scholarly journals Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity

2014 ◽  
Vol 5 (12) ◽  
pp. e1568-e1568 ◽  
Author(s):  
C Göbel ◽  
F Breitenbuecher ◽  
H Kalkavan ◽  
P S Hähnel ◽  
S Kasper ◽  
...  
Keyword(s):  
Functional Expression ◽  
Expression Cloning ◽  
Cancer Immunity ◽  
Specific Cancer ◽  
Cox 2

scholarly journals ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

Nature ◽  
2020 ◽  
Vol 579 (7797) ◽  
pp. 130-135 ◽  
Author(s):  
John Alec Moral ◽  
Joanne Leung ◽  
Luis A. Rojas ◽  
Jennifer Ruan ◽  
Julia Zhao ◽  
...  
Keyword(s):  
Tissue Specific ◽  
Cancer Immunity ◽  
Specific Cancer

scholarly journals Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

Cell ◽  
2003 ◽  
Vol 113 (5) ◽  
pp. 643-655 ◽  
Author(s):  
Ian Chambers ◽  
Douglas Colby ◽  
Morag Robertson ◽  
Jennifer Nichols ◽  
Sonia Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Functional Expression ◽  
Expression Cloning

Transcutaneous immunization against cancer using solid-in-oil nanodispersions

MedChemComm ◽  
2015 ◽  
Vol 6 (7) ◽  
pp. 1387-1392 ◽  
Author(s):  
Yuya Hirakawa ◽  
Rie Wakabayashi ◽  
Ayaka Naritomi ◽  
Masato Sakuragi ◽  
Noriho Kamiya ◽  
...  
Keyword(s):  
Cancer Immunity ◽  
Cancer Antigens ◽  
Transcutaneous Immunization ◽  
Specific Cancer

Solid-in-oil nanodispersions allowed cancer antigens to penetrate into skin to induce antigen-specific cancer immunity.

scholarly journals Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression

Oncogene ◽  
2004 ◽  
Vol 23 (58) ◽  
pp. 9419-9426 ◽  
Author(s):  
Mirna Mourtada-Maarabouni ◽  
Lucy Kirkham ◽  
Farzin Farzaneh ◽  
Gwyn T Williams
Keyword(s):  
Functional Expression ◽  
Expression Cloning ◽  
Antisense Expression

A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes

2011 ◽  
Vol 39 (2) ◽  
pp. 482-486 ◽  
Author(s):  
Gwyn T. Williams ◽  
Mirna Mourtada-Maarabouni ◽  
Farzin Farzaneh
Keyword(s):  
T Lymphocytes ◽  
Critical Role ◽  
Mammalian Target Of Rapamycin ◽  
Growth Arrest ◽  
Normal Growth ◽  
Functional Expression ◽  
Expression Cloning ◽  
Human T Lymphocytes ◽  
Non Coding Rna ◽  
Terminal Oligopyrimidine

Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5′-TOP (5′-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway. GAS5 was identified by functional expression cloning and is necessary and sufficient for normal growth arrest in both leukaemic and untransformed human T-lymphocytes. GAS5 is also required for the inhibitory effects of rapamycin and its analogues on T-cells. The striking functional effects of GAS5 may be mediated through the snoRNAs (small nucleolar RNAs) encoded in its introns and/or through the unusual folding of the mRNA itself, which sequesters, and therefore inhibits, the glucocorticoid receptor.

scholarly journals Functional Expression Cloning and Characterization of SFT, a Stimulator of Fe Transport

1997 ◽  
Vol 139 (4) ◽  
pp. 895-905 ◽  
Author(s):  
Jesus A. Gutierrez ◽  
Jianming Yu ◽  
Susan Rivera ◽  
Marianne Wessling-Resnick
Keyword(s):  
Membrane Transport ◽  
Untranslated Region ◽  
Xenopus Oocytes ◽  
Functional Expression ◽  
Expression Cloning ◽  
Cation Diffusion ◽  
Recycling Endosomes ◽  
Fe Uptake ◽  
Stimulation Of

A stimulator of Fe transport (SFT) was identified by functional expression cloning in Xenopus oocytes. SFT-mediated transport has properties defined for transferrin-independent Fe uptake, but its cytolocalization in recycling endosomes and the observed stimulation of transferrin-bound Fe assimilation indicate a key role in intracellular Fe membrane transport as well. SFT has six predicted transmembranous domains and a functionally important RExxE motif that resembles domains involved in yeast Fe transport and Fe-binding by ferritin L-chains. The observation that SFT oligomerizes, along with other structural and mechanistic features, suggests it may be a member of either the ATP-binding cassette or cation diffusion facilitator families. The 3′ untranslated region of SFT contains a translation inhibitory element and inhibition of SFT expression in Xenopus oocytes was found to be relieved by coinjection of transcripts from other defined cDNAs that are also described in this report. SFT is the first component of the mammalian Fe membrane transport machinery to be identified.

scholarly journals Functional expression cloning reveals proapoptotic role for protein phosphatase 4

2003 ◽  
Vol 10 (9) ◽  
pp. 1016-1024 ◽  
Author(s):  
M Mourtada-Maarabouni ◽  
L Kirkham ◽  
B Jenkins ◽  
J Rayner ◽  
T J Gonda ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Functional Expression ◽  
Expression Cloning

scholarly journals Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes.

1994 ◽  
Vol 269 (4) ◽  
pp. 3017-3021
Author(s):  
M. Bissig ◽  
B. Hagenbuch ◽  
B. Stieger ◽  
T. Koller ◽  
P.J. Meier
Keyword(s):  
Transport System ◽  
Rat Hepatocytes ◽  
Functional Expression ◽  
Expression Cloning ◽  
Sulfate Transport
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