scholarly journals How to manage large-scale collaborative genomics research projects?

2017 ◽  
Vol 25 (5) ◽  
pp. 656-656
Author(s):  
Erinija Pranckevičienė ◽  
Vaidutis Kučinskas
Keyword(s):  
Large Scale ◽  
Research Projects ◽  
Genomics Research

scholarly journals Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Young-Dan Cho ◽  
Woo-Jin Kim ◽  
Hyun-Mo Ryoo ◽  
Hong-Gee Kim ◽  
Kyoung-Hwa Kim ◽  
...  
Keyword(s):  
Large Scale ◽  
Periodontal Diseases ◽  
Research Trends ◽  
Main Body ◽  
Research Projects ◽  
Encode Project ◽  
Dna Elements ◽  
Crucial Information ◽  
Future Direction ◽  
Systemic Health

Abstract Background The Encyclopedia of DNA Elements (ENCODE) project has advanced our knowledge of the functional elements in the genome and epigenome. The aim of this article was to provide the comprehension about current research trends from ENCODE project and establish the link between epigenetics and periodontal diseases based on epigenome studies and seek the future direction. Main body Global epigenome research projects have emphasized the importance of epigenetic research for understanding human health and disease, and current international consortia show an improved interest in the importance of oral health with systemic health. The epigenetic studies in dental field have been mainly conducted in periodontology and have focused on DNA methylation analysis. Advances in sequencing technology have broadened the target for epigenetic studies from specific genes to genome-wide analyses. Conclusions In line with global research trends, further extended and advanced epigenetic studies would provide crucial information for the realization of comprehensive dental medicine and expand the scope of ongoing large-scale research projects.

scholarly journals A Large-Scale COVID-19 Twitter Chatter Dataset for Open Scientific Research—An International Collaboration

Epidemiologia ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 315-324
Author(s):  
Juan M. Banda ◽  
Ramya Tekumalla ◽  
Guanyu Wang ◽  
Jingyuan Yu ◽  
Tuo Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Social Dynamics ◽  
Additional Data ◽  
Open Data ◽  
Data Sources ◽  
Research Projects ◽  
Research Groups ◽  
The World ◽  
Data Source

As the COVID-19 pandemic continues to spread worldwide, an unprecedented amount of open data is being generated for medical, genetics, and epidemiological research. The unparalleled rate at which many research groups around the world are releasing data and publications on the ongoing pandemic is allowing other scientists to learn from local experiences and data generated on the front lines of the COVID-19 pandemic. However, there is a need to integrate additional data sources that map and measure the role of social dynamics of such a unique worldwide event in biomedical, biological, and epidemiological analyses. For this purpose, we present a large-scale curated dataset of over 1.12 billion tweets, growing daily, related to COVID-19 chatter generated from 1 January 2020 to 27 June 2021 at the time of writing. This data source provides a freely available additional data source for researchers worldwide to conduct a wide and diverse number of research projects, such as epidemiological analyses, emotional and mental responses to social distancing measures, the identification of sources of misinformation, stratified measurement of sentiment towards the pandemic in near real time, among many others.

scholarly journals Towards empathetic autism research: Developing an autism-specific Research Passport

2020 ◽  
Author(s):  
Maria Ashworth ◽  
Laura Crane ◽  
Robyn Steward ◽  
Melissa Bovis ◽  
Liz Pellicano
Keyword(s):  
Large Scale ◽  
Preliminary Evaluation ◽  
Research Projects ◽  
Community Members ◽  
Ongoing Research ◽  
Negative Experiences ◽  
Autism Research ◽  
Iterative Design ◽  
Large Scale Testing ◽  
Autistic Adults

Despite a dramatic increase in the amount of autism research taking place, autistic adults often report negative experiences of participating in such research. In other areas where community members report dissatisfaction (e.g., healthcare, criminal justice), ‘passports’ or ‘toolkits’ have been developed. In the current project, we created a Research Passport that could be used by autistic adults and autism researchers when engaging in research. Using a participatory framework, we designed and developed a Research Passport via an iterative design process. First, focus groups with autistic adults (n=9) and autism researchers (n=6) were used to elicit initial ideas for a Research Passport. Findings showed that the Research Passport (1) was perceived to be a useful idea, but not a panacea for all issues in autism research, (2) needed to be universal and flexible, and (3) could have a broad remit (e.g., to record scores on commonly-used standardized tasks that could, with permission, be shared with different researchers). Next, a preliminary evaluation of a prototype Research Passport was conducted via usability testing in three ongoing research projects. Nine autistic participants provided feedback (via a survey), as did three researchers (via interviews). We identified three themes from these data, highlighting how the Research Passport: (1) promoted positive participant-researcher relationships, (2) provided a structure and framework to support existing practices, and (3) needed to be adapted slightly to facilitate usability and manage expectations. Overall, the Research Passport was perceived to be useful in promoting empathetic autism research. Further design and large-scale testing are warranted.

