Herbal Medicine: Clinical Perspective & Regulatory Status

2020 ◽  
Vol 23 ◽  
Author(s):  
Md Abul Barkat ◽  
Anjali Goyal ◽  
Harshita Abul Barkat ◽  
Mohammad Salauddin ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
New Drugs ◽  
Herbal Drugs ◽  
Clinical Perspective ◽  
Regulatory Status ◽  
Novel Drugs ◽  
History Of ◽  
Pros And Cons ◽  
Health Complications

Abstract:: Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices based on these has its pros and cons and has been greatly affected during the dawn. The search of new drugs during scientific era revives the interest in discovery of herbal drugs from different natural resources during 20th century. The present modern healthcare system invovlves utilization drugs and 50% of them are of ofnaural origin. Herbal drug disocovery found to be highly costly affair with low success rate and it hinders the further progress in utilizting the phytomedicine in treating the various deseases. But in recent years there is an increase in the search interest of herbal drugs mainly by the pharmaceutical industry and those invoves in the search of novel drugs from the herbs. Discovery of such new novel phytomedicines has to overcomes various challenges in indentification of active extracts and their toxicity, advereffects, herb drug interaction and importantly their regulatory requirments. The present review mainly focused on the history of herbal medicine, current clinical perspective, pharmaceutical, and regulatory challenges as well as its clinical presentation. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are delineated.

Nano Phytomedicine Based Delivery System for CNS Disease

2020 ◽  
Vol 21 (9) ◽  
pp. 661-673 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Chettupalli Anand ◽  
Abdul Muheem ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Low Cost ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Widespread Acceptance ◽  
The Central Nervous System ◽  
Low Toxicity ◽  
Ancient Times ◽  
Plant Sources ◽  
Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

scholarly journals Rare Treatments for Rare Dyslipidemias: New Perspectives in the Treatment of Homozygous Familial Hypercholesterolemia (HoFH) and Familial Chylomicronemia Syndrome (FCS)

2021 ◽  
Vol 23 (11) ◽  
Author(s):  
Laura D’Erasmo ◽  
Simone Bini ◽  
Marcello Arca
Keyword(s):  
Familial Hypercholesterolemia ◽  
Treatment Options ◽  
New Drugs ◽  
Lipid Lowering ◽  
Homozygous Familial Hypercholesterolemia ◽  
Published Evidence ◽  
Novel Drugs ◽  
Life Threatening ◽  
History Of ◽  
Definition Of

Abstract Purpose of Review This review aims to summarize the most recent published literature concerning lomitapide and volanesorsen that are approved for the use in HoFH and FCS patients, respectively. Moreover, it will briefly revise the published evidence on novel, non-approved treatments that are under evaluation for the management of these rare forms of dyslipidemias Recent Findings The definition of rare dyslipidemias identifies a large number of severe disorders of lipid metabolism of genetic origin. Among them were homozygous familial hypercholesterolemia (HoFH) (OMIM #143890) and familial chylomicronemia syndrome (FCS) (OMIM #238600), which are characterized by a markedly impaired cholesterol- and triglyceride-containing lipoproteins metabolism. They are being particularly associated with poor health outcomes and quality of life. Considering the severity of these diseases, common lipid-lowering drugs are often ineffective or do not allow to achieve the recommended lipid targets to prevent the development of complications. Nowadays, several new drugs have been found to effectively treat HoFH and FCS with an acceptable safety profile. Summary Treating patients with HoFH and FCS remains very challenging. However, novel treatment options are emerging and might be considered in addition to conventional therapy for managing these diseases. These novel drugs will possibly change the natural history of these two rare and life-threatening diseases.

scholarly journals Safety of Herbal Medicines in Children

2021 ◽  
Author(s):  
Sevinç Polat ◽  
Ayşe Gürol
Keyword(s):  
Herbal Medicine ◽  
Pediatric Population ◽  
Clinical Care ◽  
Herbal Medicines ◽  
World Health ◽  
Herbal Products ◽  
Medicines Use ◽  
Herbal Medicinal ◽  
Health Complications ◽  
Health Organization

Herbal medicine is used by individuals of all ages, including children. Herbal medicine includes herbs, herbal materials and preparations, and finished herbal products. Herbal medicine or herbal products’ use for all ages have increased in recent years. Based on the data of the World Health Organization, almost 80% of the population in developing countries trust herbal medicines to meet their health needs. Herbal medicines use unconsciously as though these products are harmless. The use of herbal products in children is a concern because little information is available concerning the benefits and risks of these products in the pediatric population. This creates a serious problem in the treatment of children, and reveals a serious and under-recognized hazard in clinical care. The safety of most herbal medicinal products is absent since lack of suitable quality controls and not available of appropriate patient information. Owing to the possibility of serious health complications arising from the use of herbal products, it is mandatory to understand their use in the general population in order for appropriate measures to be put into place.

