Glucose-6-Phosphate Dehydrogenase Deficiency in Red Blood Cells of East Africans

Nature ◽  
1960 ◽  
Vol 186 (4724) ◽  
pp. 531-532 ◽  
Author(s):  
A. C. ALLISON
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Dehydrogenase Deficiency ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Sulfhemoglobinemia and Acute Hemolytic Anemia with Heinz Bodies Following Contact with a Fungicide— Zinc Ethylene Bisdithiocarbamate—in a Subject with Glucose-6-Phosphate Dehydrogenase Deficiency and Hypocatalasemia

Blood ◽  
1963 ◽  
Vol 21 (4) ◽  
pp. 484-494 ◽  
Author(s):  
JACK PINKHAS ◽  
MEIR DJALDETTI ◽  
HENRY JOSHUA ◽  
CHAIM RESNICK ◽  
ANDRÉ DE VRIES
Keyword(s):  
Red Blood Cells ◽  
Hemolytic Anemia ◽  
Blood Cells ◽  
Dehydrogenase Deficiency ◽  
Reduced Glutathione ◽  
Body Formation ◽  
Low Glucose ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Enzymatic Defect

Abstract Sulfhemoglobinemia associated with Heinz body formation and acute hemolytic anemia following contact with a fungicide, zinc ethylene bisdithiocarbamate, is described in a Persian Jew whose red blood cells had low glucose-6-phosphate dehydrogenase activity with low and unstable reduced glutathione and low catalase activity. The fungicide, similarly to acetylphenylhydrazine, was capable of decreasing in vitro the reduced glutathione of the patient’s red blood cells, as well as of those of other subjects with the same enzymatic defect. The sulfhemoglobinemia and the hemolytic anemia are considered to have been produced independently by the fungicide, the glucose-6-phosphate dehydrogenase deficiency having played a role only in the latter. The possibility that the hypocatalasemia was a factor in rendering the patient’s red blood cells sensitive to the hemolysis- and sulfhemoglobin-producing action of the fungicide is discussed. The importance of zinc ethylene bisdithiocarbamate as a sulfhemoglobin-producing and hemolytic agent is stressed, in view of the widespread use of this fungicide.

Glucose-6-phosphate dehydrogenase deficiency and cardiac surgery

Perfusion ◽  
2010 ◽  
Vol 25 (6) ◽  
pp. 417-421 ◽  
Author(s):  
N. Dogra ◽  
GD Puri ◽  
SS Rana
Keyword(s):  
Cardiac Surgery ◽  
Blood Cells ◽  
Perioperative Management ◽  
Dehydrogenase Deficiency ◽  
Ischemia Reperfusion ◽  
Anaesthetic Management ◽  
Whole Body ◽  
Free Radical Production ◽  
Radical Production ◽  
Glucose 6 Phosphate Dehydrogenase

Cardiac surgery involving cardiopulmonary bypass (CPB) in its conventional form involves many processes leading to free radical production, such as perioperative ischemia, reperfusion, circulation of whole body blood through the CPB circuit, hypothermia and acidosis. The red blood cells of a glucose-6-phosphate dehydrogenase (G6PD)-deficient person are unable to scavenge these free radicals, resulting in haemolysis. Here, we describe the successful anaesthetic management of two G6PD-deficient children who underwent cardiac surgery, on and off CPB, without any obvious haemolytic reaction, followed by a discussion of the disorder, with specific consideration of perioperative management of such cases.

scholarly journals The Course of Experimentally Induced Hemolytic Anemia in a Primaquine-Sensitive Caucasian

Blood ◽  
1965 ◽  
Vol 25 (1) ◽  
pp. 92-95 ◽  
Author(s):  
IVO PANNACCIULLI ◽  
ALBERTO TIZIANELLO ◽  
FRANCO AJMAR ◽  
EMANUELE SALVIDIO
Keyword(s):  
Red Blood Cells ◽  
Hemolytic Anemia ◽  
Blood Cells ◽  
Drug Induced ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Experimentally Induced

Abstract Two severe hemolytic crises, in a month’s period, were induced by primaquine in a glucose-6-phosphate dehydrogenase deficient Sardinian male. Young red blood cells tagged with Fe59 10 to 16 days earlier were destroyed in the second hemolytic episode. The implications of these experiments on the nature of drug-induced hemolysis in Caucasians are briefly discussed.

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