Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

2005 ◽  
Author(s):  
Carol A. Manning
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Elderly People ◽  
Randomized Study

Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life

2006 ◽  
Vol 21 (8) ◽  
pp. 1119-1122 ◽  
Author(s):  
Angelo Antonini ◽  
Silvana Tesei ◽  
Anna Zecchinelli ◽  
Paolo Barone ◽  
Danilo De Gaspari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Low Dose ◽  
Randomized Study ◽  
Depression Effect

scholarly journals Unawareness of Hyposmia in Elderly People With and Without Parkinson's Disease

2015 ◽  
Vol 3 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Holly A. Shill ◽  
Joseph G. Hentz ◽  
John N. Caviness ◽  
Erika Driver-Dunckley ◽  
Sandra Jacobson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Elderly People

scholarly journals Continuous Subcutaneous Levodopa Delivery for Parkinson’s Disease: A Randomized Study

2020 ◽  
pp. 1-10
Author(s):  
C. Warren Olanow ◽  
Alberto J. Espay ◽  
Fabrizio Stocchi ◽  
Aaron L. Ellenbogen ◽  
Mika Leinonen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study ◽  
Preliminary Evidence ◽  
Common Adverse Event ◽  
Open Label ◽  
Open Label Study ◽  
Dosing Regimens ◽  
Optimized Treatment ◽  
Off Time

Background: ND0612 is a continuous, subcutaneous levodopa/carbidopa delivery system in development for patients with Parkinson’s disease (PD) experiencing motor fluctuations Objective: Evaluate the efficacy and safety of two ND0612 dosing regimens in patients with PD. Methods: This was a 28-day open-label study (NCT02577523) in PD patients with ≥2.5 hours/day of OFF time despite optimized treatment. Patients were randomized to treatment with either a 24-hour infusion (levodopa/carbidopa dose of 720/90 mg) or a 14-hour ‘waking-day’ infusion (levodopa/carbidopa dose of 538/68 mg plus a morning oral dose of 150/15 mg). In-clinic assessments of OFF time (primary endpoint) and ON time with or without dyskinesia were determined by a blinded rater over 8 hours (normalized to 16 hours). Results: A total of 38 patients were randomized and 33 (87% ) completed the study. Compared to baseline, OFF time for the overall population was reduced by a least squares (LS) mean[95% CI] of 2.0[– 3.3, – 0.7] hours (p = 0.003). ON time with no/mild dyskinesia was increased from baseline by a LS mean of 3.3[2.0, 4.6] hours (p <  0.0001), and ON time with moderate/severe dyskinesia was reduced by a LS mean of 1.2[– 1.8, – 0.5] hours (p≤0.001). Reduction in OFF time was larger in the 24-hour group (– 2.8[– 4.6, – 0.9] hours; p = 0.004) than in the 14-hour group (– 1.3[– 3.1, 0.5] hours; p = 0.16). Complete resolution of OFF time was observed in 42% (n = 8) of patients in the 24-hour group. Infusion site reactions were the most common adverse event. Conclusion: This study demonstrates the feasibility and safety of continuous subcutaneous delivery of levodopa as a treatment for PD and provides preliminary evidence of efficacy.

scholarly journals Antidepressants for Depression, Apathy, and Gait Instability in Parkinson's Disease: A Multicenter Randomized Study

2019 ◽  
Vol 58 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Makio Takahashi ◽  
Hayato Tabu ◽  
Akihiko Ozaki ◽  
Toshiaki Hamano ◽  
Takao Takeshima ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study

scholarly journals Rasagiline monotherapy in early Parkinson's disease: A phase 3, randomized study in Japan

2019 ◽  
Vol 60 ◽  
pp. 146-152 ◽  
Author(s):  
Nobutaka Hattori ◽  
Atsushi Takeda ◽  
Shinichi Takeda ◽  
Akira Nishimura ◽  
Tadayuki Kitagawa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study ◽  
Phase 3 ◽  
Early Parkinson’S Disease

scholarly journals DETERMINING FACTORS IN THE SITUATIONAL TRANSITION OF FAMILY MEMBERS WHO CARE OF ELDERLY PEOPLE WITH PARKINSON'S DISEASE

2019 ◽  
Vol 28 ◽  
Author(s):  
Simony Fabíola Lopes Nunes ◽  
Angela Maria Alvarez ◽  
Maria Fernanda Baeta Neves Alonso da Costa ◽  
Rafaela Vivian Valcarenghi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Health Services ◽  
Physical Health ◽  
Family Support ◽  
Elderly People ◽  
Advanced Age ◽  
The Family ◽  
Elderly Caregivers

