Relationship between ambulatory arterial stiffness index and subclinical target organ damage in hypertensive patients

Chronic kidney disease (CKD) affects approximately two million people (in a population of 20 million) in Romania. Hypertension is often associated with CKD and both (hypertension and CKD) are risk factors for cardiovascular (CV) events. Ambulatory blood pressure monitoring (ABPM) is increasingly used all around the world for the diagnosis and monitoring of BP (blood pressure) because it is proven that the ABPM is superior to office BP measurements in evaluating patients with hypertension, with or without CKD. Reduced nocturnal BP fall (non-dipping or reverse-dipping patterns) is associated with target organ damage, especially kidney disease and the proportion of non-dippers and reverse-dippers patients increases progressively with the reduction of glomerular filtration rate (GFR). Another ABPM parameter, ambulatory arterial stiffness index (AASI), is an index which was recently proposed for the evaluation of arterial stiffness (a better tool than PP). It has prognostic value for cardiac death and stroke and several studies have showed that is negatively related to eGFR and is positively related to albuminuria. Hyperbaric area index (HBI) might be considered a novel sensitive marker [independent of patterns of NBPC (nocturnal BP change)] for the reduction of kidney function. These facts suggest that ABPM offers multiple useful data with impact, not only in future CV and renal outcomes assessment, but also in the treatment and management of hypertensive patients with CKD.

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Association between home arterial stiffness index and target organ damage in hypertension: Comparison with pulse wave velocity and augmentation index

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.09.027 ◽

2011 ◽

Vol 219 (2) ◽

pp. 637-642 ◽

Cited By ~ 14

Author(s):

Yoshio Matsui ◽

Joji Ishikawa ◽

Seiichi Shibasaki ◽

Kazuyuki Shimada ◽

Kazuomi Kario

Keyword(s):

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Augmentation Index ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Arterial Stiffness Index

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Increased Ambulatory Arterial Stiffness Index Is Associated With Target Organ Damage in Primary Hypertension

Hypertension ◽

10.1161/01.hyp.0000236599.91051.1e ◽

2006 ◽

Vol 48 (3) ◽

pp. 397-403 ◽

Cited By ~ 95

Author(s):

Giovanna Leoncini ◽

Elena Ratto ◽

Francesca Viazzi ◽

Valentina Vaccaro ◽

Angelica Parodi ◽

...

Keyword(s):

Arterial Stiffness ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Primary Hypertension ◽

Stiffness Index ◽

Arterial Stiffness Index

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The ambulatory arterial stiffness index and target-organ damage in Chinese patients with chronic kidney disease

BMC Nephrology ◽

10.1186/1471-2369-14-257 ◽

2013 ◽

Vol 14 (1) ◽

Cited By ~ 3

Author(s):

Cheng Wang ◽

Jun Zhang ◽

Cui-Cui Li ◽

Wen-Yu Gong ◽

Xun Liu ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Arterial Stiffness ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Chinese Patients ◽

Stiffness Index ◽

Arterial Stiffness Index

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Association of Target Organ Damage With Three Arterial Stiffness Indexes According to Blood Pressure Dipping Status in Untreated Hypertensive Patients

American Journal of Hypertension ◽

10.1038/ajh.2010.156 ◽

2010 ◽

Vol 23 (12) ◽

pp. 1265-1272 ◽

Cited By ~ 28

Author(s):

H. Triantafyllidi ◽

S. Tzortzis ◽

J. Lekakis ◽

I. Ikonomidis ◽

C. Arvaniti ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Stiffness ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Hypertensive Patients ◽

Blood Pressure Dipping

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AMBULATORY ARTERIAL STIFFNESS MONITORING IN PATIENTS WITH ASTHMA

The Russian Archives of Internal Medicine ◽

10.20514/2226-6704-2019-9-4-301-307 ◽

2019 ◽

Vol 9 (4) ◽

pp. 301-307

Author(s):

