AMBULATORY ARTERIAL STIFFNESS MONITORING IN PATIENTS WITH ASTHMA

Cardiovascular disease is one of the major causes of death throughout the world. Early detection of target organ damage is important for more successful prevention of cardiovascular diseases and improvement of patient outcomes. One of these target organs is the vascular wall, and its damage consists in loss of elastic properties and increase in stiffness. Many studies have shown that the increasing stiffness of the vascular wall is an independent predictor of cardiovascular risk. Objective: To evaluate parameters of the ambulatory arterial stiffness monitoring in patients with bronchial asthma. Materials and methods. The study enrolled 119 patients with asthma. The group of control included 30 practically healthy volunteers comparable by gender and age with the patients of the main group. Each patient underwent ambulatory blood pressure and arterial stiffness monitoring using BPLab MnSDP-2 device (Petr Telegin, Russia). Results: In patients with asthma higher values of augmentation index, arterial stiffness index and pulse wave velocity in the aorta in comparison with patients of the control group, as well as violation of the 24-hour profile of arterial stiffness were noted. Conclusion. Patients with asthma demonstrated significantly increased arterial stiffness in comparison with control group.

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Association between home arterial stiffness index and target organ damage in hypertension: Comparison with pulse wave velocity and augmentation index

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.09.027 ◽

2011 ◽

Vol 219 (2) ◽

pp. 637-642 ◽

Cited By ~ 14

Author(s):

Yoshio Matsui ◽

Joji Ishikawa ◽

Seiichi Shibasaki ◽

Kazuyuki Shimada ◽

Kazuomi Kario

Keyword(s):

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Augmentation Index ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Arterial Stiffness Index

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DAILY VARIABILITY OF ARTERIAL STIFFNESS INDEX IN RELATION TO TARGET ORGAN DAMAGE AND SEVERITY OF ARTERIAL HYPERTENSION

Journal of Hypertension ◽

10.1097/01.hjh.0000539491.80964.81 ◽

2018 ◽

Vol 36 (Supplement 1) ◽

pp. e179

Author(s):

A. Merezhanova ◽

E. Tarlovskaya ◽

K. Mazalov ◽

M. Mazalova ◽

N. Kamardina ◽

...

Keyword(s):

Arterial Stiffness ◽

Arterial Hypertension ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Daily Variability ◽

Arterial Stiffness Index

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24-Hour Blood Pressure Monitoring: Association Between AASI (Ambulatory Arterial Stiffness Index) and Subclinical Target Organ Damage

High Blood Pressure & Cardiovascular Prevention ◽

10.2165/00151642-200714030-00171 ◽

2007 ◽

Vol 14 (3) ◽

pp. 145-196

Author(s):

F Natale ◽

M A Tedesco ◽

R Calabrò

Keyword(s):

Blood Pressure ◽

Arterial Stiffness ◽

Blood Pressure Monitoring ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Pressure Monitoring ◽

Arterial Stiffness Index

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THE PARTICULARITIES OF ABPM PARAMETERS IN HYPERTENSIVE PATIENTS WITH NON-DIALYSIS CKD

Romanian Medical Journal ◽

10.37897/rmj.2017.4.3 ◽

2017 ◽

Vol 64 (4) ◽

pp. 279-283

Author(s):

Alexandru Minca ◽

◽

Mihai Comsa ◽

Maria Mirabela Manea ◽

Maria Daniela Tanasescu ◽

...