ABSTRACT Objective: to investigate the facilitator and inhibitory factors in the transition of elderly caregivers with Parkinson's disease. Method: a qualitative, exploratory and descriptive study, based on the family transition nursing theory developed with 20 elderly caregivers of elderly people with Parkinson 's disease, enrolled in the Associação Parkinson de Santa Catarina, from March to August 2015. To analyze and interpret the data, we used the thematic analysis of content proposed by Bardin, with the help of the ATLAS.ti software for data organization. Results: some factors were identified and considered as facilitators for the process of transition from the familiar to the exercise of the role of caregiver, such as: previous experiences as caregiver; spirituality and religiosity; family support network and health services. Other factors were identified as inhibiting factors for transition: emotional and physical health conditions; advanced age; personal life activities/commitments; family financial burden; and inadequate family support. It was observed that most family caregivers reported having previous experience in caring, having advanced age, and being able to care for the elderly with the disease. However, he considers his condition of emotional and physical health insufficient, resulting in overload. Lack of access to health services and family and financial support make it difficult to provide care. Conclusion: nurses should seek strategies to direct attention to facilitating factors in the family context in order to help the family to achieve well-being and healthy transition to the role of caregiver.

scholarly journals Levodopa and executive performance in Parkinson's disease: A randomized study

2008 ◽  
Vol 14 (5) ◽  
pp. 832-841 ◽  
Author(s):  
BERTA PASCUAL-SEDANO ◽  
JAIME KULISEVSKY ◽  
MANEL BARBANOJ ◽  
CARMEN GARCÍA-SÁNCHEZ ◽  
ANTONIA CAMPOLONGO ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peak Plasma ◽  
Peak Plasma Concentration ◽  
Randomized Study ◽  
Plasma Concentrations ◽  
Wisconsin Card Sorting Test ◽  
Cognitive Changes ◽  
Executive Performance ◽  
Tower Of Hanoi

Parkinson's disease (PD) patients may experience fluctuations in executive performance after oral levodopa (LD). Their relationship with the pharmacokinetic profile of LD and with distinct cognitive processes associated with frontal-basal ganglia circuits is not well understood. In this randomized, double-blind, crossover study we plotted acute cognitive changes in 14 PD patients challenged with faster (immediate-release, IR) versus slower (controlled-release, CR) increases in LD plasma concentrations. We monitored motor status, LD plasma levels, and performance on four tasks of executive function (Wisconsin Card Sorting Test—WCST, Sternberg test, Stroop and Tower of Hanoi), 1 hr before and over +6 hr after IR and CR-LD dose. Analysis of variance demonstrated significant but divergent changes in the Sternberg (6-digit but not 2- and 4-digit) test: improvement after CR-LD and worsening after IR-LD. Marginal improvement (p = .085) was observed with CR-LD in the WCST, while no significant differences were seen for the Stroop or Tower of Hanoi tests. Executive-related performance after LD challenge may differ depending on the LD time-to-peak plasma concentration and specific task demands. A slower rise in LD levels appears to have a more favorable impact on more difficult working memory tests. These results require replication to determine their generalization. (JINS, 2008, 14, 832–841.)

Amplitude-oriented exercise in Parkinson’s disease: a randomized study comparing LSVT-BIG and a short training protocol

2014 ◽  
Vol 122 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Georg Ebersbach ◽  
Ute Grust ◽  
Almut Ebersbach ◽  
Brigitte Wegner ◽  
Florin Gandor ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study ◽  
Training Protocol

scholarly journals Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study

2020 ◽  
Vol 78 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Ana Cristina TILLMANN ◽  
Alessandra SWAROWSKY ◽  
Clynton Lourenço CORRÊA ◽  
Alexandro ANDRADE ◽  
Jéssica MORATELLI ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study ◽  
General Information ◽  
Control Group ◽  
Action Strategies ◽  
And Control ◽  
Experimental Group

Abstract Background: New protocols applied in the rehabilitation of Parkinson's disease enable different action strategies for health professionals, as well as a new range of activities for these individuals. However, no valid samba protocol with activity prescription for this population was found in the literature. Objective: To investigate the feasibility of a Brazilian samba protocol in individuals with Parkinson's disease. Methods: Twenty participants, mean age of 66.4±10.7 years, diagnosed with idiopathic Parkinson 's disease, divided into: experimental group that received the intervention of Brazilian samba dance classes (10 individuals); and control group that maintained their routine activities (10 individuals). For data collection, a divided questionnaire was used: General Information; Disability stages scale; Balance and Quality of Life. Results: During class implementation, there were no falls, as all dance activities adhered to the details of the protocol steps without any changes. On average, patients completed 82.7% of activities. After 12 weeks, the experimental group had improvements in the UPDRS global score, in daily activities, and on motor examination. There was also improvement in balance scores and in the mobility domain of the quality of life in the experimental group. Conclusion: The samba protocol seems to be feasible and safe for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.

scholarly journals Brazilian Samba Protocol for Individuals With Parkinson’s Disease: A Clinical Non-Randomized Study

2017 ◽  
Vol 6 (7) ◽  
pp. e129 ◽  
Author(s):  
Ana Cristina Tillmann ◽  
Alexandro Andrade ◽  
Alessandra Swarowsky ◽  
Adriana Coutinho De Azevedo Guimarães
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study
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