scholarly journals Tract-Specific Fractional Anisotropy Predicts Cognitive Outcome in a Community Sample of Middle-Aged Participants with White Matter Lesions

2014 ◽  
Vol 34 (5) ◽  
pp. 861-869 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
White Matter ◽  
Fractional Anisotropy ◽  
Predictive Value ◽  
Diffusion Tensor ◽  
Community Sample ◽  
White Matter Lesions ◽  
Cognitive Outcome ◽  
Cerebral White Matter ◽  
High Grade ◽  
Middle Aged

Cerebral white matter lesions (WMLs) have been consistently related to cognitive dysfunction but the role of white matter (WM) damage in cognitive impairment is not fully determined. Diffusion tensor imaging is a promising tool to explain impaired cognition related to WMLs. We investigated the separate association of high-grade periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) with fractional anisotropy (FA) in middle-aged individuals. We also assessed the predictive value to cognition of FA within specific WM tracts associated with high-grade WMLs. One hundred participants from the Barcelona-AsIA Neuropsychology Study were divided into groups based on low- and high-grade WMLs. Voxel-by-voxel FA were compared between groups, with separate analyses for high-grade PVHs and DWMHs. The mean FA within areas showing differences between groups was extracted in each tract for linear regression analyses. Participants with high-grade PVHs and participants with high-grade DWMHs showed lower FA in different areas of specific tracts. Areas showing decreased FA in high-grade DWMHs predicted lower cognition, whereas areas with decreased FA in high-grade PVHs did not. The predictive value to cognition of specific WM tracts supports the involvement of cortico-subcortical circuits in cognitive deficits only in DWMHs.

Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

2012 ◽  
Vol 18 (5) ◽  
pp. 874-885 ◽  
Author(s):  
Juan José Soriano-Raya ◽  
Júlia Miralbell ◽  
Elena López-Cancio ◽  
Núria Bargalló ◽  
Juan Francisco Arenillas ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Executive Functioning ◽  
Verbal Fluency ◽  
Community Sample ◽  
White Matter Lesions ◽  
High Grade ◽  
Psychomotor Speed ◽  
Middle Aged ◽  
Visuospatial Skills

AbstractThe association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)

P1.008 Diffusion tensor imaging and hypertension in elderly with cerebral white matter lesions. The RUN DMC study

2008 ◽  
Vol 14 ◽  
pp. S12-S13
Author(s):  
R.A.R. Gons ◽  
K.F. De Laat ◽  
A.G.W. Van Norden ◽  
L.J.B. Van Oudheusden ◽  
M.P. Zwiers ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

Silent Cerebral White Matter Lesions and Their Relationship With Vascular Risk Factors in Middle-Aged Predialysis Patients With CKD

2006 ◽  
Vol 47 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Alberto Martinez-Vea ◽  
Esther Salvadó ◽  
Alfredo Bardají ◽  
Cristina Gutierrez ◽  
Ana Ramos ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Lesions ◽  
Vascular Risk Factors ◽  
Cerebral White Matter ◽  
Vascular Risk ◽  
Middle Aged ◽  
Cerebral White Matter Lesions

Silent cerebral white matter lesions in middle-aged essential hypertensive patients

2002 ◽  
Vol 20 (3) ◽  
pp. 519-524 ◽  
Author(s):  
Cristina Sierra ◽  
Alejandro de la Sierra ◽  
Josep Mercader ◽  
Elisenda Gómez-Angelats ◽  
Alvaro Urbano-Márquez ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Middle Aged ◽  
Hypertensive Patients ◽  
Cerebral White Matter Lesions

scholarly journals Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Naoki Yamada ◽  
Ryo Ueda ◽  
Wataru Kakuda ◽  
Ryo Momosaki ◽  
Takahiro Kondo ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Transcranial Magnetic Stimulation ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Motor Function ◽  
Magnetic Stimulation ◽  
Diffusion Tensor ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Cerebral White Matter ◽  
Imaging Evaluation

We aimed to investigate plastic changes in cerebral white matter structures using diffusion tensor imaging following a 15-day stroke rehabilitation program. We compared the detection of cerebral plasticity between generalized fractional anisotropy (GFA), a novel tool for investigating white matter structures, and fractional anisotropy (FA). Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) of 2400 pulses applied to the nonlesional hemisphere and 240 min intensive occupation therapy (OT) daily over 15 days. Motor function was evaluated using the Fugl-Meyer assessment (FMA) and Wolf Motor Function Test (WMFT). Patients underwent diffusion tensor magnetic resonance imaging (MRI) on admission and discharge, from which bilateral FA and GFA values in Brodmann area (BA) 4 and BA6 were calculated. Motor function improved following treatment (p<0.001). Treatment increased GFA values for both the lesioned and nonlesioned BA4 (p<0.05, p<0.001, resp.). Changes in GFA value for BA4 of the lesioned hemisphere were significantly inversely correlated with changes in WMFT scores (R2=0.363, p<0.05). Our findings indicate that the GFA may have a potentially more useful ability than FA to detect changes in white matter structures in areas of fiber intersection for any such future investigations.

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