Integration of Process Analytical Technology Tools in Pilot-Plant Setups for the Real-Time Monitoring of Crystallizations and Phase Transitions

2013 ◽  
Vol 17 (3) ◽  
pp. 585-598 ◽  
Author(s):  
Lydia Helmdach ◽  
Martin P. Feth ◽  
Joachim Ulrich
Keyword(s):  
Phase Transitions ◽  
Real Time ◽  
Pilot Plant ◽  
Process Analytical Technology ◽  
Real Time Monitoring ◽  
The Real ◽  
Technology Tools ◽  
Analytical Technology

In situ real time monitoring of emulsification and homogenization processes for vaccine adjuvants

The Analyst ◽  
2022 ◽  
Author(s):  
Nicole M. Ralbovsky ◽  
Randal J. Soukup ◽  
Justin P. Lomont ◽  
Mackenzie L. Lauro ◽  
Amanda Gulasarian ◽  
...  
Keyword(s):  
Real Time ◽  
Process Analytical Technology ◽  
Vaccine Adjuvant ◽  
Formation Processes ◽  
Vaccine Adjuvants ◽  
Stable Emulsion ◽  
Real Time Monitoring ◽  
Analytical Technology

Process analytical technology was used to monitor formation of a stable emulsion product, with results providing improved understanding of emulsion-based vaccine adjuvant formation processes.

NIR spectroscopy as a process analytical technology (PAT) tool for on-line and real-time monitoring of an extraction process

2012 ◽  
Vol 58 ◽  
pp. 109-118 ◽  
Author(s):  
Yongjiang Wu ◽  
Ye Jin ◽  
Yerui Li ◽  
Di Sun ◽  
Xuesong Liu ◽  
...  
Keyword(s):  
Real Time ◽  
Process Analytical Technology ◽  
Nir Spectroscopy ◽  
Extraction Process ◽  
Real Time Monitoring ◽  
On Line ◽  
Analytical Technology

scholarly journals Process analytical technology (PAT) as a versatile tool for real-time monitoring and kinetic evaluation of photocatalytic reactions

2020 ◽  
Vol 5 (10) ◽  
pp. 1992-2002
Author(s):  
Martin Rößler ◽  
Philipp U. Huth ◽  
Marcel A. Liauw
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Multivariate Data Analysis ◽  
Process Analytical Technology ◽  
Real Time Monitoring ◽  
Kinetic Evaluation ◽  
Versatile Tool ◽  
Photocatalytic Reactions ◽  
Analytical Technology

Combining in situ Raman spectroscopy with multivariate data analysis enables the real-time monitoring and kinetic evaluation of photocatalytic reactions. The applicability is demonstrated on the photooxidation of 4-methoxythiophenol.

Real-Time Monitoring of Beer Parameters Using Infrared Spectroscopy—A Process Analytical Technology Approach

2020 ◽  
Vol 103 (6) ◽  
pp. 1654-1659
Author(s):  
Simone Tessarini Estevão ◽  
Felipe Rebello Lourenço
Keyword(s):  
Real Time ◽  
Process Analytical Technology ◽  
Partial Least Square ◽  
Least Square ◽  
Partial Least Square Regression ◽  
Real Time Monitoring ◽  
Alcohol Content ◽  
Barley Malt ◽  
Least Square Regression ◽  
Analytical Technology

Abstract Background Quality assessment of a finished beer product is usually performed by determining whether a sample from the batch conforms to the specifications and industry standards. However, if one or more quality parameters do not meet specifications, the batch must be reprocessed or even disposed of entirely. Objective The aim of this work was to propose real-time monitoring of beer parameters using infrared spectroscopy, according to the process analytical technology (PAT) approach. Method Sixteen formulations of beer containing barley malt, rice, maize, and/or oat malt were manufactured and analyzed, using an off-line infrared spectrometer and a beer analyzer, for alcohol content and density. All formulations were also subjected to color analysis, pH measurements, and sensory analysis. Results Partial least square regression models achieved coefficients of determination and prediction of 95.4% and 76.1% for the alcohol content, 90.9% and 69.2% for the density, 93.6% and 85.7% for the pH, and 98.1% and 94.8% for color, respectively. An infrared spectrometric method was used in the real-time monitoring of alcohol content, density, pH, and color of optimized (55% barley malt, 42% oat malt, and 3% maize) and standard (100% barley malt) formulations. Conclusions No statistical differences were observed between the results of the alcoholic content, density, pH, and color predicted by the partial least square regression and those obtained experimentally in the optimized and standard formulations. Highlights The application of the PAT tool is particularly useful for long manufacturing processes and can be applied in the development of food products.

On-line UV-NIR spectroscopy as a process analytical technology (PAT) tool for on-line and real-time monitoring of the extraction process of Coptis Rhizome

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 10078-10085 ◽  
Author(s):  
Xuezhi Dai ◽  
Hang Song ◽  
Wen Liu ◽  
Shun Yao ◽  
Gang Wang
Keyword(s):  
Real Time ◽  
Process Analytical Technology ◽  
Nir Spectroscopy ◽  
Extraction Process ◽  
Real Time Monitoring ◽  
On Line ◽  
Analytical Technology

UV-NIR spectroscopy connected method as a tool for on-line and real-time monitoring of Coptis Rhizome extraction process.

Observing the real time formation of phosphine-ligated gold clusters by electrospray ionization mass spectrometry

2017 ◽  
Vol 19 (26) ◽  
pp. 17187-17198 ◽  
Author(s):  
Marshall R. Ligare ◽  
Grant E. Johnson ◽  
Julia Laskin
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Real Time ◽  
Electrospray Ionization Mass Spectrometry ◽  
Gold Cluster ◽  
Gold Clusters ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Real Time Monitoring ◽  
The Real

Real-time monitoring of the gold cluster synthesis by electrospray ionization mass spectrometry reveals distinct formation pathways for Au8, Au9 and Au10 clusters.

Near infrared and Raman spectroscopy as Process Analytical Technology tools for the manufacturing of silicone-based drug reservoirs

2011 ◽  
Vol 699 (1) ◽  
pp. 96-106 ◽  
Author(s):  
J. Mantanus ◽  
E. Rozet ◽  
K. Van Butsele ◽  
C. De Bleye ◽  
A. Ceccato ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Technology Tools ◽  
Infrared And Raman Spectroscopy ◽  
Analytical Technology
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