scholarly journals The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

2016 ◽  
Vol 7 (2) ◽  
pp. e2108-e2108 ◽  
Author(s):  
T Colangelo ◽  
G Polcaro ◽  
P Ziccardi ◽  
L Muccillo ◽  
M Galgani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Immunogenic Cell Death ◽  
Human Colorectal Cancer ◽  
Drug Induced ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Altholactone Induces Apoptotic Cell Death in Human Colorectal Cancer Cells

2011 ◽  
Vol 26 (6) ◽  
pp. 926-931 ◽  
Author(s):  
Nizar M. Mhaidat ◽  
Kalid K. Abdul-Razzak ◽  
Ahmad S. Alkofahi ◽  
Aseera M. Alsarhan ◽  
Ahmad N. Aldaher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Coptidis rhizoma Induces Apoptosis in Human Colorectal Cancer Cells SNU-C4

2004 ◽  
Vol 32 (06) ◽  
pp. 873-882 ◽  
Author(s):  
Youn Jung Kim ◽  
Soon Ah Kang ◽  
Mee Suk Hong ◽  
Hae Jeong Park ◽  
Mi-Ja Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Coptidis Rhizoma ◽  
Human Colorectal Cancer Cells

Coptidis rhizoma has been used as traditional herb medicine in gastrointestinal disorders in the Eastern Asia. We investigated whether the anticancer effects of the C. rhizoma induced apoptosis on human colorectal cancer cells SNU-C4. The cytotoxic effect of C. rhizoma was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. To determine apoptotic cell death, 4,6-diamidino-2-phenylindole (DAPI) staining, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) and caspase-3 enzyme assay were performed. In this study, C. rhizoma treatment (100 μg/ml) revealed typical morphological apoptotic features. Additionally, C. rhizoma treatment (100 μg/ml) increased levels of BAX and CASPASE-3, and decreased levels of BCL-2. Caspase-3 enzyme activity by treatment of C. rhizoma (100 μg/ml) also significantly increased compared to the control (p<0.05). These data indicate that C. rhizoma caused cell death by apoptosis through caspase pathways on human colorectal cancer cells SNU-C4.

scholarly journals Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells

2003 ◽  
Vol 374 (2) ◽  
pp. 481-488 ◽  
Author(s):  
Alun HUGHES ◽  
Nicholas I. SMITH ◽  
Heather M. WALLACE
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cell Number ◽  
Human Colorectal Cancer ◽  
Morphological Examination ◽  
Drug Induced ◽  
Colorectal Cancer Cells ◽  
Polyamine Content ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition of ornithine decarboxylase (the first enzyme of the polyamine biosynthetic pathway), induction of polyamine oxidase and spermidine/spermine N1-acetyltransferase (the enzymes responsible for polyamine catabolism) and induction of polyamine export all contributed to the decreased intracellular polyamine content. Morphological examination of the cells showed typical signs of apoptosis, and this was confirmed by DNA fragmentation and measurement of caspase-3-like activity. Re-addition of spermidine to the cells partially prevented apoptosis and recovered the cell number. Thus polyamines appear to be an integral part of the signalling pathway mediating NSAID toxicity in human colorectal cancer cells, and may therefore also be important in cancer chemoprevention in humans.

scholarly journals Oral poliovirus vaccine-induced programmed cell death involves both intrinsic and extrinsic pathways in human colorectal cancer cells

2018 ◽  
Vol Volume 7 ◽  
pp. 95-105
Author(s):  
Sareh Zhand ◽  
Seyed Masoud Hosseini ◽  
Alijan Tabarraei ◽  
Mohsen Saeidi ◽  
Marie Saghaeian Jazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cancer Cells ◽  
Oral Poliovirus Vaccine ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells
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