The role of oxidative processes in metal carcinogenesis

SummaryAtherothrombosis is the major determinant of acute ischaemic cardiovascular events, such as myocardial infarction and stroke. Inflammatory processes have been linked to all phases of atherogenesis In particular, the identification of autoimmunity mediators in the complex microenvironment of chronic inflammation has become the focus of attention in both early and advanced atherogenic processes. Autoantibodies against self-molecules or new epitopes generated by oxidative processes infiltrate atherosclerotic plaques and were shown to modulate the activity of immune cells by binding various types of receptors. However, despite mounting evidence for a pathophysiological role of autoantibodies in atherothrombosis, the clinical relevance for circulating autoantibodies in cardiovascular outcomes is still debated. This review aims at illustrating the mechanisms by which different types of autoantibodies might either promote or repress atherothrombosis and to discuss the clinical studies assessing the role of auto-antibodies as prognostic biomarkers of plaque vulnerability.

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Palladium(II) tert-butyl peroxide carboxylates. New reagents for the selective oxidation of terminal olefins to methyl ketones. The role of peroxymetalation in selective oxidative processes

Journal of the American Chemical Society ◽

10.1021/ja00523a023 ◽

1980 ◽

Vol 102 (3) ◽

pp. 1047-1054 ◽

Cited By ~ 143

Author(s):

Hubert Mimoun ◽

Robert Charpentier ◽

Andre Mitschler ◽

Jean Fischer ◽

Raymond Weiss

Keyword(s):

Selective Oxidation ◽

Methyl Ketones ◽

Tert Butyl ◽

Butyl Peroxide ◽

Oxidative Processes ◽

Terminal Olefins

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Free radicals, lipid peroxidation and sperm function

Reproduction Fertility and Development ◽

10.1071/rd9950659 ◽

1995 ◽

Vol 7 (4) ◽

pp. 659 ◽

Cited By ~ 393

Author(s):

RJ Aitken

Keyword(s):

Reactive Oxygen Species ◽

Lipid Peroxidation ◽

Reactive Oxygen ◽

Human Spermatozoa ◽

Sperm Function ◽

Oxygen Species ◽

Normal Sperm ◽

Oxidative Processes ◽

Mammalian Spermatozoa

The cellular generation of reactive oxygen species was first observed in mammalian spermatozoa in the late 1940s. The field then remained dormant for 30 years until Thaddeus Mann and Roy Jones published a series of landmark papers in the 1970s in which the importance of lipid peroxidation as a mechanism for damaging mammalian spermatozoa was first intimated. The subsequent demonstration that human spermatozoa produce reactive oxygen species and are susceptible to peroxidative damage has triggered intense interest in the role of oxidative stress in the aetiology of male infertility. Moreover, data have recently been obtained to indicate that, although excessive exposure to reactive oxygen species may be harmful to spermatozoa, in physiological amounts these molecules are of importance in the control of normal sperm function. This review considers the dualistic role of reactive oxygen species and sets out the current understanding of the importance of oxidative processes in both the physiology and the pathology of the human spermatozoon. Extra keywords: human spermatozoa, reactive oxygen species.

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Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions

Experimental Gerontology ◽

10.1016/s0531-5565(00)00112-1 ◽

2000 ◽

Vol 35 (4) ◽

pp. 445-451 ◽

Cited By ~ 107

Author(s):

T Lynch

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Metal Interactions ◽

Oxidative Processes

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THE ROLE OF HEME PIGMENTS AND NITRITE IN OXIDATIVE PROCESSES IN MEAT

Warmed-over Flavor of Meat ◽

10.1016/b978-0-12-661605-7.50008-7 ◽

1987 ◽

pp. 119-139 ◽

Cited By ~ 6

Author(s):

Jay B. Fox ◽

Robert C. Benedict

Keyword(s):

Oxidative Processes

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Role of Antiozonants in Modern Tire Compounding

Rubber Chemistry and Technology ◽

10.5254/1.3540394 ◽

1964 ◽

Vol 37 (4) ◽

pp. 973-989 ◽

Cited By ~ 2

Author(s):

E. R. Thornley

Keyword(s):

Natural Rubber ◽

Antioxidant Properties ◽

Good Deal ◽

Partial Replacement ◽

Protective Agents ◽

Rubber Compounds ◽

Heat Degradation ◽

Protective System ◽

Oxidative Processes

Abstract The need to provide tire compounds with improved resistance to ozone has been very largely met by the use of N,N′ disubstituted-p-phenylenediamines as protective agents. These chemicals are for this reason commonly thought of as antiozonants but they also possess important antioxidant properties and in considering their role in modern compounding, it is necessary to distinguish between their antiozonant and antioxidant functions. The choice of protective system used in any particular tire component depends a good deal on the nature of the polymer. The relative behavior of natural rubber and SBR with respect to ozone cracking and flexcracking is demonstrated by data given in the paper and it is shown how a typical “antiozonant” such as isopropyl phenyl-p-phenylenediamine (IPPD) will protect SBR tread and sidewall compounds principally from static and dynamic ozone cracking and natural rubber compounds not only from ozone attack but also from various oxidative processes such as flexcracking, cut-growth and heat degradation. The effects of the partial replacement of natural rubber and SBR by polybutadiene on the antiozonant and antioxidant requirements of such tire compounds are also briefly considered.

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