cathepsin K Inhibitor
◽
Joint Pathology
Download Full-text
Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial
Osteoporosis International
◽
10.1007/s00198-015-3342-4
◽
2015
◽
Vol 27
(1)
◽
pp. 309-318
◽
Cited By ~ 5
Author(s):
R. Eastell
◽
D.-J. Dijk
◽
M. Small
◽
A. Greenwood
◽
J. Sharpe
◽
...
Keyword(s):
Bone Resorption
◽
Postmenopausal Women
◽
Phase 1
◽
Cathepsin K
◽
Phase 1 Trial
◽
Cathepsin K Inhibitor
Download Full-text
Inhibitory effect of cathepsin K inhibitor (ODN-MK-0822) on invasion, migration and adhesion of human breast cancer cells in vitro
Molecular Biology Reports
◽
10.1007/s11033-020-05951-0
◽
2020
◽
Author(s):
Yaongamphi Vashum
◽
Riya Premsingh
◽
Amuthavalli Kottaiswamy
◽
Mathangi Soma
◽
Abirami Padmanaban
◽
...
Keyword(s):
Breast Cancer
◽
Cancer Cells
◽
Human Breast Cancer
◽
Breast Cancer Cells
◽
Cathepsin K
◽
Inhibitory Effect
◽
Human Breast Cancer Cells
◽
Human Breast
◽
Cathepsin K Inhibitor
Download Full-text
Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5year results of a phase 2 trial
Bone
◽
10.1016/j.bone.2012.08.035
◽
2012
◽
Vol 51
(6)
◽
pp. S12
Author(s):
H. Resch
◽
N. Binkley
◽
H. Bone
◽
J.A. Eisman
◽
N. Gilchrist
◽
...
Keyword(s):
Postmenopausal Women
◽
Cathepsin K
◽
Phase 2
◽
Cathepsin K Inhibitor
◽
Phase 2 Trial
Download Full-text
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