Using practice analytics to understand variation and support re-flective practice: A protocol for a comprehensive digital health re-search program (Preprint)

2021 ◽  
Author(s):  
Anna Janssen ◽  
Stella Talic ◽  
Dragan Gasevic ◽  
Tim Shaw
Keyword(s):  
Clinical Practice ◽  
Professional Learning ◽  
Research Program ◽  
Health Professionals ◽  
Large Scale ◽  
Digital Health ◽  
Quality Care ◽  
Academic Disciplines ◽  
Research Projects ◽  
Electronic Data

BACKGROUND There is an increasing quantity of electronic data sitting within the health system. This data has untapped potential to improve clinical practice if extracted efficiently and harnessed to change the behavior of health professionals. Furthermore, there is an in-creasing expectation by government and peak bodies that both individual health pro-fessionals and healthcare organisations will be utilising electronic data for licensing and accreditation. OBJECTIVE The objective of this study is to understand how digital technology for harnessing elec-tronic health data can be used effectively by health professionals to support practice reflection. METHODS A multidisciplinary approach was used to connect academic experts from core disci-plines of Health and Medicine, Education and Learning Sciences, and Engineering and Information Communication Technology (ICT) with government and health services partners to identify key problems preventing the healthcare industry from using elec-tronic data to support health professional learning. The approach was used to design a large-scale research program to solve this problem. The program will be delivered by doctoral candidates undertaking research projects with discrete aims that run in paral-lel to achieve the program’s overarching objectives. RESULTS The research program commenced in March 2020. Since this time four PhD Candidates have commenced their research projects. Preliminary findings are expected from indi-vidual projects in late 2021. CONCLUSIONS The approach used in this research program has potential to successfully unpack elec-tronic data siloed within clinical sites and enable health professionals to use it to reflect on their practice and deliver high quality care. Key outputs of the program will include fostering stronger connections between industry and academia, interlinking doctoral research projects to solve complex problems, the creation of new knowledge for clinical sites on how data can be used to understand performance and strengthening profes-sional development programs to align them with clinical practice. Key contributions of this paper include presenting a description of Practice Analytics, and describing the foundational academic disciplines that contribute to it. It will also present a method for designing a Practice Analytics research program.

scholarly journals Sustainability of digital humanities projects as a publication and documentation challenge

2020 ◽  
Vol 76 (5) ◽  
pp. 1019-1031 ◽  
Author(s):  
Jennifer Edmond ◽  
Francesca Morselli
Keyword(s):  
Digital Humanities ◽  
Large Scale ◽  
Explicit Knowledge ◽  
Public Investment ◽  
Holistic Approach ◽  
Research Projects ◽  
Content Type ◽  
Sustainability Planning ◽  
Project Sustainability ◽  
New Perspective

PurposeThis paper proposes a new perspective on the enormous and unresolved challenge to existing practices of publication and documentation posed by the outputs of digital research projects in the humanities, where much good work is being lost due to resource or technical challenges.Design/methodology/approachThe paper documents and analyses both the existing literature on promoting sustainability for the outputs of digital humanities projects and the innovative approach of a single large-scale project.FindingsThe findings of the research presented show that sustainability planning for large-scale research projects needs to consider data and technology but also community, communications and process knowledge simultaneously. In addition, it should focus not only on a project as a collection of tangible and intangible assets, but also on the potential user base for these assets and what these users consider valuable about them.Research limitations/implicationsThe conclusions of the paper have been formulated in the context of one specific project. As such, it may amplify the specificities of this project in its results.Practical implicationsAn approach to project sustainability following the recommendations outlined in this paper would include a number of uncommon features, such as a longer development horizon, wider perspective on project results, and an audit of tacit and explicit knowledge.Social ImplicationsThese results can ultimately preserve public investment in projects.Originality/valueThis paper supplements more reductive models for project sustainability with a more holistic approach that others may learn from in mapping and sustaining user value for their projects for the medium to long terms.

scholarly journals ‘You should at least ask’. The expectations, hopes and fears of rare disease patients on large-scale data and biomaterial sharing for genomics research

2016 ◽  
Vol 24 (10) ◽  
pp. 1403-1408 ◽  
Author(s):  
Pauline McCormack ◽  
Anna Kole ◽  
Sabina Gainotti ◽  
Deborah Mascalzoni ◽  
Caron Molster ◽  
...  
Keyword(s):  
Rare Disease ◽  
Large Scale ◽  
Large Scale Data ◽  
Genomics Research ◽  
Scale Data

Ontwikkelingen en Problemen Bij Automatisch Vertalen

1984 ◽  
Vol 19 ◽  
pp. 59-71
Author(s):  
A.G. Sciarone
Keyword(s):  
Data Processing ◽  
Data Storage ◽  
Critical Analysis ◽  
Large Scale ◽  
Research Projects ◽  
Automatic Translation ◽  
Linguistic Research ◽  
The World ◽  
Translation Systems ◽  
Made In

In the fifties and sixties a great deal of money and time was spent on the development of automatic translation systems. Because of the meagre results and sombre perspectives all large scale research projects were abandoned. The eighties show a renewed interest in the field of automatic translating. It is, therefore, a valid question whether old problems have been solved and new perspectives have been uncovered. A critical analysis shows that progress has been made in the domains of hardware (speed of data processing and data storage) and the organisation of data. The basic linguis-tic problems have not, however, been solved. Linguistic research that is not first and foremost directed at descriptive (instead of representational) problems and at fundamental problems such as the relation between syntax, semantics and knowledge of the world is subject to the same fate as the research into automatic translating in the fifties.

Sign in / Sign up

Export Citation Format

Share Document