Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel

Allergy ◽  
2002 ◽  
Vol 57 (4) ◽  
pp. 362-365 ◽  
Author(s):  
I. Dalal ◽  
I. Binson ◽  
R. Reifen ◽  
Z. Amitai ◽  
T. Shohat ◽  
...  
Keyword(s):  
Food Allergy ◽  
Young Children ◽  
Allergic Reactions ◽  
Ige Mediated ◽  
Infants And Young Children

scholarly journals Personalized Nutrition Approach in Food Allergy: Is It Prime Time Yet?

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 359 ◽  
Author(s):  
Enza D’Auria ◽  
Mariette Abrahams ◽  
GianVincenzo Zuccotti ◽  
Carina Venter
Keyword(s):  
Food Allergy ◽  
Dietary Intervention ◽  
Unmet Needs ◽  
Tolerance Induction ◽  
Nutritional Recommendations ◽  
Treatment Principle ◽  
Ige Mediated ◽  
Diagnostic Modalities ◽  
Personalized Approach ◽  
Infants And Young Children

The prevalence of food allergy appears to be steadily increasing in infants and young children. One of the major challenges of modern clinical nutrition is the implementation of individualized nutritional recommendations. The management of food allergy (FA) has seen major changes in recent years. While strict allergen avoidance is still the key treatment principle, it is increasingly clear that the avoidance diet should be tailored according to the patient FA phenotype. Furthermore, new insights into the gut microbiome and immune system explain the rising interest in tolerance induction and immunomodulation by microbiota-targeted dietary intervention. This review article focuses on the nutritional management of IgE mediated food allergy, mainly focusing on different aspects of the avoidance diet. A personalized approach to managing the food allergic individual is becoming more feasible as we are learning more about diagnostic modalities and allergic phenotypes. However, some unmet needs should be addressed to fully attain this goal.

scholarly journals Allergic reactions to emerging food allergens in Canadian children

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Lianne Soller ◽  
Sebastien La Vieille ◽  
Scott B. Cameron ◽  
Raymond Mak ◽  
Victoria E. Cook ◽  
...  
Keyword(s):  
Food Allergy ◽  
Allergic Reactions ◽  
Food Allergens ◽  
The Past ◽  
Ige Mediated ◽  
Packaged Foods ◽  
Reaction Severity ◽  
Seeds And Fruits

AbstractMost Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and categorized/confirmed by allergists. A secondary aim was to describe severity of allergic reactions to emerging allergens. Parents reported allergic reactions to emerging food allergens experienced by their child (< 18 years) which occurred in the past 12 months, and allergists categorized/confirmed them according to likelihood of IgE-mediated food allergy. Of 68 eligible patients completing the survey, the most commonly reported emerging allergens were fruits/vegetables (58.8%), seeds (22.1%), legumes (19.1%) and other (11.8%). Median allergist ranking for legumes was ‘probable’ IgE-mediated food allergy, ‘possible’ for seeds and fruits/vegetables, and ‘unlikely’ for other. Median reaction severity was mild for legumes, and moderate for seeds, fruits/vegetables, and other. Our study highlights that non-priority food allergens, namely legumes and seeds, can lead to probable/likely allergic reactions in Canadian children. These food allergens are increasing in popularity in the Canadian diet, which could lead to increasing reports of allergic reactions. More research is needed to confirm reports of reactions to emerging allergens, and to document their inclusion as ingredients in packaged foods.

scholarly journals Clinical manifestations of immunoglobulin E‐mediated food allergy, including pollen‐food allergy syndrome

2020 ◽  
Vol 2 (1) ◽  
pp. 22-25
Author(s):  
Pooja Varshney ◽  
Jacqueline A. Pongracic
Keyword(s):  
Food Allergy ◽  
Immunoglobulin E ◽  
Acute Infection ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Physical Exertion ◽  
Allergic Reactions ◽  
Cutaneous Manifestations ◽  
Ige Mediated ◽  
Inflammatory Drugs

Immunoglobulin E-(IgE) mediated food allergy affects people of all ages but does not have a consistent presentation and may result in various manifestations, even for an individual. The onset of symptoms is usually quite rapid, minutes to a few hours after consumption of the allergen, although exceptions exist. Cutaneous and gastrointestinal symptoms are the most common clinical manifestations; however, they are not present in all allergic reactions. Clinicians, particularly those in emergency care settings, need to be aware that the lack of cutaneous manifestations does not exclude the possibility of anaphylaxis. It is extremely unusual for food allergy reactions to present with isolated upper or lower respiratory symptoms, nor is chronic urticaria a manifestation of food allergy. Clinical manifestations of IgE-mediated food allergy range from mild to severe and, in rare cases, can be fatal. Mild, localized reactions, such as those that occur in pollen‐food allergy syndrome, occur in individuals with sensitization to pollens. A small proportion of patients with this syndrome develop anaphylaxis. Alcohol, medications (nonsteroidal anti-inflammatory drugs, antacids), physical exertion, increased body temperature, acute infection, and menstruation are factors that are known to augment the severity of food-induced allergic reactions.

