Reproducible identification of the causative drug of a fixed drug eruption by oral provocation and lesional patch testing

2002 ◽  
Vol 46 (6) ◽  
pp. 352-353 ◽  
Author(s):  
Sven Zedlitz ◽  
Lars Linzbach ◽  
Roland Kaufmann ◽  
Wolf-Henning Boehncke
Keyword(s):  
Patch Testing ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Oral Provocation ◽  
Causative Drug ◽  
Fixed Drug

scholarly journals Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole

2021 ◽  
Author(s):  
Michael Makris ◽  
Christos Fokoloros ◽  
Anna Syrmali ◽  
Zoi Tsakiraki ◽  
Vasileia Damaskou ◽  
...  
Keyword(s):  
Patch Testing ◽  
Drug Eruption ◽  
Adverse Reactions ◽  
Clinical Course ◽  
Fixed Drug Eruption ◽  
Positive Patch Test ◽  
Oral Provocation ◽  
Fixed Drug ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical bullous lesions in previous and new sites after re-administration of the offending drug. We present a well-documented case of fluconazole-induced GBFDE, with a positive patch test to fluconazole (30% weight/volume preparation) and clinical tolerance to itraconazole proven by negative oral provocation. Even in SCARs, patch testing represents a useful diagnostic tool, while oral provocation remains the gold standard in cases that an alternative but the chemically relevant drug must be administered.  

scholarly journals Doxycycline induced fixed drug eruption: a case report

2018 ◽  
Vol 7 (11) ◽  
pp. 2264
Author(s):  
Isswariya Anandan ◽  
Nitya Selvaraj ◽  
Suganya Ganesan ◽  
Meher Ali Rajamohammad ◽  
Nalinidevi Jayabalan
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Drug Eruption ◽  
Skin Lesions ◽  
Severity Assessment ◽  
Fixed Drug Eruption ◽  
Skin Reactions ◽  
Dermatological Examination ◽  
Causative Drug ◽  
Fixed Drug

Fixed drug eruption (FDE) is an adverse drug reaction seen with various groups of drugs are antibiotics such as trimethoprim -sulphamethoxazle, pencillin, tetracyclines, non steroidal anti- inflammatory drugs like ibuprofen, aspirin etc. Doxycycline belongs to tetracycline groups of antibiotics. We herein present the case of Doxycycline induced fixed drug eruption. A 35-year - old man presented to our hospital, with a 2-day history of itching and hyperpigmentation over the chest. Patient developed skin lesion 2 days after and he started taking Doxycycline 100 mg twice a day for skin infections. Dermatological examination revealed multiple well defined hyperpigmented patches seen over the anterior aspect of the chest. Doxycycline was discontinued immediately, and the skin lesions resolved spontaneously within 2 weeks. Causality assessment by using Naranjo adverse drug reaction probability scale and WHO Uppsala monitoring scale categorize the reaction as Doxycycline was the probable cause for the adverse drug reaction. Severity assessment by using modified Hartwig and Siegel ADR severity assessment scale labelled the reaction as mild-level 2. The causative drug or drugs and cross reactants should be avoided in future to prevent recurrence of similar skin reactions.

Acebrophylline-induced generalized fixed drug eruption confirmed by an oral provocation test

2017 ◽  
Vol 5 (5) ◽  
pp. 298
Author(s):  
Su Jin Jeong ◽  
Heon Sa-Kong ◽  
Dong-Hee Park ◽  
Sung Geun Lee ◽  
So Young Jung ◽  
...  
Keyword(s):  
Drug Eruption ◽  
Provocation Test ◽  
Fixed Drug Eruption ◽  
Oral Provocation ◽  
Fixed Drug ◽  
Oral Provocation Test

scholarly journals Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014)

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hossein Kavoussi ◽  
Mansour Rezaei ◽  
Katayoun Derakhshandeh ◽  
Alireza Moradi ◽  
Ali Ebrahimi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Drug Eruption ◽  
Cross Sectional Study ◽  
Fixed Drug Eruption ◽  
The West ◽  
Cross Sectional ◽  
Drug Eruptions ◽  
Causative Drug ◽  
Fixed Drug ◽  
Antibiotic Group

Background.Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran.Method.This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected.Results.Out of 30 patients (17 females and 13 males) with the mean age of26.67±10.21years, 28 (93.3%) and 2 (6.7%) cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common (90%) site of involvement. The antibiotic group, especially cotrimoxazole (26.1%), was reported to be the most common offending drug, but the causative drug was not determined in 7 (23.3%) patients.Conclusion.Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test.

scholarly journals Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing

2018 ◽  
Vol 93 (3) ◽  
pp. 470-472 ◽  
Author(s):  
Lidiane Pereira Marques ◽  
Ana Luiza Castro Fernandes Villarinho ◽  
Maria das Graças Mota Melo ◽  
Marília Gabriela Senra Torre
Keyword(s):  
Patch Testing ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug

scholarly journals Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

2022 ◽  
pp. 6-11
Author(s):  
Risa Shimizu ◽  
Fumihiko Tsushima ◽  
Ruri Komiya ◽  
Yuko Yamagata ◽  
Hiroyuki Harada
Keyword(s):  
Drug Eruption ◽  
Repeated Administration ◽  
Menstrual Pain ◽  
Fixed Drug Eruption ◽  
Causative Drug ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Simplex Virus ◽  
Rule Out

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

Bullous fixed drug eruption induced by fluconazole: Importance of multi‐site lesional patch testing

2020 ◽  
Author(s):  
Ky Lyn Tan ◽  
Ilaria Bisconti ◽  
Claire Leck ◽  
Thippeswamy Billahalli ◽  
Sheena Barnett ◽  
...  
Keyword(s):  
Patch Testing ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug
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