Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies

2011 ◽  
Vol 83 (14) ◽  
pp. 5607-5616 ◽  
Author(s):  
Lan Gao ◽  
Jing Li ◽  
Claudia Kasserra ◽  
Qi Song ◽  
Ali Arjomand ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Accelerator Mass Spectrometry ◽  
Biological Samples ◽  
Absolute Bioavailability ◽  
Precision And Accuracy ◽  
Mass Spectrometry Application

Accelerator mass spectrometry: application to study of aluminum kinetics in the rat

1991 ◽  
Vol 260 (3) ◽  
pp. F466-F469 ◽  
Author(s):  
O. Meirav ◽  
R. A. Sutton ◽  
D. Fink ◽  
R. Middleton ◽  
J. Klein ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Renal Clearance ◽  
Intravenous Injection ◽  
Accelerator Mass Spectrometry ◽  
Ultrasensitive Detection ◽  
Tracer Studies ◽  
Isotope Tracer ◽  
Tracer Dose ◽  
Normal Rat ◽  
Mass Spectrometry Application

The advent of accelerator mass spectrometry (AMS) now permits the ultrasensitive detection of extremely long-lived isotopes, including 14C, 26Al, and 41Ca. Until now, tracer studies of aluminum kinetics have not been possible because aluminum has only two isotopes, with half-lives of 6.5 min (29Al) and 7 x 10(5) yr (26Al), neither of which is suitable for conventional studies. In a novel experiment we have employed AMS to study aluminum kinetics in a normal rat and a 5/6-nephrectomized rat over a 3-wk period of intravenous injection of a tracer dose of 26Al. Kinetics were similar in the two animals; approximately 75% of intravenously injected tracer 26Al was excreted in the urine in the first 24 h as was approximately 80% after 3 wk. Renal clearance of 26Al was approximately 0.75 ml.min-1.kg body wt-1 in both rats. The results clearly demonstrate the potential of this technique for isotope tracer studies in animals as well as in humans.

scholarly journals Accelerator mass spectrometry of small biological samples

2008 ◽  
Vol 22 (23) ◽  
pp. 3928-3934 ◽  
Author(s):  
Mehran Salehpour ◽  
Niklas Forsgard ◽  
Göran Possnert
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Biological Samples
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