LONG TERM EFFECTS OF VASECTOMY ON EXPERIMENTAL ATHEROSCLEROSIS IN RHESUS MONKEYS

8 isolate monkeys were compared in a follow-up study to 8 sophisticated controls in brief cross-sectional pairings with 12 stimulus strangers: 4 adults, 4 age-mates, and 4 juveniles. The isolates were characterized by infantile disturbance, less environmental orality, more fear, more aggression, less sex, less play, and bizarre ritualistic movements. 12-mo. isolates were fearful and nonaggressive but threatened many attacks. 6-mo. isolates were fearful and physically aggressive. The 12-mo. isolates demonstrated practically no positive social behavior. Conclusions are: (a) 6 mo. of social isolation during the first year has negative effects on social behavior up to puberty, (b) abnormal aggression appears in 3-yr.-old 6-mo. isolates, and (c) 12 mo. of isolation suppress or delay this aggression.

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Long-term effects of simulated sonic booms on hearing in rhesus monkeys

Journal of Sound and Vibration ◽

10.1016/s0022-460x(87)80221-3 ◽

1987 ◽

Vol 113 (2) ◽

pp. 355-363 ◽

Cited By ~ 4

Author(s):

S. Reinis ◽

D.S. Weiss ◽

J.W. Featherstone ◽

C. Tsaros

Keyword(s):

Rhesus Monkeys ◽

Long Term Effects ◽

Sonic Booms

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Long-term effects of total-body irradiation on the kidney of Rhesus monkeys

International Journal of Radiation Biology ◽

10.1080/095530000138303 ◽

2000 ◽

Vol 76 (5) ◽

pp. 641-648 ◽

Cited By ~ 20

Author(s):

E. M. van Kleef, C. Zurcher, Y. G. Ous

Keyword(s):

Total Body Irradiation ◽

Rhesus Monkeys ◽

Long Term Effects ◽

Total Body

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Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the corticotropin-releasing hormone challenge during the first 3 years of life in group-living rhesus monkeys

Development and Psychopathology ◽

10.1017/s0954579409990253 ◽

2010 ◽

Vol 22 (1) ◽

pp. 45-53 ◽

Cited By ~ 66

Author(s):

Mar M. Sanchez ◽

Kai Mccormack ◽

Alison P. Grand ◽

Richelle Fulks ◽

Anne Graff ◽

...

Keyword(s):

Sex Differences ◽

Hpa Axis ◽

Rhesus Monkeys ◽

Group Living ◽

Cortisol Response ◽

Corticotropin Releasing Hormone ◽

Long Term Effects ◽

Releasing Hormone ◽

Cortisol Responses

AbstractIn this study we investigated the development of the hypothalamic–pituitary–adrenal (HPA) axis in 21 group-living rhesus monkeys infants that were physically abused by their mothers in the first few months of life and in 21 nonabused controls. Cortisol and adrenocorticotropin hormone (ACTH) responses to a corticotropin-releasing hormone (CRH) challenge were assessed at 6-month intervals during the subjects' first 3 years of life. Abused infants exhibited greater cortisol responses to CRH than controls across the 3 years. Abused infants also exhibited blunted ACTH secretion in response to CRH, especially at 6 months of age. Although there were no significant sex differences in abuse experienced early in life, females showed a greater cortisol response to CRH than males at all ages. There were no significant sex differences in the ACTH response to CRH, or significant interactions between sex and abuse in the ACTH or cortisol response. Our findings suggest that early parental maltreatment results in greater adrenocortical, and possibly also pituitary, responsiveness to challenges later in life. These long-term alterations in neuroendocrine function may be one the mechanisms through which infant abuse results in later psychopathologies. Our study also suggests that there are developmental sex differences in adrenal function that occur irrespective of early stressful experience. The results of this study can enhance our understanding of the long-term effects of child maltreatment as well as our knowledge of the development of the HPA axis in human and nonhuman primates.

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