CHEMICAL, SEROLOGICAL AND BIOLOGICAL PROPERTIES OF A SEROTYPE-SPECIFIC POLYSACCHARIDE ANTIGEN IN LEPTOSPIRA

1974 ◽  
Vol 52 (2) ◽  
pp. 311-319 ◽  
Author(s):  
S Faine ◽  
B Adler ◽  
A Palit
Keyword(s):  
Biological Properties ◽  
Polysaccharide Antigen ◽  
Specific Polysaccharide

Structure and Biological Properties of the O-specific Polysaccharide and Lipid a from Pantoea agglomerans P324

Microbiology ◽  
2021 ◽  
Vol 90 (1) ◽  
pp. 96-105
Author(s):  
E. L. Zdorovenko ◽  
A. A. Kadykova ◽  
A. S. Shashkov ◽  
L. D. Varbanets ◽  
T. V. Bulyhina ◽  
...  
Keyword(s):  
Lipid A ◽  
Biological Properties ◽  
Pantoea Agglomerans ◽  
Specific Polysaccharide

Attenuation of Glucan-binding Protein C Reduces the Cariogenicity of Streptococcus mutans: Analysis of Strains Isolated from Human Blood

2002 ◽  
Vol 81 (6) ◽  
pp. 376-379 ◽  
Author(s):  
K. Nakano ◽  
M. Matsumura ◽  
M. Kawaguchi ◽  
T. Fujiwara ◽  
S. Sobue ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Protein C ◽  
Southern Hybridization ◽  
Cellular Adhesion ◽  
Binding Activity ◽  
Sequencing Analysis ◽  
Polysaccharide Antigen ◽  
Blood Isolate ◽  
Cell Surface Structures ◽  
Specific Polysaccharide

A blood isolate of Streptococcus mutans strain TW871 shows relatively low homology with MT8148, a reference oral isolate strain, and lacks the serotype-specific polysaccharide antigen, suggesting that other cell-surface structures correlate with cariogenicity. We compared cariogenicity of TW871 with MT8148 (serotype c) and blood isolate TW964 (serotype f) in rats. Strain TW871 showed significantly lower cariogenicity than MT8148 or TW964 and expressed significantly lower sucrose-independent cellular adhesion to saliva-coated hydroxyapatite and dextran-binding activity than strain MT8148. Strains TW871 and TW964 showed a defect in the gbpA gene by Southern hybridization analysis, while sequencing analysis revealed gbpC variation in TW871. These results suggest that variation in GbpC may alter cellular adherence properties and can be correlated with the cariogenicity of S. mutans in this strain.

scholarly journals THE EFFECT OF THE BACTERIOLYTIC ENZYME OF PNEUMOCOCCUS UPON THE ANTIGENICITY OF ENCAPSULATED PNEUMOCOCCI

1937 ◽  
Vol 66 (1) ◽  
pp. 113-123 ◽  
Author(s):  
René J. Dubos
Keyword(s):  
Capsular Polysaccharide ◽  
Specific Resistance ◽  
Bacterial Species ◽  
Antigenic Property ◽  
Type I ◽  
Subsequent Infection ◽  
Polysaccharide Antigen ◽  
Bacteriolytic Enzyme ◽  
Active Immunity ◽  
Specific Polysaccharide

1. Mice immunized with heat-killed cells of virulent pneumococci (Type I) which have been treated with active preparations of the bacteriolytic enzyme, develop a certain degree of type specific resistance to subsequent infection. This active immunity, however, appears to be due to the small amount of free acetyl polysaccharide present in the suspension of digested bacteria, and is always of a less pronounced degree than that obtained with intact heat-killed cells. 2. Virulent pneumococci killed by heat or iodine when subjected to the action of active preparations of the bacteriolytic enzyme lose the antigenic property of stimulating in rabbits the formation of precipitating antibodies for the type specific polysaccharide. 3. The enzyme prepared from S or R pneumococci, irrespective of type derivation, is equally effective against the capsular polysaccharide antigen of any specific type of this bacterial species. 4. The inactivation of the capsular polysaccharide antigen is observed when the cells are merely rendered Gram-negative, without being caused to undergo actual disintegration or lysis. 5. These observations emphasize the importance of minimizing the chances of alterations due to the action of cellular enzymes in the course of preparation of the cell suspension to be used as immunizing agents.

Structure of the type-specific polysaccharide antigen of Streptococcus rattus

1991 ◽  
Vol 210 ◽  
pp. 247-254 ◽  
Author(s):  
David G. Pritchard ◽  
Brenda P. Rener ◽  
N.Rama Krishna ◽  
Dee-Hua Huang
Keyword(s):  
Polysaccharide Antigen ◽  
Specific Polysaccharide ◽  
Streptococcus Rattus

scholarly journals THE EFFECT OF A TISSUE ENZYME UPON PNEUMOCOCCI

1938 ◽  
Vol 67 (5) ◽  
pp. 791-797 ◽  
Author(s):  
René J. Dubos ◽  
C. M. MacLeod
Keyword(s):  
Nucleic Acid ◽  
Capsular Polysaccharide ◽  
Polymorphonuclear Leucocytes ◽  
Bacterial Cells ◽  
Animal Tissues ◽  
Polysaccharide Antigen ◽  
Encapsulated Cells ◽  
Specific Polysaccharide ◽  
Intradermal Route

Polymorphonuclear leucocytes contain an enzyme which destroys the basophilic character of beat-killed pneumococci (R and S variants) and inactivates the type specific polysaccharide antigen of encapsulated cells. The same enzyme, however, fails to cause a disintegration of the bacterial cells, or to decompose the capsular polysaccharide itself. The enzyme has been extracted from a number of animal tissues; it appears identical with a purified enzyme extracted from pancreatin and which decomposes yeast nucleic acid. These facts are considered with regard to the failure of rabbits to produce the type specific carbohydrate antibodies when immunized with heat-killed encapsulated pneumococci by the intradermal route.

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