Herbal medicine: current progress, and challenges

2019 ◽  
Vol 15 ◽  
Author(s):  
Abul Barkat ◽  
Anjali Goyal ◽  
Abul Harshita ◽  
Faheem Hyder Pottoo ◽  
Sarwar Beg ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Capital Investment ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
New Drugs ◽  
Disease Treatment ◽  
Late 20Th Century ◽  
Regulatory Standards ◽  
Medicine History ◽  
Regulatory Challenges

: Phytomedicine or herbal medicines have played an important role in disease treatment because of high therapeutic potential and better patient compliance. Although the practice of phytomedicne greatly affected during the dawn of the scientific era, there is a revival of interest in its potential by late 20th century, especially in the search of new drugs. Herbal drugs and its derivatives represent more than 50% of entire drugs in modern healthcare system. Because of the low success rate and huge capital investment hinders the further application of phytomedicine in disease treatment. In recent time, an increase of interest in the herbal meidicine has been observed by pharmaceutical industry to search novel phytotherapeutics. In the search of new phytomedicine there are several challenges identified like-the reproducibility of pharmacological activity of herbal extracts, toxicity and adverse effects, adulteration and contamination, herb–drug interactions issues; poor scientific and regulatory standards. In this review, we illustrated a short overview on herbal medicine history, current clinical perspective, pharmaceutical and regulatory challenges as well as its clinical presence. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are described.

scholarly journals Effects of alkaloids on peripheral neuropathic pain: a review

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Chunhao Zhu ◽  
Ning Liu ◽  
Miaomiao Tian ◽  
Lin Ma ◽  
Jiamei Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Molecular Mechanisms ◽  
Herbal Medicines ◽  
New Drugs ◽  
Intractable Pain ◽  
Chinese Herbal Medicines ◽  
Peripheral Neuropathic Pain ◽  
Chinese Herbal ◽  
Toxicological Studies ◽  
Novel Drugs

Abstract Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects. Therefore, it is necessary to investigate alternative medicines for neuropathic pain. Chinese herbal medicines have been widely used in treating intractable pain. Compelling evidence revealed that the bioactive alkaloids of Chinese herbal medicines stand out in developing novel drugs for neuropathic pain due to multiple targets and satisfactory efficacy. In this review, we summarize the recent progress in the research of analgesic effects of 20 alkaloids components for peripheral neuropathic pain and highlight the potential underlying molecular mechanisms. We also point out the opportunities and challenges of the current studies and shed light on further in-depth pharmacological and toxicological studies of these bioactive alkaloids. In conclusion, the alkaloids hold broad prospects and have the potentials to be novel drugs for treating neuropathic pain. This review provides a theoretical basis for further applying some alkaloids in clinical trials and developing new drugs of neuropathic pain.

scholarly journals Herbal medicine: from the past to the future

2000 ◽  
Vol 3 (4a) ◽  
pp. 447-452 ◽  
Author(s):  
Varro E Tyler
Keyword(s):  
United States ◽  
Herbal Medicine ◽  
Herbal Medicines ◽  
The United States ◽  
Regulatory Environment ◽  
American People ◽  
The Past ◽  
Mainstream Medicine ◽  
History Of ◽  
Education Act

AbstractA brief discussion of the history of the use of herbal medicines from prehistoric times to the mid-twentieth century precedes an explanation of why usage of such remedies in the United States declined in the 1940s but returned to popularity in the 1980s. The provisions of the Dietary Supplement Health and Education Act of 1994 are presented together with its perceived influence, both positive and negative, on the health of the American people. Possible futures of herbal medicines are considered. The negative viewpoint that they will ultimately be rejected is refuted, and the more optimistic prediction that herbs are ultimately destined to become a part of mainstream medicine is defended. Stumbling blocks to such acceptance are evaluated and methods of overcoming them suggested. The urgent need for the development of a sensible regulatory environment encouraging the approval of botanicals as drugs is emphasized. After predicting a bright future for rational phytomedicines, the author opines that many of them will eventually play significant roles in medicinal practice.

Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis

2020 ◽  
Author(s):  
Morteza Anvari ◽  
Hengameh Dortaj ◽  
Batool Hashemibeni ◽  
Majid Pourentezari
Keyword(s):  
Rheumatoid Arthritis ◽  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Herbal Medicine ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Low Back ◽  
Herbal Drugs ◽  
Efficacy And Safety

Rheumatic diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), and low back pain are very popular. The drugs available to treat these diseases are almost ineffective and have significant side effects. There are several approaches used to replace conventional drugs to treat these diseases. One of these methods is the use of herbal medicines. In this study, the effects of herbal medicines and medicinal plants used in the treatment of these diseases include. Searching for articles published in English from 1985 to 2020 using keywords include scientific and traditional names of plants reviewing Scopus and PubMed databases. There is limited research on the anti-rheumatic effects of these plants and the active ingredients. Therefore, further research is needed to determine the mechanism of action, the interaction of effects, the efficacy and safety of medicinal plants, and the potentially beneficial plant nutrients in treatment of these diseases seems necessary. The aim of this review was to update information on OA and chondrogenesis, also importance of herbal drugs for the management of arthritis.

scholarly journals Saraswati Panchak – A Novel Herbal Combination for Mental Health

2021 ◽  
Vol 3 (2) ◽  
pp. 09-18
Author(s):  
Ruchi Singh
Keyword(s):  
Mental Health ◽  
Quality Control ◽  
Chemical Constituents ◽  
Herbal Medicines ◽  
Complete Analysis ◽  
Herbal Drugs ◽  
Active Constituent ◽  
Coarse Powder ◽  
Physico Chemical ◽  
History Of

Herbal medicines have a history of long therapeutic use and are still serving a lot of the health needs of a big population of the world. However, the quality control still remains a challenge because of the variation of chemical constituents involved. There are numerous compounds in herbal drugs that are in complex matrices in which no single active constituent is responsible for the overall efficacy. This creates a challenge in establishing quality control standards and standardization of finished herbal drugs. Saraswati Panchak is a novel combination given by Pandit Shri Ram Sharma Acharya for mental health. In this study, components of this novel herbal combination were explained for its potential utility in mental illness. In addition, the study also detailed how Saraswati Panchak Churna was converted into tablet form to increase the shelf life, make it easy to dispense, for dose fixation, etc. The tablet was subjected to organoleptic analysis and physico-chemical analysis to establish its efficacy. After performing complete analysis it was found that all the parameters are within the range. The coarse powder of these herbs may be used as havan samagri in brain related disorders because of the presence of nootropic herbs.

Musikalisasi Syi’ir Aqoid Kiai Zaini Mun’im dan Budidaya Tanaman Obat Keluarga (Toga) di Pesantren Nurul Jadid Probolinggo

2020 ◽  
Vol 1 (1) ◽  
pp. 47-58
Author(s):  
Khodijatul Qodriyah
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
Successful Implementation ◽  
Short Term ◽  
Middle Term

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman

Novel Drugs and Biologics of 2016: A Boom for Neurodrugs in the Pipelin

2017 ◽  
Vol 10 (5) ◽  
pp. 3809-3814
Author(s):  
D Samba Reddy
Keyword(s):  
Muscular Atrophy ◽  
Clinical Care ◽  
New Drugs ◽  
Essential Medicines ◽  
High Demand ◽  
The Past ◽  
Novel Drugs ◽  
Innovative Products ◽  
Cns Drugs ◽  
The U.S

This article provides a brief overview of novel drugs approved by the U.S. FDA in 2016.  It also focuses on the emerging boom in the development of neurodrugs for central nervous system (CNS) disorders. These new drugs are innovative products that often help advance clinical care worldwide, and in 2016, twenty-two such drugs were approved by the FDA. The list includes the first new drug for disorders such as spinal muscular atrophy, Duchenne muscular dystrophy or hallucinations and delusions of Parkinson’s disease, among several others. Notably, nine of twenty-two (40%) were novel CNS drugs, indicating the industry shifting to neurodrugs. Neurodrugs are the top selling pharmaceuticals worldwide, especially in America and Europe. Therapeutic neurodrugs have proven their significance many times in the past few decades, and the CNS drug portfolio represents some of the most valuable agents in the current pipeline. Many neuroproducts are vital or essential medicines in the current therapeutic armamentarium, including dozens of “blockbuster drugs” (drugs with $1 billion sales potential).  These drugs include antidepressants, antimigraine medications, and anti-epilepsy medications. The rise in neurodrugs’ sales is predominantly due to increased diagnoses of CNS conditions. The boom for neuromedicines is evident from the recent rise in investment, production, and introduction of new CNS drugs.  There are many promising neurodrugs still in the pipeline, which are developed based on the validated “mechanism-based” strategy. Overall, disease-modifying neurodrugs that can prevent or cure serious diseases, such as multiple sclerosis, epilepsy, and Alzheimer’s disease, are in high demand. 

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