Keyword(s):

Blood Pressure ◽

Kidney Disease ◽

Arterial Stiffness ◽

Blood Pressure Monitoring ◽

Target Organ Damage ◽

Organ Damage ◽

Stiffness Index ◽

Area Index ◽

Hypertensive Patients ◽

Arterial Stiffness Index

Chronic kidney disease (CKD) affects approximately two million people (in a population of 20 million) in Romania. Hypertension is often associated with CKD and both (hypertension and CKD) are risk factors for cardiovascular (CV) events. Ambulatory blood pressure monitoring (ABPM) is increasingly used all around the world for the diagnosis and monitoring of BP (blood pressure) because it is proven that the ABPM is superior to office BP measurements in evaluating patients with hypertension, with or without CKD. Reduced nocturnal BP fall (non-dipping or reverse-dipping patterns) is associated with target organ damage, especially kidney disease and the proportion of non-dippers and reverse-dippers patients increases progressively with the reduction of glomerular filtration rate (GFR). Another ABPM parameter, ambulatory arterial stiffness index (AASI), is an index which was recently proposed for the evaluation of arterial stiffness (a better tool than PP). It has prognostic value for cardiac death and stroke and several studies have showed that is negatively related to eGFR and is positively related to albuminuria. Hyperbaric area index (HBI) might be considered a novel sensitive marker [independent of patterns of NBPC (nocturnal BP change)] for the reduction of kidney function. These facts suggest that ABPM offers multiple useful data with impact, not only in future CV and renal outcomes assessment, but also in the treatment and management of hypertensive patients with CKD.

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Parameters of arterial stiffness in hypertensive patients with and without subclinical carotid atherosclerosis

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2021-27-4-427-435 ◽

2021 ◽

Vol 27 (4) ◽

pp. 427-435

Author(s):

V. E. Gumerova ◽

S. A. Sayganov ◽

V. V. Gomonova

Keyword(s):

Arterial Stiffness ◽

Pulse Pressure ◽

Augmentation Index ◽

Subclinical Atherosclerosis ◽

Stiffness Index ◽

Control Group ◽

Hypertensive Patients ◽

Significant Difference ◽

Arterial Stiffness Index ◽

Plaque Detection

Objective. To assess the relationship between arterial stiffness parameters in hypertensive patients with and without atherosclerotic lesions.Design and methods. We included 127 subjects who were divided into 3 groups: patients with hypertension (HTN) without atherosclerosis (n = 42); patients with HTN and subclinical atherosclerosis (SА) (n = 52) and control group which consisted of individuals without HTN, SA, or coronary artery disease (n = 33). All groups matched by age and gender. All subjects underwent following examinations: ultrasonography of extracranial segments of carotid arteries, 24-hour blood pressure monitoring with the assessment of arterial stiffness parameters.Results. In subjects with HTN compared to controls, pulse wave velocity in aorta (PWVao) was significantly higher (11,3 ± 1,5; 12,3 ± 1,8 vs 10,4 ± 1,3 m/s; p < 0,05), as well as pulse pressure (PP) (46,4 ± 9,8; 45,6 ± 10,6 vs 39,9 ± 6,5 mmHg; p < 0,05), central pulse pressure (PPао) (35,5 ± 8,5; 34,9 ± 8,5 vs 30,9 ± 5,4 mmHg; p < 0,05), and arterial stiffness index (ASI) (141 (127, 159); 139 (128,5, 160,5) vs 126 (118, 138) mmHg; p < 0,05). In subjects with HTN and SA, PWVao was significantly higher compared to other groups (p < 0,05). No significant difference in augmentation index was found (–32,5 (–45, –12); –22 (–36, –12); –37 (–50, –17); p = 0,25). Аmbulatory arterial stiffness index was higher in controls (0,5 ± 0,2) compared to HTN group (0,4 ± 0,2; p = 0,05), while HTN and SA group did not differ significantly (0,5 ± 0,2; p = 0,3). PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection.Conclusions. In HTN patients, arterial stiffness is changed compared to healthy individuals. PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection. In patients with HTN and SA arterial stiffness is higher, which might have additional predictive value in risk stratification.