N. A. Karoli ◽

O. T. Zarmanbetova ◽

A. P. Rebrov

Keyword(s):

Arterial Stiffness ◽

Augmentation Index ◽

Target Organ Damage ◽

Vascular Wall ◽

Organ Damage ◽

Stiffness Index ◽

Control Group ◽

Target Organs ◽

Gender And Age ◽

Arterial Stiffness Index

Cardiovascular disease is one of the major causes of death throughout the world. Early detection of target organ damage is important for more successful prevention of cardiovascular diseases and improvement of patient outcomes. One of these target organs is the vascular wall, and its damage consists in loss of elastic properties and increase in stiffness. Many studies have shown that the increasing stiffness of the vascular wall is an independent predictor of cardiovascular risk. Objective: To evaluate parameters of the ambulatory arterial stiffness monitoring in patients with bronchial asthma. Materials and methods. The study enrolled 119 patients with asthma. The group of control included 30 practically healthy volunteers comparable by gender and age with the patients of the main group. Each patient underwent ambulatory blood pressure and arterial stiffness monitoring using BPLab MnSDP-2 device (Petr Telegin, Russia). Results: In patients with asthma higher values of augmentation index, arterial stiffness index and pulse wave velocity in the aorta in comparison with patients of the control group, as well as violation of the 24-hour profile of arterial stiffness were noted. Conclusion. Patients with asthma demonstrated significantly increased arterial stiffness in comparison with control group.

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Uric Acid Is Not Associated With Blood Pressure Phenotypes and Target Organ Damage According to Blood Pressure Phenotypes

American Journal of Hypertension ◽

10.1093/ajh/hpaa130 ◽

2020 ◽

Author(s):

Anping Cai ◽

Lin Liu ◽

Mohammed Siddiqui ◽

Dan Zhou ◽

Jiyan Chen ◽

...

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Arterial Stiffness ◽

Blood Pressure Monitoring ◽

Target Organ Damage ◽

Organ Damage ◽

Left Ventricular ◽

Target Organ ◽

Uncontrolled Hypertension ◽

Hypertensive Patients

Abstract BACKGROUND Hypertensive patients with increased serum uric acid (SUA) are at increased cardiovascular (CV) risks. Both the European and American hypertension guidelines endorse the utilization of 24 h-ambulatory blood pressure monitoring (24 h-ABPM) for hypertensive patients with increased CV risk. While there is difference in identifying uric acid as a CV risk factor between the European and American guidelines. Therefore, it is unknown whether 24 h-ABPM should be used routinely in hypertensive patients with increased SUA. METHODS To address this knowledge gap, we investigated (i) the correlation between SUA and 24 h-ABP; (ii) the association between SUA and blood pressure (BP) phenotypes (controlled hypertension [CH], white-coat uncontrolled hypertension [WCUH], masked uncontrolled hypertension [MUCH], and sustained uncontrolled hypertension [SUCH]); (iii) the association between SUA and target organ damage (TOD: microalbuminuria, left ventricular hypertrophy [LVH], and arterial stiffness) according to BP phenotypes. RESULTS In 1,336 treated hypertensive patients (mean age 61.2 and female 55.4%), we found (i) there was no correlation between SUA and 24 h, daytime, and nighttime systolic blood pressure/diastolic blood pressure, respectively; (ii) in reference to CH, SUA increase was not associated WCUH (odds ratio [OR] 0.968, P = 0.609), MUCH (OR 1.026, P = 0.545), and SUCH (OR 1.003, P = 0.943); (iii) the overall prevalence of microalbuminuria, LVH, and arterial stiffness was 2.3%, 16.7%, and 23.2%, respectively. After adjustment for covariates, including age, sex, smoking, body mass index, diabetes mellitus, and estimated glomerular filtration rate, there was no association between SUA and TOD in all BP phenotypes. CONCLUSIONS These preliminary findings did not support routine use of 24 h-ABPM in treated hypertensive patients with increased SUA.

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