scholarly journals EAACI guideline: preventing the development of food allergy in infants and young children (2020 update)

2021 ◽  
Author(s):  
Susanne Halken ◽  
Antonella Muraro ◽  
Debra de Silva ◽  
Ekaterina Khaleva ◽  
Elizabeth Angier ◽  
...  
Keyword(s):  
Food Allergy ◽  
Young Children ◽  
Infants And Young Children

scholarly journals Classification and Coding of Data About IgE-mediated Food Allergic Reactions

2020 ◽  
Author(s):  
Chloe French ◽  
Benjamin Green ◽  
Saskia Lawson-Tovey ◽  
Bushra Javed ◽  
Martine Morisset ◽  
...  
Keyword(s):  
Food Allergy ◽  
Signs And Symptoms ◽  
Relevant Information ◽  
Food Allergies ◽  
Allergic Reactions ◽  
Snomed Ct ◽  
Clinical Coding ◽  
Classification Schemes ◽  
Coding Systems ◽  
Ige Mediated

Abstract Background: Collation of clinical data on IgE-mediated food allergies is essential to provide evidenced-based approaches to managing and treating food allergies and prevent accidental reactions. However, this can be a time consuming and difficult process due to the heterogeneous way in which studies collect such data. In order to facilitate data harmonisation a set of standardised terminologies have been identified and a consensus technique established to code food allergy data.Methods: Different terminologies to encode the most common signs, symptoms and problematic foods associated with IgE-mediated food allergies were identified. Their suitability for classifying and coding information about the signs and symptoms of food allergic reactions, causative foods and reaction severity of was assessed. The assessment included existing conceptual coverage and data descriptions, classification schemes and additional relevant information.Results: All of the terminologies reviewed included classification schemes, allowing broader concepts to be related to those that are more specialised. Additional information was often present such as equivalence. Of the clinical coding systems assessed, the Systemized Nomenclature of Medical Clinical Terms (SNOMED-CT) provided the most complete coverage with options to code symptom severity. Only food coding systems, such as FoodEx2, provided comprehensive conceptual coverage of the food terms.Conclusions: Utilising SNOMED-CT and FoodEx2 standards together will support the harmonisation of data regarding food allergy from diverse sources, providing a transparent and effective way to collate relevant data required for effective food allergen management in the future.

scholarly journals Developing food allergy: a potential immunologic pathway linking skin barrier to gut

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2660 ◽  
Author(s):  
Yui-Hsi Wang
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Immunoglobulin E ◽  
Lymphoid Cells ◽  
Th2 Cells ◽  
Allergic Reactions ◽  
Mucosal Mast Cells ◽  
Life Threatening ◽  
Ige Mediated

Immunoglobulin E (IgE)-mediated food allergy is an adverse reaction to foods and is driven by uncontrolled type-2 immune responses. Current knowledge cannot explain why only some individuals among those with food allergy are prone to develop life-threatening anaphylaxis. It is increasingly evident that the immunologic mechanisms involved in developing IgE-mediated food allergy are far more complex than allergic sensitization. Clinical observations suggest that patients who develop severe allergic reactions to food are often sensitized through the skin in early infancy. Environmental insults trigger epidermal thymic stromal lymphopoietin and interleukin-33 (IL-33) production, which endows dendritic cells with the ability to induce CD4+TH2 cell-mediated allergic inflammation. Intestinal IL-25 propagates the allergic immune response by enhancing collaborative interactions between resident type-2 innate lymphoid cells and CD4+TH2 cells expanded by ingested antigens in the gastrointestinal tract. IL-4 signaling provided by CD4+TH2 cells induces emigrated mast cell progenitors to become multi-functional IL-9-producing mucosal mast cells, which then expand greatly after repeated food ingestions. Inflammatory cytokine IL-33 promotes the function and maturation of IL-9-producing mucosal mast cells, which amplify intestinal mastocytosis, resulting in increased clinical reactivity to ingested food allergens. These findings provide the plausible view that the combinatorial signals from atopic status, dietary allergen ingestions, and inflammatory cues may govern the perpetuation of allergic reactions from the skin to the gut and promote susceptibility to life-threatening anaphylaxis. Future in-depth studies of the molecular and cellular factors composing these stepwise pathways may facilitate the discovery of biomarkers and therapeutic targets for diagnosing, preventing, and treating food allergy.

Effect of atopic dermatitis on the natural course of food allergy in infants and young children

2017 ◽  
Vol 5 (5) ◽  
pp. 256 ◽  
Author(s):  
Ji Sun Park ◽  
Soon Jeong Moon ◽  
Dae Hyun Lim ◽  
Hae Ji Jang ◽  
Sun Young Hwang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Young Children ◽  
Natural Course ◽  
Infants And Young Children
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