Attomole Detection of3H in Biological Samples Using Accelerator Mass Spectrometry:  Application in Low-Dose, Dual-Isotope Tracer Studies in Conjunction with14C Accelerator Mass Spectrometry

1998 ◽  
Vol 11 (10) ◽  
pp. 1217-1222 ◽  
Author(s):  
Karen H. Dingley ◽  
Mark L. Roberts ◽  
Carol A. Velsko ◽  
Kenneth W. Turteltaub
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Biological Samples ◽  
Low Dose ◽  
Tracer Studies ◽  
Dual Isotope ◽  
Isotope Tracer ◽  
Mass Spectrometry Application

Accelerator mass spectrometry: application to study of aluminum kinetics in the rat

1991 ◽  
Vol 260 (3) ◽  
pp. F466-F469 ◽  
Author(s):  
O. Meirav ◽  
R. A. Sutton ◽  
D. Fink ◽  
R. Middleton ◽  
J. Klein ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Renal Clearance ◽  
Intravenous Injection ◽  
Accelerator Mass Spectrometry ◽  
Ultrasensitive Detection ◽  
Tracer Studies ◽  
Isotope Tracer ◽  
Tracer Dose ◽  
Normal Rat ◽  
Mass Spectrometry Application

The advent of accelerator mass spectrometry (AMS) now permits the ultrasensitive detection of extremely long-lived isotopes, including 14C, 26Al, and 41Ca. Until now, tracer studies of aluminum kinetics have not been possible because aluminum has only two isotopes, with half-lives of 6.5 min (29Al) and 7 x 10(5) yr (26Al), neither of which is suitable for conventional studies. In a novel experiment we have employed AMS to study aluminum kinetics in a normal rat and a 5/6-nephrectomized rat over a 3-wk period of intravenous injection of a tracer dose of 26Al. Kinetics were similar in the two animals; approximately 75% of intravenously injected tracer 26Al was excreted in the urine in the first 24 h as was approximately 80% after 3 wk. Renal clearance of 26Al was approximately 0.75 ml.min-1.kg body wt-1 in both rats. The results clearly demonstrate the potential of this technique for isotope tracer studies in animals as well as in humans.

scholarly journals Radiocarbon with Gas Chromatography

Radiocarbon ◽  
1995 ◽  
Vol 37 (2) ◽  
pp. 711-716 ◽  
Author(s):  
Christopher Bronk Ramsey ◽  
R. E. M. Hedges
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Pilot Study ◽  
Accelerator Mass Spectrometry ◽  
Ion Source ◽  
Tracer Studies ◽  
Chemical Fractions ◽  
Peak Sensitivity ◽  
Accelerator System

In 14C tracer studies, and when looking for modern contamination in archaeological samples, it is often necessary to measure the 14C concentration of individual chemical fractions. Gas chromatography (GC) is one method that is frequently used for separation of chemical fractions. The gas ion source at the Oxford Radiocarbon Accelerator Unit for accelerator mass spectrometry (AMS) provides the opportunity to measure fractions from a GC instrument directly. Although the first investigations are likely to be 14C tracer studies, such a GC-AMS system could find much wider application. We present results from a pilot study of the peak sensitivity, baseline stability and crosstalk of the accelerator system used in this way. We also discuss the practical considerations in developing a GC-AMS instrument for routine use.

Genotoxic effects of low-dose exposure to pirimicarb studied with accelerator mass spectrometry

1997 ◽  
Vol 42 (19) ◽  
pp. 1662-1664 ◽  
Author(s):  
Jinyuan Shi ◽  
Haifang Wang ◽  
Xiaohong Wu ◽  
Xinsong Li ◽  
Yuanfang Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Low Dose ◽  
Genotoxic Effects

scholarly journals Accelerator mass spectrometry of small biological samples

2008 ◽  
Vol 22 (23) ◽  
pp. 3928-3934 ◽  
Author(s):  
Mehran Salehpour ◽  
Niklas Forsgard ◽  
Göran Possnert
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Biological Samples

scholarly journals Measurement of Beryllium in Biological Samples by Accelerator Mass Spectrometry:  Applications for Studying Chronic Beryllium Disease

2004 ◽  
Vol 17 (12) ◽  
pp. 1614-1620 ◽  
Author(s):  
Marina L. Chiarappa-Zucca ◽  
Robert C. Finkel ◽  
Roger E. Martinelli ◽  
Jeffery E. McAninch ◽  
David O. Nelson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Biological Samples ◽  
Chronic Beryllium Disease ◽  
Beryllium Disease
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