Accelerator mass spectrometry of small biological samples

Processing and measurement of 200 biomedical samples has provided an opportunity to better understand the characteristics of accelerator mass spectrometry (AMS) analysis of such samples. We have utilized established procedures (Vogel 1992) and developed new methods for handling various biological samples. We have included secondary standards of known isotope ratio for all assays. A method of determining maximum precision for each unknown sample value is also reported. The presented data are an update of the ongoing radiocarbon AMS biomedical program at Purdue University.

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Accelerator mass spectrometry

AccessScience ◽

10.1036/1097-8542.002750 ◽

2015 ◽

Keyword(s):

Mass Spectrometry ◽

Accelerator Mass Spectrometry

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Simultaneous determination of seven aconitum alkaloids in biological samples by liquid chromatography-linear ion trap multistage mass spectrometry coupled with on-line solid phase extraction

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2015.10044 ◽

2016 ◽

Vol 34 (3) ◽

pp. 249

Author(s):

Dingji ZHU ◽

Minping LU ◽

Kejian HUANG ◽

Zhe ZHOU ◽

Cuiwu LIN ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Solid Phase Extraction ◽

Biological Samples ◽

Ion Trap ◽

Solid Phase ◽

Linear Ion Trap ◽

Phase Extraction ◽

On Line

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Hiatus in Prehistoric Chronology of the Cis-Baikal Region, Siberia: Pattern or Artifact?

Radiocarbon ◽

10.1017/s0033822200041953 ◽

2007 ◽

Vol 49 (1) ◽

pp. 123-129 ◽

Cited By ~ 2

Author(s):

Yaroslav V Kuzmin

Keyword(s):

Mass Spectrometry ◽

Accelerator Mass Spectrometry ◽

Baikal Region ◽

Critical Evaluation ◽

Burial Grounds

The problem of a hiatus at about 6100–5300 BP (about 4900–4200 cal BC) in the prehistoric chronology of the Cis-Baikal region in Siberia is discussed. Based on a critical evaluation of existing evidence, there was no discontinuity found in the cultural sequence between the Kitoi and Serovo/Glazkovo complexes of the Neolithic, and the proposed “hiatus” may be an artifact based on underestimation of solid data. Conventional 14C dates are presented that were generated in the 1980s to early 2000s for Cis-Baikal prehistoric burial grounds, and were later dated by the accelerator mass spectrometry (AMS).

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14C INTERCOMPARISON EXERCISE ON BONES AND IVORY SAMPLES: IMPLICATIONS FOR FORENSICS

Radiocarbon ◽

10.1017/rdc.2020.142 ◽

2021 ◽

pp. 1-12

Author(s):

G Quarta ◽

M Molnár ◽

I Hajdas ◽

L Calcagnile ◽

I Major ◽

...

Keyword(s):

Mass Spectrometry ◽

International Atomic Energy Agency ◽

Accelerator Mass Spectrometry ◽

Reference Curve ◽

Nuclear Testing ◽

Energy Agency ◽

Widespread Application ◽

Intercomparison Exercise ◽

High Degree ◽

Data Calibration

ABSTRACT The application of accelerator mass spectrometry radiocarbon (AMS 14C) dating in forensics is made possible by the use of the large excursion of the 14C concentration in the post-WWII terrestrial atmosphere due to nuclear testing as a reference curve for data calibration. By this approach high-precision analyses are possible on samples younger than ∼70 years. Nevertheless, the routine, widespread application of the method in the practice of forensics still appears to be limited by different issues due to possible complex interpretation of the results. We present the results of an intercomparison exercise carried out in the framework of an International Atomic Energy Agency (IAEA) CRP-Coordinated Research Project between three AMS laboratories in Italy, Hungary, and Switzerland. Bone and ivory samples were selected with ages spanning from background (>50 ka) to 2018. The results obtained allow us to assess the high degree of reproducibility of the results and the remarkable consistency of the experimental determinations.

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Ion Mobility–Mass Spectrometry for Bioanalysis

Separations ◽

10.3390/separations8030033 ◽

2021 ◽

Vol 8 (3) ◽

pp. 33

Author(s):

Xavier Garcia ◽

Maria del Mar Sabaté ◽

Jorge Aubets ◽

Josep Maria Jansat ◽

Sonia Sentellas

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

Biological Samples ◽

Ion Mobility Mass Spectrometry ◽

Exogenous Compounds ◽

Analytical Separation

This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

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