The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells

Tumor Biology ◽  
2014 ◽  
Vol 36 (5) ◽  
pp. 3447-3455 ◽  
Author(s):  
Lijun Ye ◽  
Gang Yuan ◽  
Fei Xu ◽  
Yueli Sun ◽  
Ziyan Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Small Molecule ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Small Molecule Compound ◽  
Human Colorectal Cancer Cells

Altholactone Induces Apoptotic Cell Death in Human Colorectal Cancer Cells

2011 ◽  
Vol 26 (6) ◽  
pp. 926-931 ◽  
Author(s):  
Nizar M. Mhaidat ◽  
Kalid K. Abdul-Razzak ◽  
Ahmad S. Alkofahi ◽  
Aseera M. Alsarhan ◽  
Ahmad N. Aldaher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells

2016 ◽  
Vol 370 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Sean M. Ronnekleiv-Kelly ◽  
Manabu Nukaya ◽  
Carol J. Díaz-Díaz ◽  
Bryant W. Megna ◽  
Patrick R. Carney ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Aryl Hydrocarbon Receptor ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Colorectal Cancer ◽  
Aryl Hydrocarbon ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Coptidis rhizoma Induces Apoptosis in Human Colorectal Cancer Cells SNU-C4

2004 ◽  
Vol 32 (06) ◽  
pp. 873-882 ◽  
Author(s):  
Youn Jung Kim ◽  
Soon Ah Kang ◽  
Mee Suk Hong ◽  
Hae Jeong Park ◽  
Mi-Ja Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Coptidis Rhizoma ◽  
Human Colorectal Cancer Cells

Coptidis rhizoma has been used as traditional herb medicine in gastrointestinal disorders in the Eastern Asia. We investigated whether the anticancer effects of the C. rhizoma induced apoptosis on human colorectal cancer cells SNU-C4. The cytotoxic effect of C. rhizoma was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. To determine apoptotic cell death, 4,6-diamidino-2-phenylindole (DAPI) staining, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) and caspase-3 enzyme assay were performed. In this study, C. rhizoma treatment (100 μg/ml) revealed typical morphological apoptotic features. Additionally, C. rhizoma treatment (100 μg/ml) increased levels of BAX and CASPASE-3, and decreased levels of BCL-2. Caspase-3 enzyme activity by treatment of C. rhizoma (100 μg/ml) also significantly increased compared to the control (p<0.05). These data indicate that C. rhizoma caused cell death by apoptosis through caspase pathways on human colorectal cancer cells SNU-C4.

scholarly journals Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

2017 ◽  
Vol 8 (10) ◽  
pp. e3087-e3087 ◽  
Author(s):  
Sen Wang ◽  
Kexin Wang ◽  
Chundong Zhang ◽  
Wanfeng Zhang ◽  
Qian Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Betulinic Acid ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Colorectal Cancer Cells

Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo

2018 ◽  
Vol 233 (9) ◽  
pp. 7134-7142 ◽  
Author(s):  
Long-Bin Jeng ◽  
Bharath Kumar Velmurugan ◽  
Ming-Cheng Chen ◽  
Hsi-Hsien Hsu ◽  
Tsung-Jung Ho ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Colorectal Cancer Cells
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