Necrosis of the leg after intraarterial drug injection

VASA ◽  
2011 ◽  
Vol 40 (2) ◽  
pp. 163-166 ◽  
Author(s):  
Betz ◽  
Steinbauer ◽  
Uhl ◽  
Toepel

Inadvertent intraarterial injections in the context of drug abuse can cause damage to the vascular system. The clinical picture depends on the drug properties and ranges from partial ischemia to necrosis of the affected extremity. There are no current evidence-based guidelines regarding the management of intraarterial drug injections. In many cases the concept of solving vasospasm after injection is based on the use of intraarterial application of prostaglandins. We report a case in which a mixture of drugs was injected into the left femoral artery. The patient arrived 24 hours later with ischemia of the left leg at our emergency department. Angiography showed that there was no blood flowing in the leg. Despite intraarterial application of vasodilatators, regional neurolysis and thrombolyis with urokinase major amputation was unavoidable. The outcome after inadvertent injection depends on certain drug properties and the delay between injection and the beginning of therapy.

2020 ◽  
Vol 16 (3) ◽  
Author(s):  
Adam K Stanley ◽  
Ashton Barnett-Vanes ◽  
Matthew J Reed

Over a billion Peripheral Intra-Venous Cannulas (PIVC) are used globally every year with at least 25 million sold annually in the UK.1,2 The NHS spends an estimated £29m of its annual acute sector budget on PIVC procurement3 and around 70% of all hospitalised patients require at least one PIVC during their stay.4 Despite their extensive and routine use, PIVC failure rates are reported as high as 50-69%.5-7 In addition, many PIVCs remain unused following insertion, particularly in the Emergency Department (ED).8,9 The risk factors for PIVC failure are not well understood and the literature has found extensive regional variation in practice when it comes to PIVC insertion and management.1,7,10 While various technologies have been developed to address these issues, there remains a need for standardised, evidence-based guidelines.


CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S105-S106
Author(s):  
P. Doran ◽  
G. Sheppard ◽  
B. Metcalfe

Introduction: Canadians are the second largest consumers of prescription opioids per capita in the world. Emergency physicians tend to prescribe stronger and larger quantities of opioids, while family physicians write the most opioid prescriptions overall. These practices have been shown to precipitate future dependence, toxicity and the need for hospitalization. Despite this emerging evidence, there is a paucity of research on emergency physicians’ opioid prescribing practices in Canada. The objectives of this study were to describe our local emergency physicians’ opioid prescribing patterns both in the emergency department and upon discharge, and to explore factors that impact their prescribing decisions. Methods: Emergency physicians from two urban, adult emergency departments in St. John's, Newfoundland were anonymously surveyed using a web-based survey tool. All 42 physicians were invited to participate via email during the six-week study period and reminders were sent at weeks two and four. Results: A total of 21 participants responded to the survey. Over half of respondents (57.14%) reported that they “often” prescribe opioids for the treatment of acute pain in the emergency department, and an equal number of respondents reported doing so “sometimes” at discharge. Eighty-five percent of respondents reported most commonly prescribing intravenous morphine for acute pain in the emergency department, and over thirty-five percent reported most commonly prescribing oral morphine upon discharge. Patient age and risk of misuse were the most frequently cited factors that influenced respondents’ prescribing decisions. Only 4 of the 22 respondents reported using evidence-based guidelines to tailor their opioid prescribing practices, while an overwhelming majority (80.95%) believe there is a need for evidence-based opioid prescribing guidelines for the treatment of acute pain. Sixty percent of respondents completed additional training in safe opioid prescribing, yet less than half of respondents (42.86%) felt they could help to mitigate the opioid crisis by prescribing fewer opioids in the emergency department. Conclusion: Emergency physicians frequently prescribe opioids for the treatment of acute pain and new evidence suggests that this practice can lead to significant morbidity. While further research is needed to better understand emergency physicians’ opioid prescribing practices, our findings support the need for evidence-based guidelines for the treatment of acute pain to ensure patient safety.


2015 ◽  
Vol 11 (1) ◽  
pp. 19-30
Author(s):  
Gunvor Hilde ◽  
Kari Bo

Pregnancy and especially vaginal childbirth are risk factors for pelvic floor dysfunctions such as urinary incontinence (UI). The aim of this literature review was to give an overview of how the pelvic floor may be affected by pregnancy and childbirth, and further state the current evidence on pelvic floor muscle training (PFMT) on UI. Connective tissue, peripheral nerves and muscular structures are already during pregnancy subjected to hormonal, anatomical and morphological changes. During vaginal delivery, the above mentioned structures are forcibly stretched and compressed. This may initiate changed tissue properties, which may contribute to altered pelvic floor function and increased risk of UI. Trained pelvic floor muscles (PFM) may counteract the hormonally mediated increased laxity of the pelvic floor and the increased intra-abdominal pressure during pregnancy. Further, a trained PFM may encompass a greater functional reserve so that childbirth does not cause the sufficient loss of muscle function to develop urinary leakage. Additionally, a trained PFM may recover better after childbirth as the appropriate neuromuscular motor patterns have already been learned. Evidence based guidelines recommend that pregnant women having their first child should be offered supervised PFMT, and likewise for women with persistent UI symptoms after delivery (Grade A recommendations). Conclusion: Several observational studies have demonstrated significantly higher PFM strength in continent women than in women having UI, and further that vaginal delivery weakens the PFM. Current evidence based guidelines state that PFMT can prevent and treat UI, and recommend strength training of the PFM during pregnancy and postpartum.


PEDIATRICS ◽  
2013 ◽  
Vol 131 (Supplement 1) ◽  
pp. S103-S109 ◽  
Author(s):  
Lara W. Johnson ◽  
Janie Robles ◽  
Amanda Hudgins ◽  
Shea Osburn ◽  
Devona Martin ◽  
...  

2019 ◽  
Vol 27 (6) ◽  
pp. 557-562
Author(s):  
Heinrich Weber ◽  
Gaylene Bassett ◽  
Doris Bartl ◽  
Mohd Mohd Yusof ◽  
Sukhwinder Sohal ◽  
...  

2021 ◽  
pp. 1-3
Author(s):  
Nina Kobilica ◽  
Nina Kobilica ◽  
Vojko Flis

Accidental intraarterial injection is a serious condition which can compromise the viability of the limb within hours. There are no evidence based guidelines suggesting the proper treatment protocol and there is no consensus about the ideal treatment for these events. We present a case where a mixture of benzodiazepine pills and street heroin was injected in right femoral artery. Patient arrived in hospital days after event. With intraarterial application of thrombolysis, vasodilators and heparin major amputation was avoided. It seems that in selected cases combined therapy with rtPA lysis and PGE1 intra-arterial infusion may prevent major limb amputation even in delayed presentation of acute leg ischaemia caused by inadvertent injection of drugs of abuse.


Neurotrauma ◽  
2018 ◽  
pp. 123-128
Author(s):  
Zandra Olivecrona ◽  
Johan Undén

The Scandinavian Neurotrauma Committee (SNC) was initiated by the Scandinavian Neurosurgical Society to improve the care of neurotrauma patients. The SNC has presented evidence-based guidelines for initial management of minimal, mild, and moderate head injuries. Separate guidelines are presented for children and adults. The biomarker S100β‎ is included in the adult guidelines in an attempt to reduce computed tomography (CT) usage and costs. The aim of the guidelines is to guide physicians in the emergency department during initial management of adult and pediatric patients with minimal, mild, and moderate head injuries, specifically to decide which patients are to receive CT scanning, admission, or discharge from the emergency department.


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