Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited
2009 ◽
Vol 30
(1)
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pp. 46-50
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Keyword(s):
Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution ( VT) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bound radioligand ( VND) is also required to distinguish specific from total binding. However, a true reference region, devoid of specific binding, is often not available. We present a transformation of a graphical method, originally introduced by Lassen, using regional estimates of VT alone to determine occupancy, together with an extension that does not require baseline data.
2011 ◽
Vol 32
(1)
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pp. 70-80
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2011 ◽
Vol 31
(8)
◽
pp. 1807-1816
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2019 ◽
Vol 40
(9)
◽
pp. 1890-1901
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Keyword(s):
2014 ◽
Vol 34
(7)
◽
pp. 1162-1168
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2015 ◽
Vol 35
(5)
◽
pp. 743-746
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2019 ◽
Vol 40
(4)
◽
pp. 860-874
1998 ◽
Vol 18
(10)
◽
pp. 1130-1142
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