scholarly journals Iron and Early Brain Injury after Subarachnoid Hemorrhage

2010 ◽  
Vol 30 (11) ◽  
pp. 1791-1792 ◽  
Author(s):  
Matthew C Loftspring
Keyword(s):  
Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Oxidative Dna Damage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Iron Chelation ◽  
Early Brain Injury ◽  
Delayed Cerebral Vasospasm ◽  
Insight Into

Aneurysmal subarachnoid hemorrhage (SAH) affects approximately 27,000 Americans per year. Although delayed cerebral vasospasm is of high clinical significance, mortality within the first 2 days may approach 30%. In this issue of the Journal of Cerebral Blood Flow and Metabolism, Lee et al have studied the role of iron in early brain injury after experimental SAH. They found that iron chelation with deferoxamine reduced mortality and oxidative DNA damage, and lessened the induction of iron-handling proteins. Taken together, these results highlight the deleterious potential of blood breakdown products and provide an insight into future intervention.

Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats

2015 ◽  
Vol 157 (5) ◽  
pp. 781-792 ◽  
Author(s):  
Ji-Yang An ◽  
Li-Li Zhou ◽  
Peng Sun ◽  
Hong-Gang Pang ◽  
Dan-Dong Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Signaling Pathway ◽  
Early Brain Injury ◽  
Ampk Signaling

scholarly journals Non-Ischemic Cerebral Energy Dysfunction at the Early Brain Injury Phase following Aneurysmal Subarachnoid Hemorrhage

2017 ◽  
Vol 8 ◽  
Author(s):  
Laurent Carteron ◽  
Camille Patet ◽  
Daria Solari ◽  
Mahmoud Messerer ◽  
Roy T. Daniel ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Early Brain Injury

scholarly journals Role of Interleukin-1β in Early Brain Injury After Subarachnoid Hemorrhage in Mice

Stroke ◽  
2009 ◽  
Vol 40 (7) ◽  
pp. 2519-2525 ◽  
Author(s):  
Takumi Sozen ◽  
Reiko Tsuchiyama ◽  
Yu Hasegawa ◽  
Hidenori Suzuki ◽  
Vikram Jadhav ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Early Brain Injury ◽  
Interleukin 1Β

scholarly journals The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage

2021 ◽  
Vol 12 ◽  
Author(s):  
Lingxin Cai ◽  
Hanhai Zeng ◽  
Xiaoxiao Tan ◽  
Xinyan Wu ◽  
Cong Qian ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Critical Role ◽  
Delayed Cerebral Ischemia ◽  
Early Brain Injury ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Novel Therapeutic Strategies ◽  
Improved Accuracy

Aneurysmal subarachnoid hemorrhage (aSAH) is an important type of stroke with the highest rates of mortality and disability. Recent evidence indicates that neuroinflammation plays a critical role in both early brain injury and delayed neural deterioration after aSAH, contributing to unfavorable outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a peripheral biomarker that conveys information about the inflammatory burden in terms of both innate and adaptive immunity. This review summarizes relevant studies that associate the NLR with aSAH to evaluate whether the NLR can predict outcomes and serve as an effective biomarker for clinical management. We found that increased NLR is valuable in predicting the clinical outcome of aSAH patients and is related to the risk of complications such as delayed cerebral ischemia (DCI) or rebleeding. Combined with other indicators, the NLR provides improved accuracy for predicting prognosis to stratify patients into different risk categories. The underlying pathophysiology is highlighted to identify new potential targets for neuroprotection and to develop novel therapeutic strategies.

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