Abstract::
Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic
values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine
practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices
based on these has its pros and cons and has been greatly affected during the dawn. The search of new drugs during scientific
era revives the interest in discovery of herbal drugs from different natural resources during 20th century. The present
modern healthcare system invovlves utilization drugs and 50% of them are of ofnaural origin. Herbal drug disocovery found
to be highly costly affair with low success rate and it hinders the further progress in utilizting the phytomedicine in treating
the various deseases. But in recent years there is an increase in the search interest of herbal drugs mainly by the pharmaceutical
industry and those invoves in the search of novel drugs from the herbs. Discovery of such new novel phytomedicines
has to overcomes various challenges in indentification of active extracts and their toxicity, advereffects, herb drug interaction
and importantly their regulatory requirments. The present review mainly focused on the history of herbal medicine,
current clinical perspective, pharmaceutical, and regulatory challenges as well as its clinical presentation. Moreover, problems
encountered in drug discovery from herbal resources and its possible solutions are delineated.
306 - Loneliness and mortality in older adults and the role of depression