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Relationship between ambulatory arterial stiffness index and subclinical target organ damage in hypertensive patients

Hypertension Research ◽

10.1038/hr.2010.195 ◽

2010 ◽

Vol 34 (2) ◽

pp. 180-186 ◽

Cited By ~ 29

Author(s):

Ángel García-García ◽

Manuel A Gómez-Marcos ◽

José I Recio-Rodriguez ◽

Luis J González-Elena ◽

Javier Parra-Sanchez ◽

...

Keyword(s):

Arterial Stiffness ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Hypertensive Patients ◽

Arterial Stiffness Index

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P3460Structural and functional changes of vascular wall in women of perimenopausal period with long-term menopausal hormone therapy

European Heart Journal ◽

10.1093/eurheartj/ehz745.0333 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

S N Tolstov ◽

I A Salov ◽

A P Rebrov

Keyword(s):

Arterial Stiffness ◽

Functional State ◽

Brachial Artery ◽

Vascular Wall ◽

Main Group ◽

Stiffness Index ◽

Control Group ◽

Functional Changes ◽

Postmenopausal Period ◽

Arterial Stiffness Index

Abstract Introduction Features of changes in the vascular wall in women of the menopausal period are not sufficiently illuminated. Most of the studies evaluating the effect of menopausal hormonal therapy (MHT) on the structural and functional state of the vascular wall were limited to the time frame from several months to 1–3 years, which distinguishes them from our study. Purpose To evaluate structural and functional changes in the vascular wall in women of early postmenopausal period with prolonged use of low doses of MHT 1 mg of 17β-estradiol (E2) and 2 mg drospirenone (DRSP). Methods The study included 162 women in the early postmenopausal period with climacteric syndrome were divided into 2 groups: the main group of 84 women assigned MHT 1 mg E2 /2 mg DRSP, control group of 78 women who did not receive MHT. Duration of follow-up 5,2 (4,8; 5,7) years. Explored pulse wave velocity (PWV). Bbrachial blood pressure was measured non-invasively over the 24 h with an electronic, oscillometric, automated device (BPLab) with the assessment of 24-h central arterial pressure (CAP), aortic augmentation index (AIx), arterial stiffness index (ASI); ambulatory arterial stiffness index (AASI). Endothelium-dependent vasodilation (EDV) of the brachial artery was evaluated. Results In women of the main group PWV made up 7.19±1.7 m/s initial and 7.53±1.3 m/s to the end of the study (p>0.05); in the control group - 7,21±1.8 m/s and 7.95±1.9 m/s (p<0.001). In the women of the main group by the end of the study a decrease in the CAP was noted from 38.4±6.2 to 35.3±4.1 mm Hg. (p<0.001), in the women of the control group there were no changes of 41.4±9.6 and 40.9±9.8 mm Hg. (p<0.001 between women of both groups at the end of the study). In women of the control group, a significant increase in AIx was found from 31.0 (20.0; 35.0)% initially to 33.0 (29.0; 37.0)% by the end of the study (p<0.05) and no changes in women of the main group – 27.0 (20.0; 35.0)% and 28.0 (20.0; 33.0)%. Multidirectional changes ASI were revealed: a decrease in women of the main group from 132.0 (121.0; 142.0) to 127.0 (115.5; 137.0) cu and an increase from 133.0 (111.0; 155.0) to 148.0 (134.2; 171.0) cu in women of the control group (p<0.01 between women of both groups at the end of the study). By the end of the study, there was a decrease in AASI in women of the main group from 0.379 (0.320; 0.463) to 0.264 (0.203; 0.329) cu (p<0.001) and the absence of changes AASI value in women of the control group – 0.360 (0.283; 0.471) and 0.370 (0.310; 0.476) cu. In women of the main group, an increase in the brachial artery EDV was found from 8.6±7.4% initially to 11.1±6.8% by the end of the study (p<0.05) and no change in women in the control group −7.3±5.6% and 6.2±5.0%. Conclusion In women in early postmenopause with prolonged MHT of 1 mg E2/2 mg DRSP positive changes in the structural and functional state of the vascular wall were established.

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